Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"condensin II"”.
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Analyse von Condensin-Komplexen in Drosophila melanogaster Charakterisierung der Untereinheit CapG und Identifizierung von Interaktionen
… Stabilität der Zellen. Der heteropentamere Condensin-Komplex ist hierbei an der Strukturierung der Chromosomen und deren physikalischer Stabilität während der Segregation maßgeblich beteiligt. In höheren Eukaryoten konnten zwei dieser Komplexe (Condensin I und Condensin II) identifiziert …
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Functional investigation of the role of the retinoblastoma protein in genome stability
… also investigates the functions of the pRB-condensin II complex in maintaining genome stability, specifically in interphase cells. Using a gene-targeted mouse model that disrupts the ability of pRB to recruit condensin II, Rb1L, locations of pRB-dependent condensin II recruitment were …
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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
… genome stability suggests that a pRB-E2F1-Condensin II complex localizes to pericentromeric heterochromatin. In the absence of this complex, DNA double strand breaks are observed and persist into mitosis and the ensuing G1 phase of the cell division cycle. Moreover, haploinsufficiency of …
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Genome organization by loop extrusion
… by loop extrusion. We also find that cohesin and condensin, two deeply conserved SMC complexes, play strikingly different roles in the yeast mitosis. While cohesin is responsible for compacting the bulk of chromosome arms, condensin has a more targeted role compacting the rDNA proximal regions and …