Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"computational validation"”.
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Development of novel lysine targeting covalent inhibitors for Bruton’s tyrosine kinase and casein kinase 2 and synthesis of novel hybrid androgen receptor inhibitors
… hybrid AR inhibitor. 2) We report the design, computational validation and synthesis of a proposed lysine targeting allosteric CK2 inhibitor. The challenging synthetic steps towards the peptidomimetic electrophile are presented, along with the biological characterisation of the final target …
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Skin Friction and Cross-flow Separation on an Ellipsoidal Body During Constant Yaw Turns and a Pitch-up Maneuver with Roll Oscillation
… in the world and serves as a crucial tool for computational validation. The ellipsoidal model was mounted on a roll oscillation machine in the Virginia Tech Stability Wind Tunnel slotted wall test section. Hot-film sensors with constant temperature anemometers provided skin friction magnitudes …
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Caging and Transport in Simple Disordered Systems
… scalings should persist in the limit d→∞. The computational validation evaluates directly the dynamical critical exponents below d_u as well as their logarithmic scaling above d_u. Our numerical results improve various earlier estimates and are fully consistent with our theoretical …
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Experimental and Numerical Explorations of Fire Performance of Intumescent Thermoplastic Composites for Electric Vehicle Battery Enclosures
… candidate selected as a benchmark for computational validation. The key characterizations of the intumescent, decomposing thermoplastic systems are thickness expansion and viscoelasticity. The evolution of thickness expansion and softening behavior across the full thermal spectrum and …
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Design and investigation of a novel 𝝿-configuration spr sensor for multi-parameter biosensing applications.
… foundational contribution is the conception and computational validation of this unique geometric architecture, which features two independent, adjacent sensing arms on a single optical fibre. Through comprehensive three-dimensional Finite Element Method (FEM) simulations in COMSOL Multiphysics, …
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Fluid Flow Characterization and In Silico Validation in a Rapid Prototyped Abdominal Aortic Aneurysm Model
… of the AAA, and use this construct to validate a computational model of the same aneurysm through flow visualization. The hypothesis was that the fluid velocities within the physical construct would accurately mimic the fluid velocities used in the computational model. The physical model was …
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A study on the flow characteristics of an industrial radiant tube burner
… To achieve this, a detailed three-dimensional Computational Fluid Dynamics (CFD) model has been used, validated with experimental air flow, temperature and flue gas measurements. Initially, the work programme is presented and the theory behind RTB design and operation in addition to the theory …