Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"complexity region"”.
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Structural Studies of Two Related Metallohydrolases: Human Histone Deacetylase 8 and Malarial Arginase
… enzyme from Plasmodium falciparum contains a low complexity region insert of ~75 residues within the L2-loop, confirming this protein region to be highly evolvable in proteins which adopt the arginase fold. Kinetics analyses indicate this insertion to be nonessential for catalytic activity. An …
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Characterization and Modulation of the Emergent Material Properties of Biomolecular Condensates
… Previous studies suggest that the low complexity region (LCR) of FMRP has a preferential binding affinity towards G-quadruplex - containing mRNA. We find that these RNAs can modulate the material properties of FMRP-LCR liquid droplets as a function of secondary structure and binding …
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Investigating the role of ICL3 in β1-adrenergic receptor activation
… needed to study the dynamic nature of this low complexity region in these receptors. In this thesis, I have investigated β1AR conformational dynamics by creating a chimera of tβ1AR transmembrane domain with the flexible ICL3 from human β1AR (hICL3). The position of ICL3 is close to the G protein …
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Overcoming Computational Complexity Barriers for Optimal Transport in Discrete and Semi-Discrete Settings
… that outputs the mass of $mu$ inside a constant-complexity region in $O(1)$ time. In this thesis, given a parameter $varepsilon>0$, we present the following results for the semi-discrete OT problem between $mu$ and $nu$: 1. Additive approximation for semi-discrete OT: We present an …