Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 51 for “"complex trait"”.
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Medaka fish as a model for complex trait genetics
… — to investigate the genetic architecture of complex traits, with a particular focus on non-additive genetic effects. My research addresses two phenotypes: one physiological (heart rate) and one behavioural (bold-shy behaviour). After providing an overview of the history of genetics and the …
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Fine mapping studies of quantitative trait loci for baseline platelet count in mice and humans
Platelet count is a complex trait with a substantial genetic contribution. Platelets have a fundamental role in normal haemostasis, with both increases and decreases of the platelet count associated with significant mortality and morbidity. Despite the significant genetic component contributing to …
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Physiological Bases and a Novel Genetic Determinant of Water-Use Efficiency (WUE)
… of biomass to water loss, is a heritable but complex trait, the genetic basis of which is largely unknown. We utilized diverse accessions of the halophyte <em>Eutrema salsugineum </em>to ultimately identify a novel genetic determinant of WUE. <em>E. salsugineum</em> accessions from locations …
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Flavour quality factors and its regulation in red raspberry (rubus idaeus)
… possible causal relationships. These flavour traits data were then mapped to genetic loci and / or candidate genes on an already existing raspberry genetic linkage map and generated genomic regions most likely responsible for trait variation, potentially genetic markers for flavour quality. …
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Patterns of linkage disequilibrium in the human genome
… in the field of human genetics, the cloning of complex trait mutations remains a challenging and unresolved process. This continuing difficulty is responsible for an ever-increasing awareness of the phenomenon of linkage disequilibrium (LD). The principle behind LD is relatively simple. Over the …
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Investigating adipose tissue angiogenesis in obesity reveals a novel role for thrombospondin-1.
… has proven extremely challenging. Obesity is a complex trait involving the interaction of genes involved in fundamental aspects of weight maintenance, exposure to an environment characterised by an over-abundance of food and sedentary life-style choices with limited physical activity (Poskitt …
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Taste physiological mechanisms and their health implications, analyzed by genetic, epigenetic, and artificial intelligence analyses
Taste perception is a complex trait influenced by genetic, epigenetic, physiological, and pathological factors, with significant implications for nutrition, health, and disease. Our studies integrated molecular biology, psychophysics, and advanced machine learning methods to explore …
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Generalization of kernel machine methods for association testing of multi-omics data
… identified thousands of loci associated with complex traits and diseases in humans. Despite the immense success of these statistical tools, post-GWAS, we are often left underwhelmed by findings that are difficult to interpret or fail to to lead to causal mechanisms and deeper understanding of …
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Semantic and pragmatic language development in typical acquisition, autism spectrum disorders, and Williams syndrome with reference to developmental neurogenetics of the latter
The elucidation of the biological bases of a complex trait like human language proceeds from identification of precise behavioral phenotypes to investigation of the underlying genes. The human behavioral parts of this dissertation focus on understanding the reasons for children's overuse of …
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When the Map Fails the Territory: Hidden State Models, Complex Traits and the Evolution of Bird Migration
… comparative methods often rely on simplifying complex biological traits into discrete categories, potentially obscuring evolutionary patterns and generally limiting inferences. This dissertation confronts this ``map versus territory" problem by developing and evaluating methodological …
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GENETIC DISSECTION OF MATURITY DATE IN PEACH AND APRICOT REVEAL A ROLE FOR CONSERVED GENE NETWORKS
… transfer from peach. Maturity Date (MD) is a complex trait, influenced by multiple factors, both environmental and genetical, being of notewhorthy importance and impact in the orchard management activities. Nevertheless MD is characterized by a high variability, having cultivated varieties …
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Phenomics enabled genetic dissection of complex traits in wheat breeding
… from genotypes is a difficult problem due to the complex nature of genomes, the environment, and their interactions. While the recent advancements in genome sequencing technologies have provided almost unlimited access to high-density genetic markers, large-scale rapid and accurate phenotyping of …
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Characterisation of Rare Genetic Variants Conferring Susceptibility to Psoriasis
… skin disorder that is inherited as a complex trait. Although genome-wide association studies (GWAS) have identified a number of common disease susceptibility alleles, a substantial fraction of psoriasis heritability remains unexplained, suggesting the possibility that rare variants may …
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A molecular genetic analysis of Crohn’s disease susceptibility loci in psoriasis
… skin disorder that is inherited as a complex trait. Genome-wide linkage and association studies have identified a major disease susceptibility locus (PSORS1) and several genetic determinants of smaller effect. At least two of these (the IL12B and IL23R genes) have independently been …
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Genetics of Experience: Genetically Sensitive Approaches to Measuring Childhood Environment
… data confirmed that victimization is a typical complex trait with a common genetic liability.<br/>The approach taken here was to explore gene-environment mechanisms at the interface between nature and nurture using a variety of childhood experiences rather than focusing on one particular …
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Evaluation of Genomic Prediction and the Agronomic Performance of Facultative Barley
… suggesting that facultative habit is a more complex trait than previously understood. Significant epistatic interactions between chromosome 4H and 4 other chromosomes were discovered. These findings indicate facultative habit is a much more quantitative trait than previously reported. The …
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Improving Clinical Risk Models through Integration of Polygenic Risk Scores and Omics
… by leveraging thousands of loci associated with complex traits and diseases, leading to breakthroughs in human genetics research. However, interpretation of these results is often difficult as the GWAS-identified variants (single-nucleotide polymorphisms [SNPs]) often have small effect estimates …
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The genetic determinants of vigour control and precocity by pear (Pyrus communis L.) rootstocks
… are therefore two of the most important traits in commercial pear production. Dwarfing rootstocks are used to reduce the size of the scion and enable precocious flowering in many perennial cultivars. Currently there is a lack of Pyrus rootstocks that are vigour-controlling and …
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Genomic and Physiological Approaches to Improve Drought Tolerance in Soybean
… drought tolerance through the identification of traits associated with drought tolerance that can be used as indirect selection criteria in a breeding program. Carbon isotope ratio (δ13C, associated with water use efficiency), oxygen isotope ratio (δ18O, associated with transpiration), canopy …
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