Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"complex molecule synthesis"”.
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Selective C—H oxidations for complex molecule synthesis and diversification
… more efficient and selective methods for the synthesis of both simple and complex molecules. Traditionally, starting materials for synthesis are derived from petroleum or other natural sources and have been pre-oxidized and pre-activated with reactive functional groups. These functional groups …
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C—H oxidation reactions in complex molecule synthesis: application and development
… efficiency and diversity in the construction of complex molecules. Oxidation reactions of C–H bonds, particularly when applied at late-stages of complex molecule syntheses, hold special promise for achieving both these goals by minimizing the use of functional group manipulations typically …
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Development of three-component alkene and 1,3-diene carbofunctionalization reactions
Given the prevalence of nitrogen-containing molecules in pharmaceuticals and agrochemicals, the development of efficient amination reactions is an essential research effort within the broad confines of organic method development. The ever-increasing complexity of the molecular structures used to …
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Development and investigation of novel chemoselective processes in Pd and Cu catalysis
… described as 'the single greatest obstacle to complex molecule synthesis'. Chemoselectivity is required to exploit the full potential of synthetic developments in organic chemistry, allowing for more efficient procedures and better route design. This thesis will describe the development of …
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C—H oxidation reactions: development and application
… are emerging as a powerful new approach for complex molecule synthesis. The development of reactions that are selective, catalytic, mild, and efficient have the potential to significantly streamline the synthesis of organic molecules used in medicine, biological studies, materials chemistry, …
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Chemical approaches to understanding small-molecule accumulation in bacteria and poly(ADP-ribosyl)ation
… bacterial cells. A combined effort featuring complex molecule synthesis, microbiology, and cheminformatics has led to the development of guidelines that enable compound entry. These guidelines can jump-start stalled antibiotic projects and help usher new classes of drugs into the clinic. …
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Discovery of covalent modifiers via the complexity to diversity strategy
… molecular weight compounds that are lacking in complexity and are incapable of addressing more complex targets, such as protein-protein interactions. To fill this gap, a library of 19 complex and diverse compounds containing electrophilic moieties has been synthesized and screened for anticancer …