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Showing 1 to 4 of 4 for “"complex integrity"”.
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The Regulation of Mtorc2 Kinase Activity and Complex Integrity
… the</p> <p>mammalian Target of Rapamycin Complex 2 (mTORC2) was identified as the</p> <p>main Akt Ser-473 kinase, and Ser-473 phosphorylation is required for Akt</p> <p>hyperactivation. However, the detailed mechanism of mTORC2 regulation in</p> <p>response to growth factor stimulation or …
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The Role of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis
… this phosphorylation is essential for Skp2 SCF complex integrity and E3 ligase activity to ubiquitinate Akt, which is critical for Akt activation. Also, Skp2 S256 phosphorylation can be induced by many stress and EGF. The phosphorylation status is necessary for breast cancer tumor progression …
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Novel Posttranslational Modification In Lkb1 Activation and Function
… under energy stress. LKB1 forms a heterotrimeric complex and is activated through binding of the two regulatory proteins, STRAD and MO25. LKB1 has been shown to be a tumor-suppressor in various mouse models; however, recent studies suggest that LKB1 has pro-oncogenic functions. How the LKB1 …
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE ISW2 CHROMATIN REMODELING COMPLEX
… with accessory Itc1 subunit to maintain ISW2 complex integrity. The two ways by which SLIDE domain regulate ISW2 is by binding or recruitment of ISW2 to promoter regions and additionally by binding independent regulation of both ATPase and remodeling activity. The remodeling mechanism of ISW2 …