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Showing 1 to 20 of 54 for “"complex assembly"”.
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Quality control of protein complex assembly
All cells contain numerous multi-subunit protein complexes of exceptional abundance and physiological importance. Prominent examples include the ribosome, proteasome, chaperonin, tubulin, haemoglobin, and many others. A major challenge for the cell is to synthesise individual subunits in the …
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Preinitiation Complex Assembly and General Transcription Factor IIA
… assay. Using this assay, a partial preinitiation complex containing TFIIB is implicated as a target of GaI4-IE. These experiments, as well as others cited, suggest that activators affect early stages of PIC assembly, namely the formation of complexes including TFIID, TFIIA, and TFIIB. To further …
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Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores
… kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC), activates the mitotic checkpoint complex (MCC), to inhibit the E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C). Inhibition of the APC/C then delays premature chromosome segregation by preventing …
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An applied manufacturing system for highly-complex assembly factory
… demand for its products that require highly-complex assembly within the factory. When the demand is low, the manufacturing factory must to adjust the production performance, and implement various cost reductions in order to maintain profit. Hence, the major motivation of this thesis is to …
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The Acquisition of a Complex Assembly Task by Retarded Adolescents
Made available in DSpace on 2014-12-08T21:25:36Z (GMT). No. of bitstreams: 1 7000857.pdf: 1148029 bytes, checksum: 8db8b27437c0d8de822c0f01b3841e13 (MD5) Previous issue date: 1969
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Tap /Nxf1 N -Terminal Domain Mediates Homotypic Complex Assembly and Is Necessary for Nuclear RNA Export
… with nucleoporin proteins of Nuclear Pore Complexes (NPCs) as well as messenger RNA cargo. It has been long understood that the NXF family is unique from the Karyopherin transport receptor family and that RNA export functions independently of the nuclear Ran-GTP gradient. Until now the …
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A nanobody suite for yeast scaffold nucleoporins provides details of the Y complex structure and nuclear pore complex assembly
Nuclear pore complexes (NPCs) are the main conduits for molecular exchange across the nuclear envelope. The NPC is a modular assembly of ~500 individual proteins, called nucleoporins or nups, that can be classified into three categories: 1. Stably associated scaffolding nups, 2. Peripheral nups, …
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Enabling New Functionally Embedded Mechanical Systems Via Cutting, Folding, and 3D Printing
… in relatively high design iteration times and complex assembly strategies.
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Enzymatic and Splicing Activity of Class I Leucyl -Trna Synthetases From Escherichia Coli and Saccharomyces Cerevisiae
… assay has been established that is based on assembly of proteins into a competent ternary splicing complex. RNA deletion mutants have been quantitated for effects on complex assembly and splicing activity.
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The Fourier convolution-deconvolution method: its limitation and application
… the conformation of this region during SNARE complex assembly. A 12 -14 Angstrom distance measurement suggests this region to alpha helical, with a small unstructured area, during complex formation. In addition the limits of distance measurements were tested using the continuous wave electron …
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Attribute process methodology : feasibility assessment of Digital Fabrication Production Systems for planar part assemblies using network analysis and System Dynamics
… independently of location. A DFPS project is a complex assembly of custom parts that is delivered by a network of fabrication and assembly processes. This network is called the value chain. Evaluating feasibility of a DFPS project has two main problems: first, how to evaluate assemblability of …
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Unraveling the Role of SNARE Interactions in Neurotransmitter Release
… collectively known as SNAREs and form a tight complex (the core complex). The assembly of the core complex may mediate membrane fusion. Complexin is a highly conserved cytoplasmic protein that binds tightly to the SNARE complex. Analysis of the interaction between complexin and the SNARE …
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Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation
… through Toll-like receptors (TLR) disrupts the assembly of mitochondrial electron transfer chain (ETC) complexes I-V, leading to the metabolic switch by inhibiting OxPhos and activating HIF-1[alpha]-dependent glycolysis. Disassembly of ETC complexes influences the global metabolic status of …
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From Protein Structure to Clinical Strategy: An In silico Investigation of Mitochondrial DNA Mutations in Type 2 Diabetes and Degenerative Disc Disease for Targeted Nutritional Interventions
… the impact of variants on respiratory chain complex assembly and interface stability. Across mitochondrial respiratory complexes I, III, IV, and V, pathogenic variants predominantly produced localized conformational strain and subunit misalignment, reflected by increased root mean square …
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Optimization of Electrode Configurations for Calibration-Free, Remote Sensing of Heavy Metals in Water Using Double-Potenital Step Anodic Coulometry
… but the cost, electrode fabrication, and complex assembly requirements limit commercial viability and motivate this work. We are targeting electrodes that can be inkjet printed directly onto a 3D-printed polymer electrochemical cell, simplifying the manufacturing processes and …
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System variation analysis of MIG welded aluminum structural frames
… approach is explored with an example of a complex assembly of aluminum extrusions and castings welded into a structural frame. By making use of modeling techniques such as Finite Element Analysis (FEA) and Design of Experiments (DOE), it can be shown how this method can also be applied to …
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MECHANISMS OF CHROMATIN REMODELING BY ISWI FAMILY OF REMODELERS: A FUNCTIONAL AND STRUCTURAL INSIGHT INTO THE ROLE OF THE Itc1 SUBUNIT OF ISW2 REMODELING COMPLEX
… nucleosomes. These ATP-dependent remodeling complexes have a relatively small number of subunits (2-4) as compared to other classes of remodelers such as SWI/SNF, RSC and INO80/SWR-C. The accessory subunits of some of the ISWI remodelers from yeast have been shown to contact extensively …
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Put it together : animating machine assembly instructions for novices
… the essence of machine making now lies in part assembly. With the advancement of online education, how will schools teach part assembly? How will Makers share the knowledge of putting things together? Traditional assembly instructions designed with text, diagrams and images are often not …
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NEW STRUCTURAL PERSPECTIVES ON THE BACTERIAL INITIATION COMPLEX
… during the formation of the bacterial Initiation Complex and the proper positioning of the initiator tRNA on the start codon of the mRNA. Nevertheless, the limited resolution of the structures hampered gaining a pristine view of the molecular details that are essential for the correct assembly of …
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Self-assembly of filopodia-like structures on supported lipid bilayers
… as sensory organelles. To probe their pathway of assembly we have reconstituted filopodia-like structures (FLSs) by applying frog egg extracts to supported lipid bilayers containing phosphatidylinositol(4,5)bisphosphate, PI(4,5)P 2. The FLSs recapitulate important characteristics of filopodia - …
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