Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 178 for “"complex I"”.
-
New gene defects for human complex I deficiency.
Contains fulltext : 90832.pdf (Publisher’s version ) (Open Access)
-
Disease biology of mitochondrial complex-I: Proteomics insights
Contains fulltext : 110935.pdf (Publisher’s version ) (Open Access)
-
Cryo-electron microscopy studies on ovine mitochondrial complex I
… the atomic structure of mammalian respiratory complex I. Mitochondrial complex I (also known as NADH:ubiquinone oxidoreductase) is one of the central enzymes in the oxidative phosphorylation pathway. It couples electron transfer between NADH and ubiquinone to proton translocation across the …
-
Investigating the Role of Complex I Loss in Thyroid Tumorigenesis
… (TCV-PTC) tumors demonstrate widespread loss of Complex I of the electron transport chain. TCV-PTC is a clinically aggressive form of papillary thyroid cancer, driven universally by the BRAF V600E activating mutation. I have developed a murine model of Braf-driven thyroid cancer to investigate …
-
Structural and functional studies of mitochondrial NADH:ubiquinone oxidoreductase (complex I)
NADH:ubiquinone oxidoreductase (complex I) is the largest and most complicated enzyme in the mitochondrial electron transfer chain. It catalyses the oxidation of NADH and the reduction of ubiquinone, coupled to the translocation of protons across the mitochondrial inner membrane, maintaining the …
-
Pharmacological aspects of the inhibition of mammalian respiratory complex I
Mitochondrial complex I, a large respiratory enzyme located in the inner mitochondrial membrane, catalyses electron transfer from NADH to ubiquinone while concomitantly translocating protons across the membrane to sustain ATP synthesis. A crucial aspect of the pharmacology of complex I is …
-
Investigating the rate-limiting step of mitochondrial complex I catalysis
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a key enzyme in metabolism and is the least understood protein in the mitochondrial electron transfer chain (ETC). It couples the energy released from NADH oxidation and ubiquinone (Q) reduction to the translocation of four protons across …
-
Using molecular approaches to understand Complex I deficiency in mouse models
Complex I (NADH:ubiquinone oxidoreductase), a major electron entry point to the mitochondrial respiratory chain, couples electron transfer from NADH to ubiquinone to proton pumping across the mitochondrial inner membrane, and generates the proton motive force that drives ATP synthesis and transport …
-
Studies on assembly and genetic variation in mitochondrial respiratory complex I
Complex I (NADH:ubiquinone oxidoreductase) couples electron transfer to proton translocation across the inner mitochondrial membrane, to drive the synthesis of ATP. Its distinctive L-shaped structure comprises 45 subunits, encoded by both the mitochondrial and nuclear genomes, which are assembled …
-
Investigating complex I dynamics and ROS production in ischaemia-reperfusion injury
… oxygen species (ROS) when oxygen is resupplied. Complex I is a major source of ROS in IR injury, but also in physiological ROS signalling. The enzyme can produce ROS via reverse electron transfer (RET), which is driven by a large protonmotive force (∆p) in conjunction with a reduced coenzyme Q …
-
Investigations of the mechanism of mitochondrial complex I by electron cryomicroscopy
… chain (ETC). The first enzyme in the ETC is complex I (NADH:ubiquinone oxidoreductase). Complex I oxidises NADH in the matrix, reduces ubiquinone in the inner membrane, and couples the energy released to the translocation of four protons across the inner membrane, generating the proton motive …
-
Novel approaches to treat mitochondrial complex-I mediated defects in disease
Dysfunction within complex I (CI) of the mitochondrial electron transport system has been implicated in a number of disease states ranging from cardiovascular diseases to neuro-ophthalmic indications. Herein, we provide three novel approaches to model and study the impacts of injury on the function …
-
The assembly of mitochondrial Complex I. A product of nuclear-mitochondrial synergy.
Contains fulltext : 30935_asseofmic.pdf (Publisher’s version ) (Open Access)
-
Structural Studies into the Mechanism and Organisation of Mammalian Respiratory Complex I
Respiratory complex I (NADH:ubiquinone oxidoreductase) is the major entry point of electrons into the electron transport chain and couples its redox activity with proton pumping across the inner mitochondrial membrane, thus contributing to the proton motive force which drives ATP synthesis. With …
-
A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
… particularly the function of respiratory complex I, has emerged as a key determinant of tumor bioenergetics and signaling. This dissertation investigates how partial complex I dysfunction influences CRC tumor growth and whether the impact of this partial disruption depends on the timing of …
-
Mutagenesis investigations into proton transfer pathways and control points in respiratory complex I
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a large multi-subunit membrane protein that uses the energy from electron transfer from NADH to ubiquinone to transport four protons across an energy transducing membrane. The protons contribute to building the proton-motive force that …
-
Cryo-EM studies of substrate and inhibitor binding to mammalian respiratory complex I
Mammalian respiratory complex I (NADH:ubiquinone oxidoreductase) is an intricate multi-subunit, energy-transducing membrane protein that is essential for aerobic energy metabolism and NADH/NAD⁺ homeostasis. It couples the energy released from NADH oxidation and ubiquinone (Q) reduction to pump four …
-
Structure-function studies of respiratory complex I from Paracoccus denitrificans using membrane mimetics
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a crucial metabolic enzyme that couples the free energy released from NADH oxidation and ubiquinone reduction to translocate four protons across energy-transducing membranes, contributing to the proton motive force that powers oxidative …
-
Paracoccus denitrificans as a model system for studying the mechanism of respiratory complex I
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a crucial metabolic enzyme that couples the free energy released from NADH oxidation and ubiquinone reduction to the translocation of four protons across an energy-transducing membrane, contributing to the proton motive force used to …
Page 1 of 9