Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"complement factor H"”.
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Complement Factor H Related Proteins and their Biological Role During Bacterial Infection
… Individuals with rare defects in the terminal complement pathway are susceptible to meningococcal disease but further genetic factors that contribute to disease susceptibility are less well understood. A genome wide association study has linked polymorphisms in the Complement Factor H (CFH) …
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Interaction of Bacillus Anthracis Exosporium Protein Bcla With Complement Factor H and Spore Persistence In The Lung
… mechanism to interact with the host complement system. The complement system is a crucial part of the host defense mechanism against foreign microorganisms. Knowledge of the specific interactions that occur between the complement system and <em>B. anthracis</em> was limited. Studies …
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Effect of Sialylation of Histophilus somni Lipooligosaccharide on Virulence and Resistance to Host Defenses
… of sialylation of Histophilus somni LOS on complement-mediated killing, binding of complement factor H (which converts C3b to inactive C3b (iC3b) and inhibit the alternative complement pathway) to the bacteria, complement activation by the LOS, and phagocytosis and killing of the bacteria by …
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The Development and Implementation of a TMT-SRM Assay for the Validation of Candidate Biomarkers of Alzheimer’s Disease
… panel of proteins included clusterin, complement C3, alpha-2- macroglobulin, gelsolin, fibrinogen gamma-chain, serum amyloid p-component and complement factor H. These proteins were previously found to be differentially expressed between plasma of Alzheimer’s disease subjects and …
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The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation
… E (apoE) has been identified as a predisposing factor for late-onset Alzheimer’s disease (AD). ApoE is known to interact with one of the classically characterized hallmarks of AD, the amyloid-beta (Aβ) protein. Aβ activates the classical complement pathway by binding to C1q that may sustain …
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Screen design for Borrelia burgdorferi lipoprotein secretion pathway components using periplasmic protein capture and suppressor mutations
… approaches. First, a mutational analysis of the complement binding protein CspA was performed with the aim to generate a subsurface mutant of CspA. CspA is a complement factor H binding protein that renders the bacteria serum-resistant. The resulting subsurface mutant would provide a basis for a …