Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"compensatory proliferation"”.
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Opposing Crosstalk between Rho1 and Cdc42 in Epithelial Morphogenesis
… complex as novel regulators of apoptosis-induced compensatory proliferation. Depletion or disruption of this complex from AJs induced JNK-dependent apoptosis and compensatory proliferation. This was mediated by increased Rho1-Rok activation downstream of Cdc42 depletion, and Rok's regulation of …
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Functional Restoration of Irradiated Salivary Glands Through Modulation of aPKCζ and Nuclear Yap in Salivary Progenitors
… population of murine salivary gland LRCs undergo compensatory proliferation in response to radiation. The initiation of compensatory proliferation is tightly associated with inactivation of the kinase aPKCζ and increased nuclear localization of YAP. This part of the study provides novel insights …
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Characterization of Stem Cell Turnover In A Living Epithelial Bilayer
… clearance of damaged basal stem cells promotes compensatory proliferation of neighboring stem cells to maintain overall population numbers in a bilayered epithelium. Time-lapse imaging and electron microscopy experiments reveal that dying cells are rapidly cleared as nearby basal cells engulf …
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A Signal to Divide: Apoptotic Extracellular Vesicles as Carriers of Mitogenic and Immunogenic Signals
… can signal to neighboring cells to stimulate proliferation and compensate for cell loss and maintain overall cell numbers in normal physiology and cancer. While dying cells can transmit instructive cues to neighboring cells, the molecular mechanisms that induce cell division are not well …
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Epithelial and immune cell dynamics in non-traditional models of mammary postnatal development
… rabbit mammary gland to interrogate epithelial proliferation and immune cell dynamics during mammary postnatal development and in mastitis. These species exhibit comparable histo-anatomy to the breast, constituting promising adjunctive non-traditional model systems. Moreover, unlike the male …