Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"common pathways"”.
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Gestational hypertension - common pathways with pre-eclampsia
abstract is not provided.
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Flavor Characterization of Broccoli Cultivars
… that SMCSO and aliphatic glucosinolates share common pathways in biosynthesis.
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Investigating the potential of enhanced neuroprotection through unfolded protein response inhibition and autophagy induction in neurodegeneration
… Despite their uniqueness, these PMDs share common pathways connected to their pathophysiology. Preclinical evidence demonstrates that these can be manipulated for new disease-modifying drug therapies. The unfolded protein response (UPR) and autophagy are two such pathways, whose …
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Visualizing the conversation pathways of telephone linked care in a directed graph
… particular way can be encoded to reveal the most common pathways through the tree. This paper describes a visualization application of TLC data which will allow researchers to gain new insights into the TLC conversations and into medical interviews in general.
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Modularity in Somatic Cell Reprogramming
… My observations suggest that numerous common pathways observed during reprogramming are implemented in varying temporal orders across distinct systems, and show that disparate/opposing developmental programs can co-exist within individual cells. By applying a barcoded, single …
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Early Outgrowth Cells As A Novel Therapy for Chronic Kidney Disease
… CKD is driven by the activation of several final common pathways of injury, including fibrosis and oxidative stress. If left unchecked, these inter-connected processes lead to progressive damage and subsequent organ dysfunction. Current clinical therapies, consisting of aggressive blood pressure …
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Pathosystems Biology: Computational Prediction and Analysis of Host-Pathogen Protein Interaction Networks
… for studying host-pathogen networks to identify common pathways perturbed and manipulated by pathogens. We present the first global comparison of the host-pathogen PPI networks of 190 different pathogens and their interactions with human proteins. We also present the construction and analysis of …
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Emotion Dysregulation and the Interpersonal Theory of Suicide in Adolescents
… is a promising theory that proposes three "final common pathways", perceived burdensomeness, thwarted belongingness, and acquired capability, as the most proximal risk factors to suicidal ideation and attempts. There is a growing body of literature that demonstrates that many known risk factors …
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Molecular analyses of endocrine and nutritional factors that affect division of labor and health in honey bees (Apis mellifera)
… these two physiological factors act through common pathways to regulate honey bee behavior. To provide greater mechanistic insights, in Chapter 3, I investigate a brain region, the pars intercerebralis, which is known to interact with nutritional cues and with juvenile hormone in other insect …
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Spatial Mapping in Wild White -Faced Capuchin Monkeys (Cebus Capucinus)
… map in which individuals use and reuse a set of common pathways and a select number of landmarks to reach a large number of targets. This research examines questions of primate cognitive ecology in wild white-faced capuchins (Cebus capucinus) in northeastern Costa Rica. First, I use a natural …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… or small molecule inhibitors that target common pathways of chemoresistance which include autophagy, upregulation of drug efflux pumps or the UPR network. It is clear that more research is needed in these areas in the hope to improve outcomes for obese, overweight and MRD risk patients and …
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PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
… substrate (IRS) has been one of the most common pathways in the establishment of insulin resistance (IR). Novel Protein kinase C (nPKC), is solely activated by diacylglycerol (DAG). Diacylglycerol has been found to be increased in the liver during NAFLD. Several studies have demonstrated a …
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Delineating The Mechanism(S) of Bdnf/Trkb Mediated Proliferation In Neuroblastoma
… MD/PhD</p> <p> Neuroblastoma is the most common extra-cranial solid tumor in children, arising from neural crest precursor cells. The neurotrophin receptors (TrkA/B/C) have been implicated as important prognostic markers, linking the biology of the tumor to patient outcome. High expression …
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Biobehavioral responses to immune skew and free fatty acids
… dependent on canonical proinflammatory signaling pathways (Toll-like receptor 4, Myeloid differentiation primary response gene 88, interleukin-1 receptor 1, interleukin-6, Tumor necrosis factor α) and was not PA specific. After resolution of acute effects, PA treated animals displayed anxiety-like …
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Growth Hormone and Melanin-Concentrating Hormone receptor in the regulation of energy balance and metabolism
… insulin secretion. Since leptin and MCH act in common pathways in the hypothalamus to regulate energy balance, leptin-deficient MCHr KO (MCHr KO ob/ob) mice were studied to investigate the importance of MCHr on the phenotype of ob/ob mice. MCHr KO ob/ob mice were similar to ob/ob mice concerning …
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Systems Biology Approach to Identifying Host Interactive Pathways Modulating the Severity of Streptococcal Sepsis
… was to identify additional host genes and pathways that may be modulating the severity of GAS sepsis.</p> <p>To achieve this goal I applied a systems genetics approach, involving genome wide association studies (GWAS) of GAS sepsis in the Advanced Recombinant Inbred (ARI) panel of BXD mouse …
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Risk assessment for family violence aggressors in Aotearoa New Zealand
… reported to police and identified four common pathways through the latent states over time. We concluded this manuscript by discussing changes that could contribute to improvements in how risk for FV aggressors is conceptualized, assessed, and communicated in practice. In each chapter, …
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The application of metabolomics in human health and disease
… tended to increase post treatment. The most common pathways affected were those of amino acid metabolism, lipid metabolism, nucleotide metabolism, polyketides, vitamins and cofactors, and xenobiotics, but the effect on carbohydrate metabolism was minimal. Finally, the study to ascertain …
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Assessment of Microbial Biodegradation of Mixed Soil Contaminants at the Santa Susan Field Laboratory Using TRFLP, qPCR, and Culturing
… in the literature review along with the most common pathways of biodegradation and degradation rates observed in field and laboratory studies.</p> <p>Soil was collected from 30 sample locations, with 3 sets of 10 samples containing high concentrations of one COI but low concentration of the …
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Exploring multivalency and chemical modifications in the development of anti-PD-L1 peptide inhibitors for cancer immunotherapy
… immune checkpoint axis is one of the most common pathways exploited by cancers to evade immune surveillance. Many cancers overexpress PD-L1 (programmed cell death ligand 1) on their surface through which they interact with PD-1 (programmed cell death protein 1) on activated immune cells, …