Global ETD Search
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Showing 1 to 8 of 8 for “"common fragile sites"”.
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Human common fragile sites, identification, and analysis of breaks using <i>saccharomyces cerevisiae</i>
<p>Common fragile sites, which are areas of the genome prone to breaks under replication stress, are frequently altered in tumor cells. Two hypotheses have been proposed to explain why common fragile sites break: (1)AT-rich segments with high flexibility in the fragile site fold into secondary …
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Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae
… may alter chromosome structure. Mammalian common fragile sites are the best-characterised, naturally occurring breakage-prone regions and are deleted or rearranged in many tumour cells. Analogous chromosomal regions also exist in the budding yeast, S. cerevisiae. One example of a yeast …
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DNA FRAGILE SITE BREAKAGE AS A MEASURE OF CHEMICAL EXPOSURE AND PREDICTOR OF THE SUSCEPTIBILITY TO FORM CHROMOSOMAL REARRANGEMENTS
… particularly susceptible to breakage termed “common fragile sites (CFS)”. To test the hypothesis that fragile site breakage underlies the formation of chromosomal rearrangements, we focused on RET/PTC rearrangements in papillary thyroid carcinoma. All genes participating in the two most common …
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Mechanistic Study of Fragile Site Breakage by Investigating RET/PTC Rearrangements, a Common Cause of Papillary Thyroid Carcinoma
Chromosomal fragile sites are non-random regions of the genome with a predisposition to the formation of DNA breaks. Common fragile sites, which are found in all individuals, often coincide with regions mutated in cancer, and therefore are believed to play a role in carcinogenesis. However, there …
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Human common fragile site FRA16D flexibility peak is not a strong mitotic: Recombination hotspot in <i>saccharomyces cerevisiae</i>
<p>Common fragile sites (CFS) are areas of the genome that tend to break when DNA replication is stressed or partially inhibited. Breaks at CFS can lead to gene deletions and amplifications that can result in the genesis of cancer cells. There is controversy about the mechanism of CFS instability. …
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The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability
… in potentially suppressing the expression of common fragile sites (CFSs) in response to replication stress, reflected by the increased mitotic CFS-characteristic chromosomal aberrations and MiDAS events at CFS loci observed in cells deficient in ZFP36L1. Finally, we also showed that a …
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Mechanistic Understanding of the Role of TRF1 in Telomere Replication
… fork stalling, sister telomere associations, and fragile telomeres. Fragile telomeres are structures that resemble common fragile sites (CFSs), but how they are formed is not known. TRF1 functions in part by recruiting the BLM helicase, which can resolve G-quadruplexes on the lagging-strand …
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The Origin of Genome Instability in Cancer: Role of the Fragile Site Gene Product FHIT
… genomic alterations are first seen at chromosome fragile sites. These fragile sites are exquisitely sensitive to agents that stress DNA replication forks, and thus, it is thought that replicative stress is a major source of genome instability in cancer. A frequent and very early genetic alteration …