Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"common diseases"”.
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Functional and cross-trait genetic architecture of common diseases and complex traits
… I introduce new methods for learning about diseases and traits from genetic data. First, I introduce a method for partitioning heritability by functional annotation from genome-wide association summary statistics, and I apply it to 17 diseases and traits and many different functional …
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Recessive and rare variant effects on common diseases and the immune cell transcriptome
… LoFs. Little is known about recessive effects on common diseases. Therefore, we searched for common and rare variants that had a recessive effect on common diseases in G&H. We imputed variants into 44,190 genotyped individuals, using two imputation panels: a set of 4,982 exomes from within the …
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Changes in the Oral Cavity and Common Diseases /// Промени в оралната среда и общи заболявания
… relationship of oral environment and common diseases. Our research shows that Candida flora sets itself in deep periodontal pockets in adults with chronic periodontitis. In children with renal disease incidence of Candida is higher than in controls. Unstimulated saliva contains viral …
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Developing a low-cost ceramic micro-porous water filter for removal of microorganisms that cause common diseases
Africa is one of the most water-scarce continents on earth and the lack of potable water is responsible for the death of approximately 4 900 children every day. Water can be effectively decontaminated by using a household ceramic water filter. The local production of low-cost water filters suitable …
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Lymph Nodes in Maxillofacial Surgery – In the Norm and Most Common Diseases // Лимфни възли в лицево-челюстната хирургия – в норма и най-чести заболявания
… function, and pathological changes in common diseases. A comprehensive analysis of patients with lymph node diseases of the head and neck, hospitalised and treated at the Clinic of Maxillofacial Surgery at St. Marina University Hospital – Varna, Bulgaria, for a ten-year period …
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Interpreting the role of non-coding genetic variation in human disease
… of associated phenotypes, suggesting human diseases are highly polygenic and that many additional regions remain to be discovered and characterized. Here, we address these challenges by using functional annotation of the human genome spanning diverse data types: epigenomic profiles, gene …
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Integration of common and rare genetic variation across complex traits and neuropsychiatric disorders
… have identified thousands of links between common variants and phenotypic outcomes. More recently, whole exome and genome sequencing has catalogued patterns of ultra-rare variation and associations with complex traits and diseases. However, there has been relatively little progress …
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Computational Contributions Towards Scalable and Efficient Genome-wide Association Methodology
… to conduct such comparative studies. For many common diseases, datasets as large as a hundred thousand individuals exist, each tested at million(s) of markers (called SNPs) across the genome. Despite this treasure trove, so far only a small fraction of the genetic markers underlying most common …
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The effect of self-monitoring and monetary incentives on the flossing rate of patients at a dental clinic
Epidemiological data reveal that one of the most common diseases in the world is dental disease. Scientific knowledge is available to prevent the vast majority of dental disease. Thus, individuals are not taking the necessary action to prevent caries and periodontal disease. Dental professionals …
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Interactions between influenza A virus and Streptococcus pneumoniae in nasal colonization and middle ear infection
… a leading cause of otitis media, one of the most common diseases of childhood. Despite this, the factors underlying its transition from colonizer to otopathogen are incompletely understood and are of great interest. Epidemiologically, coinfection with influenza A virus is strongly linked to the …
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Lysosomal nutrients and the mTORC1 pathway
… (mTOR) complex 1), and is often deregulated in common diseases, such as cancer. Given the critical role of lysosomes in maintaining cellular homeostasis, a better understanding of lysosomal function and metabolism and its relation to the mTOR pathway is necessary. Most components of the …
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Developing a gene model for simulations that incorporates multi-species conservation
… effect size of disease causing alleles for many common diseases including Type 2 Diabetes is not fully understood. Genetic simulations can be used to make predictions under specified genetic architecture models. Models whose predictions are inconsistent with empirical data can be rejected. We …
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An ultra-high throughput mutational spectrometer for human genetic diagnostics
Discovering the genetic causes of common diseases may require scanning for mutations in all of the genes in a million people, a significant undertaking. Such discoveries would revolutionize biotechnology, potentially enabling simple genetic tests for risk and targeted preventative or therapeutic …
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One hundred channel electrophoresis prototypes for application to an ultra-high throughput mutational spectrometer
… It is possible that with a correlation between diseases and the mutations that cause them, new therapeutic treatments could be developed against many of today's common diseases In order to accomplish mutation detection, 1012 gene segments may be needed, requiring a significant increase in …
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Predictive genomics in asthma management using probabilistic graphical models
… in progression and manifestation. Because most common diseases with high morbidity and mortality are complex traits, uncovering the genetic architecture of these traits is an important health problem. Asthma, a chronic inflammatory airway disease, is one such trait that affects over 300 million …
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Inherited risk for common disease
… discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular diseases, and diabetes. Such studies, however, depended on the untested assumption of monoallelic risk. …
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A GPU program to compute SNP-SNP interactions in genome-wide association studies
… algorithm is applied to the datasets of seven common diseases obtained from Wellcome Trust Case Control Consortium (WTCCC). The algorithm computed the significant SNP pairs much faster than the existing algorithms and also identifies 3 significant pairs associated with genes IL23R and C11orf30 …
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Investigation of hypothalamic molecular mechanisms underlying narcolepsy and obesity through DNMT1 and leptin receptor signalling
Sleep disorders and obesity are common diseases that can reduce the length or quality of life for millions of people. These diseases result in part from the dysfunction of cell populations in the hypothalamus that regulate the sleep/wake cycle and energy balance, respectively. There has been …
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The Development and Implementation of a Health and Wellness Ministry at the Open Door Church of Louisville in Louisville, Kentucky
… seeks to discuss health disparities and the most common diseases plaguing the African American community. Chapter 4 explains the process used in the implementation of the project. Chapter 5 focuses on analysis and evaluation of the project initiatives. This includes both successful and …
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A metabolic profiling approach to human disorders of energy metabolism
… disease - both rare, inherited disorders and common diseases such as diabetes mellitus. The study of metabolic disease depends upon quantitative methods which are traditionally custom-tailored to a given compound. Recent advances in technologies such as mass spectrometry now enable the …
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