Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"commensal microbiota"”.
-
AGE-RELATED GUT DYSBIOSIS ACCELERATES THYMIC INVOLUTION AND ALTERS PERIPHERAL T CELL REPERTOIRE IN DUCHENNE MUSCULAR DYSTROPHY
… systems have become increasingly linked to the microbiota, the microorganisms inhabiting the gut. For this purpose, we investigated the role of the commensal microbiota in exacerbating muscle damage via immune system activation. We created a network of expertise to characterize the intestinal …
-
Characterization of the intestinal microbiome and lactobacilli community: influence of dietary and environmental factors
… dense and diverse bacterial community called the commensal microbiota, which plays an important role in overall health of individuals. However, due to the extreme complexity of microbiota composition and limits of research tools, there were many challenges in identify and compare individual …
-
The Role of Dysfunctional Na+/H+ Exchange in the Development of Dysbiosis and Subsequent Colitis
… holds that IBD is an autoimmune attack on commensal microbiota, causing extensive collateral damage to the host intestinal tissues in the process. However, it has remained unclear in the field whether the changes observed in the IBD microbiome are causative in nature or whether the …
-
Factors Governing Gastrointestinal Colonization of Candida albicans
… hosts. Depletion of specific gut commensal microbiota is associated with or results in increased C. albicans burden in the gut and increased likelihood of dissemination in human patients and mice, respectively. The exact mechanisms by which gut microbiota mediate C. albicans …
-
Pathogenic Mechanisms Underlying Immune Dysregulation Associated To Hypomorphic RAG2 Mutation: Role Of Microbiota At Mucosal Interfaces
… deficiency alters the composition of the gut microbiota and causes bacterial translocation across the intestinal epithelium. Furthermore, loss of T cell tolerance to the commensal microbiota leads to gut inflammation sustained by Th1 and Th17 cells. Interestingly, we provided evidence that …
-
Exploiting Bacteriophages to Tackle Clostridium difficile Infection
… by culture, with no detrimental effect on commensal microbiota. The lysogenic capacity of ФCD27 appeared to prevent clearance of C. difficile in the models, but some strains containing the prophage exhibited reduced toxin production phenotypically. A possible mechanism of this altered …
-
Modulators of Innate Gut Immunity to Enteric Viral Infections: Murine Norovirus (MNV) as a Model
… system is constantly influenced, not only by the commensal microbiota, but also by the nutritional status of the host and the availability of certain essential micronutrients that are derived from a healthy-balanced diet. Additionally, age has a significant impact on the efficiency of gut immunity …
-
Limiting host-microbiota interactions to control intestinal inflammation
… tract lives in constant balance with the commensal microbiota residing in the intestinal lumen and immune responses must be tightly controlled. A strong intestinal barrier separates the immune system from resident microflora, and multiple mechanisms exist to reinforce the epithelium to …
-
CD4+ T cell response against food antigens in intestinal disease
… cytotoxic Th1 cells were also cross-reactive to commensal microbes, which are believed to be a direct trigger for altered CD4+ T cell responses in patients with Crohn's disease. This suggests that in this subgroup of CD patients, a network of cross-reactivities between commensal microbiota, …
-
The role of host and microbial factors in the pathogenesis of chronic schistosomiasis in mice
… in the complex tripartite interplays between the commensal microbiota, host's genetic factors, and immune response during helminth infections which are still poorly understood. The study explores this relationship in the context of chronic schistosomiasis-driven pathology. In the first part of the …
-
Response of intestinal Escherichia coli to dietary factors in the mouse intestine
Diet is a major force influencing the intestinal microbiota. This is obvious from drastic changes in microbiota composition after a dietary alteration. Due to the complexity of the commensal microbiota and the high inter-individual variability, little is known about the bacterial response at the …
-
Effect of cereal type and commensal bacteria on availability of methionine sources and intestinal physiology in pigs
… the contribution of the gastrointestinal microbiota to variation in bioefficacy of methionine sources and the interrelationship between intestinal microbiota and cereal grain type with respect to gastrointestinal physiology. Apparent gastrointestinal absorption of DL-methionine (MET) and …
-
Multi-omics investigation of interactions between persistent bacteria and Salmonella in the inflamed gut
… disease is performed absent complete native gut microbiota. Further, common murine models that could facilitate study of Salmonella in a robust community setting lack model-specific microbiome resources to accomplish the feat. Presented in this dissertation is a comprehensive catalogue of CBA/J …
-
Investigations into the Mechanisms that Are Responsible for Reduction in Colonic SN-38 Exposure
… SN-38 by bacterial β-glucuronidase secreted by commensal microbiota, generation of toxic active metabolite SN-38 from irinotecan mediated by intestinal carboxylesterse enzymes in gut and enterohepatic recycling of irinotecan and SN-38, etc., can contribute to the elevation of colonic SN-38 …
-
Sympathy for the Microbiota: How Changes in Gut Microbial Composition Influence the Immune System and Basic Physiology by Way of the Sympathetic Nervous System
… toxic substances or pathogens. Sensing of the microbiota has been previously shown to impact the intestinal immune and nervous systems, including crosstalk between the two. However, how microbes influence the enteric associated nervous system and whether these effects play a role in mediating …
-
Nutritional aspects and gut microbiota in paediatric inflammatory bowel disease
… strong evidence for the role of the indigenous microbiota and micronutrients in disease aetiology and mucosal injury, challenged the researcher to explore whether the action of EEN is mediated through changes in these parameters. This study aimed to assess aspects of the nutritional status of …
-
The role of probiotics, prebiotics, and human milk oligosaccharides in infant formulae
… tolerance and composition of the commensal microbiota, we assessed gastrointestinal tolerance and fecal microbiota, pH, and short-chain fatty acid (SCFA) concentrations of infants consuming formula with or without prebiotics in a second trial utilizing the a similar model as that …