Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"combinatorial therapy"”.
-
Immunotoxin Monotherapy and Combinatorial Therapy With Immune Checkpoint Inhibitors for Malignant Brain Tumors
… of care treatment (surgery, radiation, and chemotherapy) is less than 15 months. Medulloblastoma is another major malignant brain tumor that most frequently occurs in children. Although recent advances in surgery, radiotherapy, and chemotherapy have led to an increase in 5-year survival rates of …
-
Combinatorial therapy for triple negative breast cancer and the effect of nanoscale surfaces
… TNBC pushed the researchers to explore combinatorial therapy regime. A combination of STAT-3 specific inhibitor, reported to act synergistically with metformin in reducing cell growth and inducing apoptosis in TNBCs and agents targeting DNA repair, can produce a new approach to TNBC …
-
Basis For Targeting Met Activation Mediated Resistance to Pi3K Inhibition In Breast Cancer
… targeting each pathway, and that combination therapy targeting the PI3K and MET pathway will optimize therapy-effect by preventing the acquisition of resistance.</p> <p>We analyzed cMET and phospho-cMET levels in 257 breast cancer samples and found that high levels of both the proteins were …
-
The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours
… options are restricted to surgery and radiotherapy, which are invasive and may cause further tumour development. The activity of both the E3 ubiquitin ligase complex Cullin 4 really interesting new gene (RING) E3 ubiquitin ligase- DNA damage binding protein (DDB1) and Cullin 4 associated …
-
Investigating the Anti-Melanoma Activity of Combinatorial Paclitaxel and MEK Inhibitor
… many of the existing shortcomings in cancer therapy. Combination of more than one drug may maximise the therapeutic response and minimise undesirable effects of the chemotherapeutic agents in cancer patients.<br/><br/>I developed a novel combinatorial approach that can be loaded into targeted …
-
Combinatorial Treatments and Technologies for Safe and Effective Targeting of Malignant Gliomas Using High-Frequency Irreversible Electroporation
… into improved efficacy when administering the therapy in conjunction with other treatment forms and technologies. Specifically, the presented work focuses on several key areas: (1) determining the effect of pulsing protocol and geometric configuration selection on the biological outcomes from …
-
Normal Glycolytic Enzyme Activity Is Critical For Hypoxia Inducible Factor-1A Activity and Provides Novel Targets For Inhibiting Tumor Growth
… stress survival pathways to be used as a combinatorial therapy for patients in which tumor hypoxia has rendered standard therapeutic tools ineffective.</p>
-
The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… of cancer-related deaths due to conventional therapy resistance and metastatic disease, therefore understanding the mechanisms governing these biological functions is vital for improving patient survival. Approximately 30% of patients with the adenocarcinoma histologic subset of lung cancer …
-
Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
… possibly oral administration, stockpiling, combinatorial therapy. (+)ssRNA helicases, essential for viral replication, are among the most conserved proteins across several viral families, are a molecular class still underexplored, that lacks approved antiviral agents. In this respect, the …
-
Mammalian genome engineering: Fundamental investigation and method development
… a multi-factorial Ischemia engineered cell-therapy using CRISPR/Cas9-based gene activation systems. I used synthetic biology tools that can be controlled by chemical ligands to. Temporally induce three important growth factors that control the process of blood-vessel maturation in case of an …
-
ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… of identified ‘hit’ DUBs might be suitable as a combinatorial therapy with MEK1/2 or mTOR inhibitors in the treatment of cancer. The RNAi screen identified several DUBs, that, when knocked down, sensitised HCT116 cells to MEK1/2 inhibitor treatment and enhanced MEK1/2 inhibitor induced cell death …
-
Engineering Tumor-Targeting Bacteria and Characterizing Their Interactions with Tumor Cells in Therapy-Resistant Breast Cancers
… drops from >90% in early-stage BC to ~32% for therapy-resistant subtypes such as triple-negative (TNBC), hormone-receptor–variable or resistant ER+, and Luminal B tumors. For these high-risk subtypes, molecular heterogeneity undermines targeted therapies, and clinical management still relies on …