Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"combinatorial screening"”.
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Microfluidic chips for combinatorial screening applications
… systems have the ability to duplicate benchtop screening experiments with the same fidelity at much smaller scales. Microscale experiments also have the benefit of using very little precious reagent, giving the economic value of low volume usage. In order to develop high density microscale …
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Degenerate oligonucleotide primed amplification of genomic DNA for combinatorial screening libraries and strain enrichment
Combinatorial approaches in metabolic engineering can make use of randomized mutations and/or overexpression of randomized DNA fragments. When DNA fragments are obtained from a common genome or metagenome and packaged into the same expression vector, this is referred to as a DNA library. Generating …
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Developing Low Fouling Peptides and Zwitterionic Materials for Biomedical Applications
… to rational and biomimetic peptide design, a combinatorial screening method was explored to facilitate the testing of thousands of peptide sequences for low protein adsorption. Finally, zwitterionic polymers were explored to form particles for mucus-penetrating applications.
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Developing Time-Resolved Synchrotron Infrared Spectroscopy for Spectroelectrochemical Measurements
… proof-of-principle for its capability for combinatorial screening for binary electrocatalysts. The thesis discusses the development of time-resolved step scan FTIR in attenuated total reflection - surface enhancing infrared absorption spectroscopy configuration (ATR-SEIRAS) to improve …
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Discovery of Molecules that Modulate Protein-Protein Interactions in the Context of Human Proliferating Cell Nuclear Antigen-Associated Processes of DNA Replication and Damage Repair
… ligand. A novel in silico multi-fragment, combinatorial screening approach was used to guide the selection and subsequent synthesis of tripeptoid ligands, which were evaluated in a PCNA-based competitive displacement assay. From the results, some of the peptoid-based compounds that were …
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Synthetic Peptide Ligand Mimetics and Tumor Cell Motility
… matrix and migrate to distant locations. Using a combinatorial screening approach, six novel D-amino acid containing peptides were identified and analyzed for their ability to adhere to human prostate tumor cells, support tumor cell adhesion and inhibit tumor cell adhesion to ECM proteins. Two …
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BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER
… of bioactive compounds in a high throughput combinatorial screening. From this experiment, it emerged that inhibition of BET (bromodomain-extra-terminal domain) proteins robustly synergized with ASO antiC in reducing ALT cells proliferation. Moreover, the inhibition of these epigenetic …
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DNA Three-way Junctions as Scaffolds for Hybrid Catalysis
… approach incorporating computer simulation. Combinatorial experiments demonstrate a new method for producing variation in modified functional DNA nanostructures, and eight modified DNA junctions were studied for esterase-like activity. Kinetic experiments found seven variants of imidazole …
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Biologically inspired materials for electro-responsive coatings and the photo-oxidation of water
… and yeast display libraries have enabled the combinatorial screening of peptides against a multitude of materials to which natural systems typically have no exposure. These techniques have yielded peptides that can bind and assemble technologically relevant materials such as gold and CdS. In …
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From atoms to cities : A bottom-up analysis of infrastructure materials and systems
… combining the tool of statistical physics with combinatorial screening technique, we first construct a database of realistic molecular structures of C-S-H with varying calcium-to-silicon ratios and compare them against an extensive array of nanotextural and nano-mechanical experiments. A …
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Microfluidic platforms for solid form screening of pharmaceutical parent compounds
Solid form screening and selection of pharmaceutical parent compounds (PCs) has been identified as a critical step in the early stages of drug development. A significant fraction of candidate PCs are rejected on account of poor physicochemical properties that affect their biopharmaceutical …