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Showing 1 to 5 of 5 for “"combinatorial biosynthesis"”.
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Discovery and structural characterization of lanthipeptides from soil and rumen bacteria
… as well as the enzymes that execute their biosynthesis. The contents of this thesis are focused on the discovery of lanthipeptides using a variety of methods. Chapters 2 and 4 demonstrate the application of heterologous expression of gene clusters to produce lanthipeptides. The resulting …
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Mechanistic Studies of Lantibiotic Biosynthetic Enzymes and Discovery of Novel Lanthionine-Containing Peptides
… representing an impressive case of natural combinatorial biosynthesis. The thioether ring topologies were determined for several of the prochlorosins. Finally, we demonstrate the initial characterization of a LanM-like enzyme containing a serine/threonine protein kinase domain, and describe …
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Total Synthesis of Naturally Occurring Antimicrobial Peptides
… chemoenzymatic synthesis, semi-synthesis, and combinatorial biosynthesis only produced a very limited number of daptomycin analogues, leaving much of the chemical space unexplored. A de novo solid-phase synthesis of daptomycin via Boc chemistry was achieved. The challenging ester bond formation …
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Forward and reverse genetic approaches to investigate cellulose biosynthesis in Physcomitrium patens
Cellulose biosynthesis is a common feature of land plants and involves multimeric complexes composed of cellulose synthase A (CESA) proteins and other structural proteins. The exact stoichiometry of CESA proteins and interactions among proteins within cellulose synthase complex (CSC) is not well …
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Biochemical characterization of enzymes involved in the post-translational modification of lantibiotics
The student, Manuel Ortega, accepted the attached license on 2015-11-05 at 09:42.