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Showing 1 to 2 of 2 for “"combinatorial biocatalysis"”.
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Expression, Reinigung und Charakterisierung von Makrolid-Glykosyltransferasen für die Synthese neuartiger Makrolid-Antibiotika
… the synthesis of novel macrolide antibiotics by combinatorial biocatalysis a system was examined that combines the in situ regeneration of nucleotide activated deoxysugars from dTDP and sucrose with the glycosylation of an acceptor molecule. In this system EryCIII was successfully used for the …
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Entwicklung eines Enzym-Modul-Systems zur Synthese und in situ Regeneration von dTDP-aktivierten Desoxyzuckern
The results of this thesis showed for the first time that it is possible to produce glycosylated natural compounds in vitro with in situ regeneration of dTDP-activated deoxysugars. The deoxysugar biosynthesis genes from the avilamycine- (aviS, aviT), urdamycine- (urdR) and midekamycine-biosynthesis …