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Showing 1 to 20 of 47 for “"combinatorial approach"”.
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A Combinatorial Approach to Nearly Uncoupled Markov Chains
A discrete-time Markov chain on a state space S is a sequence of random variables X = fx0; x1; : : :g that take on values in S. A Markov chain is a model of a system which changes or evolves over time; the random variable xt is the state of the system at time t. A subset E � S is referred to as an …
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Construction of Reliable Series-Parallel Networks: A Combinatorial Approach
The study of network reliability is motivated practically by the appearance of more and more large- and medium-scale networks, and by every indication that the computer network will soon be a primary means of communication for most people. For sparse networks, the probability that the network is …
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Analysis of a combinatorial approach to the travelling salesman problem
Ch. 1. Introduction -- Ch. 2. Some results concerning p-optimality -- Ch. 3. Algorithms for the travelling salesman problem -- Ch. 4. Discussion.
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A combinatorial approach to goal-oriented optimal Bayesian experimental design
… and propose several algorithms for solving the combinatorial problem of observation selection/optimal experimental design in a goal-oriented setting. Here, the quantity of interest (QoI) is not the model parameters, but some (vector-valued) function of the parameters. We wish to select a subset …
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Combinatorial approach to multi-substituted 1,4-Benzodiazepines as novel non-peptide CCK-antagonists
… were prepared by a 5-step solid phase combinatorial approach. Substituents were varied in the 3,5, 7 and 8-position on the benzodiazepine scaffold. The combinatorial library was evaluated in a CCK radiolabelled binding assay and CCKA (alimentary) and CCKB (brain) selective lead …
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A combinatorial approach to the search for anticonvulsant agents from gou teng and tian ma
About 40% epileptic patients are refractory to current therapeutics, thus the discovery of new antiepileptic agents is urgently needed. Gou Teng and Tian Ma are two famous Traditional Chinese Medicines (TCMs) widely used in the treatment of epilepsy. Some oxindole alkaloids of Gou Teng have been …
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A combinatorial approach for improved target prediction, validation, and characterization of small RNAs in Escherichia coli
… Targets/Total Known targets). We employed a combinatorial approach combining both SPOT and experimental evidence to identify potentially overlooked targets for the well-characterized sRNAs Spot42, SgrS, GcvB, and RyhB. We constructed a tiered ranking system with strict criteria to produce an …
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A combinatorial approach to the chemical synthesis and biological evaluation of 3,4,5-trisubstiituted furan-2(5H)-ones
… this molecule lends itself to manipulation using combinatorial techniques due to the presence of more than one site for the attachment of different suhstituents. By developing different reaction schemes at the three sites available for attachment on the furan-2(5H)-one scaffold, combinatorial …
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A combinatorial approach to scientific exploration of gene expression data: An integrative method using Formal Concept Analysis for the comparative analysis of microarray data
Functional genetics is the study of the genes present in a genome of an organism, the complex interplay of all genes and their environment being the primary focus of study. The motivation for such studies is the premise that gene expression patterns in a cell are characteristic of its current …
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Effects of electrical stimulation and testosterone on regeneration-associated gene expression and functional recovery in a rat model of sciatic nerve crush injury
… functional recovery will require the use of a combinatorial approach that can simultaneously target different aspects of the post-injury response. In general, the concept of a combinatorial approach to neural repair has been established in the scientific literature but has yet to be …
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The Interrogation of Cas9 Aptamers and sgRNA Structures Through SELEX
… of altering the sgRNA . Second, we use a novel combinatorial approach that utilizes a functional SELEX (Systematic Evolution of Ligands by Exponential Enrichment) to identify numerous, diverse sgRNA variants that bind S. pyogenes Cas9 and support DNA cleavage. These variants demonstrate …
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SYNTHESIS OF NOVEL BODIPY LIBRARIES AND THEIR APPLICATION IN BIOIMAGING
… towards sensor development. We first applied a combinatorial approach to construct diversity-oriented fluorescent libraries as chemical tool box based on BODIPY fluorophore. These novel BODIPY libraries were then carried out in both unbiased in vitro screening and cell-based screening systems. …
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Information Network Design for Lean Logistics
… for policy development. We provide a structured approach for policy design, which doesn't rely on any simulation experiments. Further, we study the impact that information network design has on the response of supply chains. We use a combinatorial approach to develop guidelines for information …
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Oncolytic viruses enhance long-term NK cell anti-tumor cytotoxicity through AP-1 and IRF pathway activation
… underscoring the therapeutic potential of this approach. Mechanistically, enhanced NK cell effector function was governed by the activation of the AP-1 family transcription factors, while long-term cytotoxicity was associated with upregulation of the IRF family of transcription factors through …
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SALICYLALDEHYDE-TAGGED PEPTIDES FOR THE REVERSIBLE-COVALENT ENGAGEMENT OF PROTEIN LYSINE RESIDUES
… discovery has recently re-emerged as a powerful approach for targeting clinically-relevant proteins, offering enhanced potency and selectivity through controlled covalent interactions. In particular, reversible covalent (RC) chemistry combines the strength of covalent binding with the tunability …
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New Organic/inorganic Hybrid Sol-gel Nanocomposite Materials For Raman Gain In Fiber Optics
… methodology developed facilitates the systematic approach to produce sol-gel derivatives with functional groups known to be strongly Raman scattering. Additionally, a method to synthesize and characterize a large number of different compounds using a combinatorial approach was demonstrated. Thio …
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Screening, synthesis, and applications of "lipidoids", a novel class of molecules developed for the delivery of RNAi therapeutics
… We have developed chemical methods using a combinatorial approach that has resulted in the synthesis of a large library of structurally-diverse compounds (1,200 in total), termed "lipidoids", without the need to use solvents, catalysts, or protection/deprotection steps. The members of this …
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Towards incorporation of catalytic function into small folded peptide scaffolds
… describes the development of iterative and combinatorial methods for identifying small peptide scaffolds able to support catalytic function. The incorporation of thiamine coenzyme functionality into small peptide scaffolds is achieved through the use of a coenzyme amino acid chimera (Taz). …
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COMBINATORIAL DEVELOPMENT OF NANOSTRUCTURED MATERIAL LIBRARIES FOR THE STUDY OF CELL SUBSTRATE INTERACTION
… cell adhesion and growth. Here we described a combinatorial approach to construct libraries of metals comprising 54 physicochemical combinations induced by surface chemistry and topography. In addition the surface properties including surface topography, surface chemistry, and wettability were …
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