Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"combinational therapy"”.
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Combinational Therapy to Mitigate α-Dicarbonyl Toxicity
… of methylglyoxal stress. In this work, we pursue combinational therapy to identify a more effective approach at mitigating neurotoxicity. We show that a five-compound combination ameliorates methylglyoxal stress in multiple dopaminergic cell lines: N27, PC12 and SH-SY5Y. Results indicate that …
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17-AAG and sihsp90α combinational therapy as a novel anti-cancer approach
… h post serum exposure. Finally, the combination therapy induced hsp90α knockdown and reduced Akt kinase activity in vivo. Although these results are preliminary and requires further validation, the anti-cancer activity is promising. These results suggest that the combination treatment with …
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Proteasome Inhibition Enhances The Effect of Bikdd Gene Therapy
… study, we proposed proteasome inhibition as a combinational therapy strategy with BikDD gene therapy to enhance the clinical benefits. Proteasome inhibition stabilized exogenously expressed BikDD protein, and significantly enhanced the apoptosis induction effect of BikDD. Studies on detailed …
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Polyomavirus Enhancer Activator 3 (PEA3), a Member of the Ets Family of Transcription Factors, Is a Transcriptional Activator of Notch-1 and Notch-4 in Breast Cancer: An Opportunity for Novel Combinational Therapy
<p>Women diagnosed with triple-negative breast cancer have the worst overall prognosis and frequently present with metastatic tumors. To date, there are no targeted therapies available to combat this aggressive form of breast cancer due to the lack of expression of well-known targets such as …
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Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… environment or cancer treatments such as chemotherapy and evade cell death. A better understanding of how drugs that perturb autophagy affect cancer cell signaling is of critical importance toimprove the cancer treatment arsenal.</p> <p>In order to gain insights in the relationship between …
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Exploring vasculogenic mimicry and anti-angiogenic therapy resistance within breast cancer patient-derived tissue xenograft models
… tumour neovascularisation with anti-angiogenic therapy (AAT) holds much promise to halt tumour growth and inhibit metastasis, however AAT trials have not delivered the predicted clinical success in a large amount of the cancer types tested, including breast cancer. It has become increasingly …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
Glioblastoma (GBM) is an aggressive and the most prevalent form of brain tumour. It is characterized by high intertumoral and intratumoral heterogeneity and a low survival rate. Since 2005, the current gold standard of care for treating newly diagnosed GBM has remained the same: maximal safe …