Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 204 for “"combination therapy"”.
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Combination Therapy For the Treatment of Human Malignant Neuroblastoma
… therapeutic approaches including chemotherapy, radiation therapy, immunotherapy, and neurosurgery, the survival rate of children affected with advanced stage neuroblastoma remains significantly low. Therefore, there is an urgent need to develop innovative therapeutic approaches to …
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Survivin: Regulation by YY1 and Role in Pancreatic Cancer Combination Therapy
… importance to improving cancer management and therapy. Our work has identified a novel transcriptional regulator of survivin called Yin Yang 1 (YY1). YY1 is a transcription factor that has been observed to activate some gene promoters and repress others, and it is gaining increasing interest as …
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Combination therapy studies with the vascular disruptive agent combretastatin-a4-phosphate (CA4P)
… This thesis examined the feasibility of CA4P combination therapy, examining the hypothesis that two agents may be additive or synergistic, eliminating separate tumour cell subpopulations and thus increasing the effectiveness of both drugs. Chemotherapy using paclitaxel & carboplatin …
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Interleukin-15 and [alpha](1,3)galactosyl-expressing vaccine combination therapy for melanoma
… cells (B16IL-15) were administered to mice in combination with the B16aGal vaccine with or without B16N/V vaccine cells (irradiated B16F0 melanoma cells). As documented in literature, IL-15 stimulates the proliferation and maintenance of memory CD8+ T cells. We exploited these effects of IL-15 …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… for growth, and the goal of anti-angiogenic therapy is to destroy the tumor vasculature. Recent findings suggest that anti-angiogenic therapy enhances radiation and chemotherapy responses. These findings seem paradoxical, since anti-angiogenic therapy prunes tumor vasculature while …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
… rendering cancer cells resistant to PARPi. The combination of c-Met inhibitors (METi) and PARPi has a synergistic effect for c-Met overexpressed TNBC <em>in vitro</em> and <em>in vivo</em>. In addition to c-Met, through functional analysis, we found casein kinase 2 (CK2) is another potential …
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Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts
… lung function, especially when administered in combination. Airway remodeling is relatively resistant to treatment with GC, but may respond better if treated with a combination of GC and LABA. The results from this thesis, suggest that indeed, combination of GC and LABA, via complementary and …
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A COMBINATION THERAPY OF NICOTINAMIDE AND PROGESTERONE FOR FUNCTIONAL RECOVERY FOLLOWING TRAUMATIC BRAIN INJURY
… of function in an animal model of TBI after combination treatment of both NAM and Prog. Animals received a cortical contusion injury over the sensorimotor cortex and were treated with either nicotinamide (75 mg/kg, i.p. NAM loading dose, 12 mg/kg/hr NAM, s.c. over 72 hrs), Prog (10 mg/kg …
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Central mechanisms underlying the synergistic anorectic effect of CCK and GLP-1 combination therapy
Combination therapies that enhance the effects of separate peptides while limiting adverse effects constitute a promising strategy to improve the efficacy of pharmacologic-based treatments of diabetes and obesity. Cholecystokinin (CCK) and Glucagon-like peptide-1 (GLP-1) are gut hormones produced …
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The Exploration of a Combination Therapy on Voice Feminization for Male-to-Female Transgender Individuals
… results added to the dearth of research on vocal therapy interventions provided by speech-language pathologists to transgender clients. Second, it piloted the Combination Voice and Communication (CVC) therapy to better understand the components of this therapy related to the feminization of the …
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Combination Therapy With Aerosol Il-2 and Nk Cells For The Treatment of Osteosarcoma Lung Metastasis
… efficacy of combining natural killer [NK] cell therapy with aerosol interleukin-2 [IL-2] for the treatment of osteosarcoma lung metastasis. The expression of NKG2D ligands was analyzed in five different human osteosarcoma cell lines and 103 patient samples (47 from primary tumors and 56 from …
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Malaria treatment seeking behaviour and access to artemisinin combination therapy : a case of Mushin, Lagos, Nigeria
ACTs have been shown to be effective in treating malaria and are currently recommended as first-line drugs for the treatment of uncomplicated malaria in Nigeria because of resistance of malaria to chloroquine (CQ) and sulphadoxine pyrimethamine (SP). However, very little is known about malaria and …
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Artemisinin-Based Combination Therapy (ACTs) Drug Resistance Trends in <em>Plasmodium falciparum</em> Isolates in Southeast Asia
Plasmodium falciparum, one of the parasites that cause clinical malaria, is a continuous public health concern, especially in Asia and Africa. Unfortunately, the parasite has developed resistance to many drugs created to treat and prevent the disease. Artemisinin and its derivatives are the new …
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Exploring the Potential use of TEAD Inhibition as Part of a Combination Therapy for NF2-Deficient Schwannoma and Meningioma.
… Although surgical resection and adjuvant radiotherapy can be used, new avenues of therapeutic development are essential to target inoperable and recurrent tumours. Previous studies evaluating small molecule TEAD auto-palmitoylation inhibitors have distinguished their anti-proliferative effect …
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Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin
… treatment has been constantly improved. Today a combination therapy with pegylated interferon a (PEG-IFN) and ribavirin is recommended. The sustained virological response rate six months after stop of treatment (SVR) is about > 55% in treatment naive patients. Because the treatment with PEG-IFN …
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The Biological and Immunological Effects of Irreversible Electroporation and Combination Therapy Options for the Improving the Treatment of Pancreatic Cancer
… cancer remains a lethal cancer with few therapy options available. This is due to the inaccessibility of the tumor by surgical and thermal ablative means, high potential for chemoresistance and metastasis, and strongly immunosuppressive tumor microenvironment that makes new treatment …
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Cost effectiveness analysis of abacavirlamivudine versus tenofoviremtricitabine combination therapy as part of highly active antiretroviral therapy in treatment naive HIV-infected patients
Introduction: Current recommendations for the treatment of HIV include the use of dual nucleoside reverse transcriptase inhibitors, namely abacavir/lamivudine or tenofovir/emtricitabine. This study is to compare the cost-effectiveness of these two alternatives in the treatment of HIV …
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An Innovative Phase I Trial Design Allowing For The Identification of Multiple Potential Maximum to lerated Doses With Combination Therapy of Targeted Agents
Treatment for cancer often involves combination therapies used both in medical practice and clinical trials. Korn and Simon listed three reasons for the utility of combinations: 1) biochemical synergism, 2) differential susceptibility of tumor cells to different agents, and 3) higher achievable …
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PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy
… to kill and are thought to prolong TB pharmacotherapy. Spectinamide 1599 is a synthetic modification of spectinomycin that has demonstrated excellent preclinical drug like properties such as excellent in vivo efficacy, strong efficacy against clinical MDR isolates, lack of cross resistance, …
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