Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"combination regimen"”.
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Utilization of Proton Pump Inhibitors in Combination Regimen for Breast Cancer Treatment by Targeting Fatty Acid Synthase
… drug resistance in cancer cells when used in combination with other chemotherapeutics, although the mechanism of resistance reduction is uncertain. In our lab, previous investigation showed that PPIs decreased FASN thioesterase (TE) domain activity and cancer cell proliferation in a …
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A scoping review on the use of telerehabilitation in physiotherapy in low and middle income countries
… drug, administered as part of a fixed-dose combination regimen for the treatment of tuberculosis (TB). Individuals with comorbid HIV have reported reduced serum concentrations of ethambutol. We aimed to evaluate the pharmacokinetics of ethambutol in individuals with both drug-susceptible TB …
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Efficacy and safety of novel and repurposed drugs for the treatment of drug-resistant tuberculosis
… TB patients who received programmatic treatment regimens with the backbone of second line injectables and fluoroquinolones (nonbedaquiline-based) and those who received a bedaquiline- and/ or linezolid-based treatment regimen. The second study determined the frequency of system-specific adverse …
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Development of orthogonal nanotherapeutics for colorectal cancer treatment
… wild-type colorectal cancer model.<br/><br/>The combination of therapies that work by different modes of action is a standard regimen in the clinic for the treatment of many cancer. Although the combination regimen of RG7388 and Entinostat holds promising outcomes, the administration of such …
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Rates of Switching First-Line Antiretroviral Regimen Tenofovir-Emtricitabine-Efavirenz combination in a Primary Care Service in South Africa
… (TEE) fixed-dose-combination (FDC) has been recommended since 2013 as the first-line antiretroviral therapy (ART) for treating HIV for people living with the virus (PLWH) in South Africa. More evidence has emerged to show long term adverse effects of Efavirenz(EFV). …
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Barriers to tuberculosis drug discovery: the mycobacterial cell wall
… side effects associated with the multidrug combination regimen. As such, rational drug design to develop more potent, faster-acting anti-TB compounds requires a comprehensive understanding of the composition and functioning of the mycobacterial cell envelope to ensure effective penetration …
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Prevalence and incidence of hypertension and diabetes mellitus in HIV infected persons on HAART in Chongwe district in Lusaka province.
… determinants T2DM and hypertension show that ART combination (p=0.001), age category (p=0.011) and cigarette smoking (p=0.0460) significantly added to the prediction model for T2DM outcome; and that ART combination (p=0.004), sex (p=0.001), family history of hypertension (p=0.007) and cigarette …
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Prevalence and incidence of hypertension and diabetes mellitus in HIV infected persons on HAART in Chongwe district in Lusaka province.
… determinants T2DM and hypertension show that ART combination (p=0.001), age category (p=0.011) and cigarette smoking (p=0.0460) significantly added to the prediction model for T2DM outcome; and that ART combination (p=0.004), sex (p=0.001), family history of hypertension (p=0.007) and cigarette …
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Identifying cross-species regimens for the treatment of rapid-growing and slow-growing nontuberculous Mycobacterium pulmonary infections
… drugs were evaluated for repurposing to develop regimens with activity across diverse NTM pathogens. Comparative genomics using the Distilled Refined Annotation of Metabolism (DRAM) tool demonstrated that bioenergetic pathways, including oxidative phosphorylation and central carbon metabolism, …
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Discovery of Dihydroartemisinin and Dasatinib Drug Combination to Cure Pooroutcome BCR-ABL+ Acute Lymphoblastic Leukemia
… to tackle drug resistance. To identify combination agents that could overcome the dasatinib-resistant phenotypes of Ph+ ALL, we screened a library of 3200 agents including known anti-infective and chemotherapy drugs. We discovered that a well known antimalarial drug dihydroartemisinin …
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Utilization of Model-Based Approaches to Maximize Efficacy of Antibiotics for the Treatment of Mycobacterium abscessus Pulmonary Infection
… generally more than 12 months with a multidrug combination of at least four agents. However, no optimal combination, regimen, or treatment duration has been universally established for Mab pulmonary infections (Mab-PI). Therefore, the selective and strategic use of the most potent agents …
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Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24
… cancer. Thus, Ad.5/3-mda-7, alone and/or in combination with BI-97C1 (Sabutoclax), might represent an improved and more effective therapeutic approach for colorectal and other cancers. In view of the essential roles of anti-apoptotic Bcl-2 family proteins in tumorigenesis and chemoresistance, …
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Comparative Effectiveness of Methotrexate-Based Disease-Modifying Antirheumatic Drug Combinations for Rheumatoid Arthritis
… disease-modifying antirheumatic drugs (DMARDs) combinations, including csDMARDs plus MTX, TNFi plus MTX, non-TNFi biologics plus MTX or tsDMARDs plus MTX in RA; [3] to examine the risk of cardiovascular (CV) events associated with different types of DMARDs exposure in RA, focusing on individual …