Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"combination chemotherapy"”.
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Development of PAC-1 as a privileged agent for combination chemotherapy
… Described herein is the evaluation of PAC-1 in combination with diverse chemotherapeutics, and leveraged for the treatment of challenging cancers. Concurrent external development of a second class of mechanistically-distinct procaspase-3 activating compounds, enabled a proof-of-concept …
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A novel nanoscale delivery system for spatio-temporal delivery of combination chemotherapy
… treatments for cancer, the emerging model is the combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood vessel growth. However, the implementation of this strategy has faced two major obstacles. First, the long-term shutdown of tumor blood vessels by the …
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Combination Chemotherapy and In vivo Modeling of BRCA-deficient, High-grade Serous Ovarian Cancer
… disease. Mutations in a number of homologous recombination repair genes have been implicated in hereditary ovarian and breast cancer. Specifically, over half of ovarian cancer cases exhibit BRCA-deficiency by either germ line or somatic mutation, or epigenetic silencing. The importance of …
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Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential
… fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are important …
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Discovery of Pyrimidine-based Heterocycles as Single Agents With Combination Chemotherapy Potential And As Inhibitors Of Purine Nucleotide Biosynthesis For The Treatment of Cancer
… heterocycles as single agents with combination chemotherapy potential having both antiangiogenic effects and cytotoxic effects. This dissertation also describes selective tumor targeting with 5-substituted pyrrolo[2,3-<em>d</em>]pyrimidines analogs with heteroatom bridge …
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Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase
… single agents and tubulin inhibitors in cancer chemotherapy and selective Toxoplasma gondii TS inhibitors for the treatment of toxoplasmosis.</p><p> Tubulin inhibitors are important antitumor agents that disrupt microtubule dynamics. Thymidylate synthase (TS) inhibitors prevent cell division by …
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An analytics approach to designing clinical trials for cancer
Since chemotherapy began as a treatment for cancer in the 1940s, cancer drug development has become a multi-billion dollar industry. Combination chemotherapy remains the leading treatment for advanced cancers, and cancer drug research and clinical trials are enormous expenses for pharmaceutical …
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Oncofetal Proteins Drive Aggressive Disease in Basal Pancreatic Cancer
… only treatment option for advanced disease is combination chemotherapy. Targeted small molecule inhibitors and immunotherapies have encountered rapid resistance and are not yet clinically approved. Identifying disease subtypes and targeting therapies to these subtypes remains of crucial …
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The Effect Of Leucogenenol and Chemotherapy on B and T Lymphocyte Populations in Mice Infected With Friend Virus Leukemia
… of the immunostimulant leucogenenol and the combination chemotherapy of arabinosyl cytosine and vinblastine on the Band T lymphocyte populations of mice infected with Friend virus leukemia. Procedure. Isolated lymphocyte populations were quantitated using a cytotoxic assay for T lymphs and a …
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Formulation of targeted drug-loaded nanoparticles for lung cancer therapy
The use of combination chemotherapy for treatment of lung cancer has been proven to be more effective than single-agent therapy. Such combination, when used in conjunction with nanoparticle carriers has the potential to effectively deliver the therapeutic payload to the cancer sites with minimal …
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Effect of combinations of drugs on glioma chemotherapy
Recent developments in chemotherapy have improved the survival rates as well as the quality of life of patients with glioma. Combination chemotherapy regimens along with the use of two or more anticancer agents or with the use of various drug delivery systems have become a major component of …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… patients will develop resistance to DNA-damaging chemotherapy and relapse. Recent studies indicate that RNA-binding proteins (RBPs) appear to play a particularly important role in cancer, and may contribute to chemoresistance, but the field is still at an early stage and nothing has yet progressed …
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… heterocycles as a) single agents with combination chemotherapy potential having dual antiangiogenic effects and cytotoxic effects or b) one-carbon metabolism inhibitors for targeted tumor therapy; or c) selective <em>Pneumocystis jirovecii </em>(pj)<em> </em>dihydrofolate reductase …
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ATR SIGNALING IN GENOME REPLICATION AND MAINTENANCE
… the ability of cells to utilize homologous recombination (HR)-mediated DNA repair. Proteomic analysis revealed that chronic ATR inhibition reduces the abundance of key HR factors, suggesting that spontaneous ATR signaling promotes enhanced HR capacity by controlling the abundance of the HR …
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Design and Synthesis of Pyrimidine Based Fused Heterocyclics in the Potential Treatment of Cancer and Opportunistic Infection
… are two significant limitations in cancer chemotherapy. Microtubule targeting agents (MTAs) are a structurally diverse set of compounds that disrupt microtubule dynamics and exert their anticancer effect. Combination chemotherapy with antiangiogenic agents and microtubule targeting agents …
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Investigating lipid metabolism and gene expression in High Grade Serous Ovarian Cancer (HGSOC) disease progression and chemoresistance
… – tumour debulking surgery and platinum/taxane combination chemotherapy – patients frequently succumb to recurrent disease which is often resistant to chemotherapy. A key stage in HGSOC metastasis is the detachment of cells from the primary tumour, which requires metastatic cells to overcome …
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Investigating a novel small molecule inhibitor of nuclear import as an anti-cancer approach
… including their use as monotherapies and in combination with current chemotherapeutic agents for improved anti-cancer treatment outcome. Recently, research in our own laboratory and others have reported elevated expression of the nuclear transporter Kpnβ1 in multiple cancers. Using the …
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Immune parameters as predictors of response to maintenance therapy in low grade non-Hodgkin's lymphoma patients
… aggressive. Most LG-NHL patients respond well to chemotherapy, but are rarely cured, making death from LG-NHL virtually inevitable. In this study on LG-NHL patients, all patients received combination chemotherapy for 6 weeks, which consisted of cyclophosphamide, oncovin (vincristine) and …
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GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE: A NEW MOLECULAR TARGET IN CHEMOTHERAPY
… cells, perhaps in parallel with conventional chemotherapy. Such an alternative strategy could provide prolonged survival with less severe consequences of cytotoxic agents. To be truly effective, a chemotherapeutic drug should exert its action on biochemical targets specific for neoplastic …
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