Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"colorectal carcinogenesis"”.
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The Role of the Rna‐Binding Protein Hur in Colorectal Carcinogenesis
<p>Colorectal cancer is a leading cause of cancer mortality among adults and the risk of developing colon cancer is increased in those individuals suffering from chronic inflammatory syndromes such as inflammatory bowel disease (IBD). Multiple pro-oncogenic and inflammation associated immediate …
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Bile acid nuclear dehydrogenation by Clostridium species and its implication in colorectal carcinogenesis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
… on whether the CBS/H2S axis plays a role in colorectal carcinogenesis. Here, we report CBS expression upregulation begins in premalignant colonic specimens. Additionally, forced upregulation of CBS in an adenoma-like colonic epithelial cell line (NCM356) is sufficient to induce increased …
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Integration of Genome Scale Data for Identifying New Biomarkers in Colon Cancer: Integrated Analysis of Transcriptomics and Epigenomics Data from High Throughput Technologies in Order to Identifying New Biomarkers Genes for Personalised Targeted Therapies for Patients Suffering from Colon Cancer
Colorectal cancer is the third most common cancer and the leading cause of cancer deaths in Western industrialised countries. Despite recent advances in the screening, diagnosis, and treatment of colorectal cancer, an estimated 608,000 people die every year due to colon cancer. Our current …
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Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
Colorectal cancer is the second leading cause of cancer related deaths in the United States. Approximately 80% of all colon cancers are associated with a mutation in the Adenomatous polyposis coli (APC) tumor suppressor gene. We study the intracellular functions of normal APC and how loss of APC …
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A possible mechanistic role for microorganisms in the genesis of colorectal cancer.
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. An estimated over 140,000 people will be diagnosed with CRC and over 50,000 people will die in 2013. CRC tumors develop from a polyp but the initial cause of the chromosomal instability and mutations …
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Investigating the role of NEIL3 in colorectal cancer resistance to oxaliplatin
Colorectal cancer (CRC) is the third most common type of cancer and accounts for 8 % of cancer related deaths worldwide. While the likelihood of colorectal carcinogenesis increases with age, genetics and lifestyle are major predisposing factors. Treatment can be curative and promises a 39 – 65% …
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Functional Characterization of Bacterial Strains Enriched in Colon Adenomas and Their Impact on Colonic Epithelial Cells
Colorectal cancer (CRC) is one of the most common malignancies worldwide and a leading cause of cancer-related mortality. It arises from the progressive accumulation of genetic and epigenetic alterations in the epithelial cells lining the colon or rectum, often evolving from precancerous lesions …
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The histopathology and immunohistochemical expression of cell cycle regulators and mismatch repair gene proteins in colorectal carcinoma : a comparative study
Introduction: It has been reported that HNPCC colorectal carcinomas demonstrate a better prognosis compared to sporadic carcinoma, however the exact mechanism for this is still uncertain. It is possible that tumour morphology, location and cell cycle markers may be indicators of the underlying …
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Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer
Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. Accumulating epidemiological evidence suggests …
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Selenoprotein P in der kolorektalen Karzinogenese
DNA-Schädigungen durch Sauerstoff-Radikale werden als bedeutende pathogene Faktoren der kolorektalen Karzinogenese angesehen. Als ein antioxidativer Schutzmechanismus im Gastrointestinaltrakt wird u. a. das Selenoprotein P vermutet, dessen mRNA-Expression in Kolonadenomen im Vergleich zu …
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Efecto de la quimioterapia antineoplásica en pacientes con cáncer colorrectal sobre biomarcadores del estrés oxidativo y del estado redox plasmático
El estrés oxidativo, está implicado en diversos procesos fisiopatológicos como el cáncer. Su implicación se debe a alteraciones en el estado redox celular y a un incremento en el daño oxidativo que conllevan alteraciones en el ciclo celular y condicionan la eficacia a la quimioterapia. Se ha …