Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"colorectal cancer patients"”.
-
Inflammatory Biomarkers, Genetics, and Survival among Colorectal Cancer Patients
… inflammation significantly increases the risk of colorectal cancer (CRC) through inflammation-mediated mechanisms. Current evidence regarding the connection between circulating inflammatory biomarkers and CRC prognosis is limited to C-reactive protein (CRP) and interleukin (IL)-6. However, other …
-
Privacy Issues in Young Onset Colorectal Cancer Patients and Survivors
The occurrence of colorectal cancer among those over the age of 50 is decreasing; conversely, the rate of diagnosis for those under 50 years old is increasing. While medical researchers scramble to identify the cause for this increase, young onset colorectal cancer (YOCC) patients and survivors are …
-
Transcriptome-wide association analysis of survival in colorectal cancer patients
Colorectal Cancer (CRC) is the second leading cause of cancer deaths globally. Whilst tumour stage, lymph node status and the presence/absence of distant metastases at presentation are strongly associated with survival outcome, prediction of survival for individual patients is very imprecise. This …
-
Analyzing Extracellular Vesicles for Disease Monitoring in Metastatic Colorectal Cancer Patients
<p>Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. Metastases are the main cause of cancer-related death, and the most frequent metastatic sites in patients with CRCs are liver and lung. To confirm the diagnosis of metastatic CRC (mCRCs) and to classify …
-
Prognostic role of tumour associated trypsin inhibitor in colorectal cancer patients
Colorectal cancer (CRC) is one of the most common forms of human cancer worldwide with approximately 1 million new cases detected every year. CEA is currently the only accepted CRC marker incorporated into clinical practice, where it is used for early detection of metastasis in follow-up of …
-
Quantifying under-treatment in older adult breast, lung and colorectal cancer patients
Background:Lower treatment rates in older patients with cancer exist but may reflect contraindications of advanced disease, comorbidities and frailty. This thesis aimed to firstly review the evidence for under-treatment (UT), secondly to assess the potential for UT using patient-level cancer …
-
Telomerase : a tumor marker in the peripheral blood of colorectal cancer patients
Colorectal cancer (CRC) recurrence after curable resection is still high. This fact strongly suggests that the dissemination of circulating tumour cells (CTC) occurs early in the disease process. The first clinical results obtained suggest that CTC detection and enumeration can be used to estimate …
-
TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS
Patients with IBD have an elevated risk of developing CAC. IL-22, a cytokine involved in epithelial cell proliferation and survival, is also linked to tumor formation. It is secreted by various immune cells, including tissue-resident iNKT cells. In IBD, iNKT cells exhibit either pro-inflammatory or …
-
Mutational analysis of the DNA mismatch repair genes, hMLH1 and hMSH2, in South African colorectal cancer patients
Colorectal cancer (CRC) is one of the most common forms of neoplasia in Western populations but is uncommon in sub-Saharan Africa. In developing countries such as South Africa, differences in lifestyles and environment exist between the various population groups. These differences and the diverse …
-
LncRNA and circRNA expression profiles in tissues and serum exosomes of colorectal cancer patients and cell lines
… tissues (NATs), and in serum exosomes of 20 CRC patients compared to 20 healthy individuals. We identified 8 ncRNAs (CCAT1, CCAT2, CDR1AS, HOTAIR, MALAT1, TUG1, UCA1 and ZEB2AS1) differentially expressed (DE) in tissues and 3 ncRNAs (circ16, TUG1 and UCA1) DE in serum exosomes. Through gene …
-
KRAS Codon 12 and Codon 13 Mutations in Relation to Overall Survival among Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
… exon 2 are frequently occurring mutations in colorectal cancer (CRC). However, the existing published data on the association of KRAS codon 12 and codon 13 mutations on the survival of CRC patients remains inconclusive. To address this, we conducted a systematic PubMed search and …
-
The effect of iron supplementation and tumour location on the mucosal microbiological and immunological environment in colorectal cancer patients with iron deficiency anaemia
Iron deficiency is a common complication of colorectal cancer, being present in ~60% of patients and often leading to the manifestation of anaemia. Preoperative anaemia in colorectal cancer patients is associated with inferior clinical outcomes, hence this leads to the requirement of iron …
-
Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer
… However, as the universally expressed protein in cancer cells, its function beyond pyroptosis, the pyroptotic function and pyroptosis-independent function of GSDMD in cancer cells have been poorly characterized. In my dissertation, I found GSDMD nuclear translocation and the apoptotic role of …
-
An investigation into the factors associated with psychological adjustment in men and women who have undergone surgery for colorectal cancer
Colorectal cancer is a major health problem for both men and women today. It is also lone of several site-specific cancers that patients are likely to survive beyondfive years of diagnosis. The majority of patients show good psychological adjustment following the diagnosis and treatment of …
-
Assessing the Mutational Landscape of BRAF- and KRAS-Wild Type Colorectal Cancer
Colorectal cancer is one of the most deadly cancers and is the second leading cause of death in the United States. As incidence of colorectal cancer is higher among developed countries, research continues in hopes to make marked advancements in the way cancer is treated. A number of targeted …
-
Methylation of Egfr By Arginine Methyltransferase Prmt1 Enhances Egfr Signaling and Cetuximab Resistance
… treatment and poorer overall survival in colorectal cancer patients. These data suggest that R198/R200 methylation plays important role in regulating EGFR functionality and resistance to cetuximab treatment.</p>
-
Immune Landscape of early liver metastatic lesions in a Novel Immunocompetent Murine Colorectal Cancer Metastasis Model
<p>Colorectal cancer minimal residual disease (MRD) represents a major clinical problem for colorectal cancer patients, with failure rates of surgery and adjuvant chemotherapy between 5% to 40% depending on stage of disease. In our study, we simulated MRD using genetically engineered organoids with …
-
Evaluation of SELDI-TOF MS as a tool in colorectal cancer screening
… biomarker discovery in the stool and serum of colorectal cancer patients. <br/><br/>Materials and Methods: <br/>1.Initially a technique of analysis was developed and optimised using tumour samples and matched normal mucosa, obtained from the Tayside Tissue Bank. These samples were then analysed …
-
Working models of attachment and health threats: Distress, appraisal, coping and health-related behaviours in colorectal cancer.
… and coping were studied in 71 male and female colorectal cancer patients undergoing adjuvant treatment. Health-related behaviours were chosen as behavioural outcomes. Although measurement and design issues did not permit a complete test of the model, the results suggested that working models of …
-
Application of fuzzy linear regression models for predicting tumor size of colorectal cancer in Malaysia's Hospital
… parameter (Zolfaghari). A case study in colorectal cancer (CRC) data at the general hospital in Kuala Lumpur was carried out using the five models as mention above. Secondary data of 180 colorectal cancer patients who received treatment in general hospital were recorded by nurses and …
Page 1 of 2