Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"colony stimulating factor 1 receptor (CSF1R)"”.
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Sialylation as a mechanism for preferential Ligand binding in CFS1R
… is largely controlled by signaling through colony stimulating factor 1 receptor (CSF1R). Notably, this receptor can be activated by two non-homologous ligands, colony stimulating factor 1 (CSF1) and interleukin- 34 (IL-34). These two ligands are differentially required for macrophage …
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Identifying the role of microglia in mediating ASD-relevant phenotypes in the adult brain
… immune cells, requires signalling via the colony stimulating factor 1 receptor (CSF1R). The Fms intronic regulatory element (FIRE), a highly conserved super enhancer found in the second intron of Csf1r, is also required for the development of microglia. Autism spectrum disorder (ASD) is a …
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Microglia regulate myelin growth and integrity in the central nervous system white matter
… following loss-of-function of the pro-survival colony stimulating factor 1 receptor (CSF1R). As this approach also targets other CNS macrophages which may contribute to these processes, I sought to investigate the specific roles of microglia in regulating myelin health. To achieve this, I …
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Investigation of inflammatory and oxidative stress mechanisms in the disruption of white matter structure and function following chronic cerebral hypoperfusion
… the second leading form of dementia and vascular factors such as hypertension, diabetes and obesity are associated with an increased risk of developing VCI. White matter alterations are a prominent pathological feature observed in patients with VCI thought to underlie cognitive impairment. …