Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"colonic inflammation"”.
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The Tissue Specific Role of Endosome Associated Protein SNX27 in Colonic Inflammation and Tumorigenesis
… integrity, leakier guts, increased mucosal inflammation, and greater susceptibility towards chemically induced colitis and CRC. While conditional deletion of SNX27 from Paneth cells also increased sensitivity to DSS, SNX27ΔLyz mice contrastingly exhibited less severity towards colitis and …
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Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: Importance of peroxisome proliferator-activated receptor γ expression
… of inflammatory responses. Since intestinal inflammation is a driving force in the development of colon cancer, in the present study, we investigated the suppression of dextran sodium sulfate (DSS)-induced colitis by dietary sphingomyelin in mice that lack functional peroxisome …
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The effects of treadmill and voluntary wheel training on morbidity and inflammation during ulcerative colitis in mice
… therapies, aimed to decrease colon inflammation, can attenuate symptoms of UC but their efficacy is not complete and their side effects can be debilitating. Preliminary studies have shown that there is a positive correlation between high levels of physical activity, reduced …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… tuft cells and enteroendocrine cells (EECs), in colonic inflammation, revealing novel cellular and molecular dynamics. The initial study utilized IEC-specific Hnrnp I knockout mice to demonstrate significant upregulation of pro-inflammatory cytokines such as Il1β, Cxcl1, and Ccl2. This animal …
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Testing the Anti-Inflammatory Effects of Dietary Phytochemicals in Intestinal Inflammation Models
… immune-mediated chronic disease characterized by colonic inflammation, ulcers and erosion. Medications benefit 50% UC patients and have serious adverse effects. Therefore, safe and efficient molecules are needed as stan-alone drugs or in combination with available treatments to increase therapy …
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Effects of potato fiber and soluble corn fiber on the fecal microbiome of dogs with implications to inflammation
… innate immune cell type at the site of inflammation. Therefore, this suggests that fermentation of PF to produce SCFA may be a driving force in controlling leukocyte recruitment to the site of inflammation. As a potential mechanism linking SCFA concentrations and leukocyte recruitment, …
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Molecular Mechanisms of American Ginseng For the Prevention and Treatment of Colitis and Colon Cancer Associated With Colitis
… immune response with repeated episodes of colonic inflammation. While not everyone with colitis will develop colon cancer, risk increases when length of disease exceeds 10 years, on the order of 0.5-1.0% per year. Conventional treatment of colitis can reduce periods of active disease and …
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Influence of intestinal inflammation on bacterial protein expression in monoassociated mice
… proliferation and it exact role in intestinal inflammation are unknown. Aim of this PhD-project was to identify E. coli proteins involved in E. coli’s adaptation to the inflammatory conditions in the gut and to investigate whether these factors affect the host. Furthermore, the molecular basis …