Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"colon tumour"”.
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Integration of Genome Scale Data for Identifying New Biomarkers in Colon Cancer: Integrated Analysis of Transcriptomics and Epigenomics Data from High Throughput Technologies in Order to Identifying New Biomarkers Genes for Personalised Targeted Therapies for Patients Suffering from Colon Cancer
… estimated 608,000 people die every year due to colon cancer. Our current knowledge of colorectal carcinogenesis indicates a multifactorial and multi-step process that involves various genetic alterations and several biological pathways. The identification of molecular markers with early …
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Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor
Background and Aim: During carcinogenesis, tumours develop multiple mechanisms to evade the immune system and suppress the anti-tumour immune response. Upregulation of Fas Ligand (FasL/CD95L) expression may represent one such mechanism. FasL is a member of the tumour necrosis factor superfamily …
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Candidate tumour markers and potential therapeutic targets in colorectal cancer.
Aim: To identify candidate tumour-specific molecular markers for the detection of disseminated tumour cells in peripheral blood and intra-peritoneal lavage samples from patients undergoing surgical resection for CRC and as potential therapeutic targets. Results: cDNA microarray screening identified …
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Studies Towards the Total Synthesis of Patellazole B
… cytotoxicity against the HCT 116 human colon tumour cells. To date however, their full 3D stereostructure have yet to be elucidated, which has hindered their development as potential drugs, and hampered full investigation into their biological mechanism of action and has deterred total …
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Analysis of the functions of phosphoprotein phosphatase 1 catalytic subunits during cell division
… PP1 phosphatases and ultimately generated human colon tumour 116 (HCT116) cell lines containing endogenously tagged PP1β and PP1γ and supervised the generation of a PP1α cell line. I found that degradation of PP1β in a late stage of cell division seems to be affecting processes required for the …
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Comparative Morphological and Immunohistochemical Analysis of Benign and Malignant Epithelial Colon Tumors // Сравнителен морфологичен и имунохистохимичен анализ на бенигнени и малигнени епителни тумори на дебелото черво
Целта е да се проучи имунохистохимичната експресия на протеини APC, p53, SMAD4, MSH2 и BRAF при доброкачествени и злокачествени епителни тумори на дебелото черво във връзка с клинико-морфологичните показатели и ролята им в туморната инициация и прогресия. Получихме следните резултати: с редуциране …