Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"colon carcinogenesis"”.
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Grape Seed Extract as an Adjunct for Modulating Colon Carcinogenesis
Colon cancer is one of the leading causes of cancer deaths in the United States and increasing in incidence globally. Grape seed extract (GSE) is a nutritional supplement with claims as a chemopreventive compound. Preliminary experimental data suggests that dietary GSE may be protective against …
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Soybean lunasin mediates colon carcinogenesis by inducing apoptosis and preventing outgrowth of metastasis
… of this research was to evaluate the anti-colon cancer potential of lunasin isolated from defatted soybean flour using in vitro and in vivo models of CRC. Lunasin was isolated from defatted soybean flour by a combination of different chromatographic and ultrafiltration techniques. The …
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Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase β Haploinsufficient Mice
… plays in the development and progression of colon cancer when dietary folate is deficient. Both cellular folate restriction and BER deficiencies have been shown to result in the accumulation of endogenous damage and lesions that could eventually develop into carcinogenesis. In this study, a …
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The Effects of Time-Restricted Feeding on Early Phases of Liver and Colon Carcinogenesis
The influence of dietary factors on carcinogenesis, particularly the role of high-fat diets, is well-documented, with such diets contributing to altered lipid metabolism, the development of metabolic stress, and chronic inflammation. Given the growing interest in time-restricted feeding (TRF) as a …
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The mechanism of action of the anticancer effects of selenomethionine on colon cancer
… the incidence and mortality rate of lung, colon, and prostate cancers. Another organic selenium derivative found in the selenized yeast is Se-methylselenocysteine. However, the mechanism of action of the anti-cancer effects of these selenium compounds has yet to be identified. To evaluate …
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Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… are involved in the protective effects against colon carcinogenesis is not clearly understood. The objective of this study was to evaluate the dietary prevention of colon carcinogenesis by identifying novel constituents in yerba mate. The first aim was to investigate the potential …
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Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
… of H2S are selectively upregulated in human colon cancer compared to patient matched normal margin mucosa. CBS produced H2S enhances cancer cell bioenergetics, tumor growth, proliferation, and angiogenesis. This dissertation focuses on whether the CBS/H2S axis plays a role in colorectal …
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Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor
Background and Aim: During carcinogenesis, tumours develop multiple mechanisms to evade the immune system and suppress the anti-tumour immune response. Upregulation of Fas Ligand (FasL/CD95L) expression may represent one such mechanism. FasL is a member of the tumour necrosis factor superfamily …
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THE ROLE OF THE RNA-BINDING PROTEIN TRISTETRAPROLIN IN CERVICAL AND COLORECTAL CANCERS
… of TTP is observed during early stages of human colon carcinogenesis and TTP expression in colon cancer cell model dramatically inhibits cell growth and tumorigenecity. We show that the anti-tumor effects of TTP expression in colon cancer cells are, at least in part, a result of delayed cell …
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The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)
… small subset of replication-competent cells, in colon carcinogenesis. Although the role of inflammatory lipid-mediators in CRC progression is well known, their role in the promotion of cancer-initiating cells remains to be elucidated. For this thesis, we investigated the role of eicosanoids – …
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Growth Factors Up-Regulate Epithelial Stem Cells: Treatment Strategies for Colorectal Cancers
… elevated progastrins (PG) increase the risk of colon carcinogenesis, however mechnaims involved remain ill-defined. Recently, cell-surface AnnexinA2 (CS-ANXA2) was discovered as a non-conventional receptor for progastrin. Therefore, the first goal was to examine whether ANXA2 expression is …
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ENZYMOLOGY AND MOLECULAR BIOLOGY OF BILE ACID 7alpha- AND 7beta- DEHYDROXYLATION BY THE INTESTINAL BACTERIA CLOSTRIDIUM SCINDENS AND CLOSTRIDIUM HYLEMONAE
… both a strong selective pressure for potential colonizers, aswell as substrates for microbial metabolism. Indeed, microbes have evolved enzymes to deconjugate bile salts, epimerize bile acid hydroxyl groups, and 7alpha-dehydroxylateprimary bile acids. The products of microbial …
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Epigenetic modifications on WNT genes by dietary genistein during colon cancer development
… development. Abnormal epigenetic events lead to carcinogenesis. Dietary factors have the ability to alter the epigenetic structure of gene and greatly contribute to the risk of colon cancer development. Epidemiological studies have shown that compared to the US, East Asia has a much lower …
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MiRNA-Mediated Regulation of Colorectal Tumorigenesis
… in cancer. MiRNA expression is dysregulated in colon cancer and these changes in miRNA expression patterns account for mis-regulation of its target mRNAs, many of which control cancer-associated pathways. Secondly, disease associated single nucleotide polymorphisms (SNPs) located in the miRNA …
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Die Glutathionperoxidase 2 : physiologische Funktion und Rolle in der Azoxymethan-induzierten Colonkanzerogenese
… In Kryptengrundepithelzellen aus dem Colon selenarmer GPx2 KO-Mäuse wurde eine erhöhte Caspase 3/7-Aktivität im Vergleich zum Wildtyp (WT) festgestellt. Zudem wiesen diese Zellen eine erhöhte Suszeptibilität für oxidativen Stress auf. Die GPx2 gewährleistet also den Schutz der …
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Sulforaphan und Selen : Einfluss auf Phase II Enzyme und Selenoproteine sowie deren Effekt auf die entzündungsvermittelte Dickdarmkanzerogenese
… während der entzündungsverstärkten Colonkanzerogenese im Mausmodell. Das hinsichtlich seiner Wirksamkeit mit aus GRA hydrolysiertem SFN zunächst als vergleichbar befundene synthetische SFN wurde für die Untersuchung im AOM/DSS-induzierten Colontumormodell gewählt und in Kombination …
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CALCIUM SENSING RECEPTOR FUNCTION IN COLON: A ROBUST PROMOTER OF DIFFERENTIATION AND TUMOR SUPPRESSOR
… of calcium sensing receptor (CaSR) in the human colonic crypt epithelium is linked to cellular differentiation while its lack of expression is associated with undifferentiated and invasive colon carcinoma. Recent studies show that CaSR suppresses the malignant phenotype through a variety of …