Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 266 for “"colon cancer"”.
-
Colon Cancer Survivorship Experiences
… activity behaviors, in a sample of colorectal cancer survivors who are at high risk of developing a second colorectal cancer. Participants, recruited from Georgetown University's Lombardi Comprehensive Cancer Center, are colorectal cancer survivors from families at high or confirmed risk of …
-
Colon Cancer Initiation and Progression
Landmark cancer genome resequencing efforts are leading to the identification of mutated genes in many types of cancer.The extreme diversity of mutations being detected presents significant challenges to subdivide causal from coincidental mutations in order to elucidate how disrupted regulatory …
-
The Role of SOX2 in Colon Cancer Progression
… SOX2 is amplified in various types of epithelial cancers and its high its expression correlates with poor prognosis and decreased patient survival. Aberrant Wnt signaling drives the colo-rectal carcinogenic process and is a major determinant of the disease outcome. This study demonstrates that …
-
Microtubule Organisation in Normal and Colon Cancer Cells
… diseases" such"as" cancer." "Microtubule" rearrangements" are"driven"by"their" inherent" dynamics,"which" are" regulated"by"+TIP"proteins." "This"project" aims" to"examine" the" mechanisms" behind" apicoNbasal" array" formation," and" how" they" may" be" compromised" …
-
Genistein suppresses colon cancer metastasis through epigenetic regulations
Colorectal cancer (CRC) is the third most common cancer in the United States. Approximately 90% of colon cancer deaths arise from cancer metastasis, the process by which primary tumors invade into and start to proliferate in a distant new site. Dietary factors are closely associated with …
-
Targeting the tight junction : immunotherapy of colon cancer
A33 is a cell surface glycoprotein of colon epithelium with a long clinical history as a target in antibody-based cancer therapy. Despite being present in normal colon, radio-labeled antibodies against A33 are selectively retained by tumors at long time points. Accordingly, we have studied the …
-
Construction of a mouse model of colon cancer
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
-
Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… and metastasis of tumors involve not only cancer cells, but also the tumor microenvironment, which consists of immune or inflammatory cells, fibroblasts, endothelial cells, and extracellular matrix components (ECM). Fibroblasts are ubiquitous stromal cells that can influence other …
-
Role of Retinol in Colon Cancer Invasion and Metastasis
No abstract prepared.
-
The microbiota and colon cancer risk: cause or consequence?
Background: Colorectal cancer (CRC) has a complex aetiology involving both genetic and environmental factors. Recently, attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut microbiota is altered in CRC and certain microbial patterns are associated …
-
Effect of Soyasaponin Fractions on Human Colon Cancer Cells
… B, as anticarcinogenic agents on the human colon adenocarcinoma cell line Caco-2. Experiments were conducted to determine the effects of purified soyasaponins on cell proliferation, Protein Kinase C (PKC) activity, and cell morphology in cultures of Caco-2 cells. Treatment of cells with …
-
Inflammation enhanced colon cancer & natural anti-cancer plant compounds
… associated with an increased risk for colorectal cancer through mechanisms that are not well understood. Isothiocyanates, which are the bioactive components in broccoli and other cruciferous vegetables, have been shown to suppress COX-2 and IL-6 production from inflammation. The polyacetylene …
-
Role of ß-catenin and Leukotriene in Colon Cancer Progression
Abstract Colorectal cancer is the third most common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of …
-
Loperamide enhances bortezomib-mediated cell death in colon cancer cells
… and antibodies 8 B. Cell culture of various cancer cell lines and normal cells 8 C. Measurement of cell viability 9 D. Western blotting 9 E. Immunocytochemistry 10 F. Establishment of the stable cell lines in the fluorescence specifically endoplasmic reticulum 10 G. Measurement of …
-
PTEN loss induces epithelial-mesenchymal transition in human colon cancer cells
… event in the invasion and metastasis of many cancers, including colorectal cancer. Chronic inflammation is an inducer of several cancers and inflammatory cytokines have been implicated in tumor invasion. Materials and Methods: Human colon cancer cell lines HCT116 and SW480 were transfected …
-
The Role of Streptococcus Gallolyticus Subspecies Gallolyticus In Colon Cancer Development
<p>Colorectal cancer (CRC) is the third most common cancer in men and women and is also the third most common cause of cancer death. A large body of evidence points towards the possibility that bacteria can have a significant impact on the development of cancer. It has been suggested that …
-
Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
<p>Previous studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation …
-
Risk, colon cancer & physical activity: a qualitative exploration in older adults
… that physical activity (PA) reduces risk of colon cancer (CC) and may improve survival after cancer, although few older adults achieve recommended PA guidelines. Numerous barriers to participation exist, though few studies focus on socio-cultural influences. This study explores barriers …
-
Effects of modified bioactive pectins on colon cancer cells in vitro
… pH, heat or enzymes, has been shown to have anti-cancer activity in several cancer cell lines. The galactan chains of MP are postulated to be essential for bioactivity due to their ability to bind and inhibit the pro-metastatic protein galectin-3 (Gal3) on cancer cells. However, the structural …
Page 1 of 14