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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"collision-induced dissociation"”.
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Reducing interferences in glow discharge spectroscopies using transient operation and collision -induced dissociation
… signals. The second method is to employ collision-induced dissociation in a quadrupole ion trap in order to reduce molecular interferences in atomic mass spectrometry.;Optical and mass spectrometric studies are described in which the spatio-temporal evolution of the pulsed glow discharge …
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Experimental And Theoretical Studies Of Binding Interactions In Divalent Transition Metal Cation-N-Donor Ligand Complexes: Structures, Sequential Bond Dissociation Energies, Mechanisms And Energetics Of Collision-Induced Dissociation
… experimental studies make use of energy-resolved collision-induced dissociation (CID) techniques that are carried out in a custom-built guided ion beam tandem mass spectrometer (GIBMS) to probe the structures, energetics, and fragmentation behavior of the complexes of interest. Electronic …
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Noncovalent Interactions Between Alkali Metal Cation And Aza/thia-Crown Macrocycles: Mass Spectrometric Techniques And Theoretical Studies
… alkali metal cations. Infrared multiple photon dissociation (IRMPD) action spectroscopy and energy-resolved collision-induced dissociation (CID) techniques were used in conjunction with theoretical electronic structure calculations to characterize the structures, binding interactions, and …
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Mass Spectrometry Studies on the Dissociation of Metal-Adducted Oligosaccharides, Glycopeptides, and Fatty Acids
… its efficacy is hindered by poor ionization and dissociation of these biomolecules. Consequently, derivatization is commonly employed to enhance ionization and dissociation efficiency.This dissertation focuses on exploring the use of in-source decay (ISD) and high-energy collision-induced …
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Mass spectrometric characterization of remotely charged amino acids and peptides
… nitrene anion in the para position.</p> <p>The dissociation pathways of gas-phase amino acids with a canonical (nonzwitterionic) α-amino acid moiety are studied by using mass spectrometry. Investigation of the canonical amino acid moiety is possible because the ionized amino acid has a charge …
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Aspects of the chemistry of 1,4-naphthoquinones. An investigation of nucleophilic substitution reactions of alkylamines and hydroxyalyklamines on 1,4 napthoquinones and the role of solvent on the position of substitution.
… were also synthesised. The collision-induced dissociation mass spectra of protonated hydroxyalkylamino-1,4- naphthoquinones showed fragmentation patterns which were dependent on the nature and length of the side chain and the presence and nature of the adjacent group on the …
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Modeling Peptide-binding Interactions and Polymer-binding Interactions and their Role in Mass Spectrometry
As a first project, collision-induced dissociation experiments were carried out using electrospray ionisation mass spectrometry on gas phase complexes involving different poly(methylmetacrylate) oligomers with three amino acids: glycine, leucine, and phenylalanine. After acquiring breakdown …
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Ion Mobility and Gas-Phase Covalent Labeling Study of the Structure and Reactivity of Gaseous Ubiquitin Ions Electrosprayed from Aqueous and Denaturing Solutions
… with selective covalent structural probes. Collision cross-section (CCS) distributions were measured prior to ion/ion reactions to ensure the ubiquitin ions were not unfolded when they were introduced to the gas phase. Ubiquitin ions were electrosprayed from aqueous and methanolic solutions …
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Gas-phase Ion Chemistry of Hydroxy and Amino-substituted Interstellar Polycyclic Aromatic Hydrocarbons and Protonated Polycyclic Aromatic Hydrocarbons
… with a magnetic sector tandem mass spectrometer. Collision-induced dissociation (CID) experiments were used in conjunction with MIKES experiments to determine ion structure. The ten molecules studied were: 1-naphthol, 2-naphthol, 1-naphthylamine, 2-naphthylamine, 1-aminoanthracene, …
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Assessment of nutraceutical attributes of selected wild edible fruit plants used by Vhavenda people of the Thulamela Local Municipality
… this study the UHPLC-qTOF-MS/MS-based in source collision induced dissociation method was utilized to generate fragmentation data to assist in the differentiation of closely related isomers. Wild edible fruit plants have been used for centuries in traditional medicine and for nutritional …
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Applications of Mass Spectrometry to Analysis of Prodiginines, Bioactivated Methylenedianiline Intermediates, and Hypoxia Induced Changes in the Zebrafish Skeletal Muscle Proteome
… fragment ions that dominate the low-energy collision induced dissociation (CID) mass spectra of prodiginine compounds. Structures of the fragment ions are proposed and explanations are given to rationalize the observed competition between the formation of even-electron ions and radical ions. …
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Understanding MS/MS fragmentation pathways of small molecular weight molecules
Fragmentation of molecules by collision-induced dissociation (CID) is not well-understood, making interpretation of MS/MS spectra difficult and limiting the effectiveness of software tools intended to aid mass spectral interpretation. An approach is required which is tailored to each individual …
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High-throughput analysis of emerging and historical pollutants in biological matrices.
… the method sensitivity by optimizing resonant collision induced dissociation energy through ion-trap mass analyzer. The nationwide PPCP study found that the proximity of sampling locations to the upstream wastewater treatment plant discharging point and mean annual flow at the sampling …
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Structural analysis of cytokine signaling modulators
… ligands were absent from Mgat 5 null cells. Collision Induced Dissociation in a MALDI-IT-TOF instrument was used for N-glycan structural determination. For monitoring the alterations in N-glycosylation, null and wild type Mgat 5 cells were grown in medium supplemented with increasing GlcNAc …
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Method development for the comprehensive analysis of post translational modifications by mass spectometry
… fragmenting the modified protein or peptide by collision induced dissociation (CID) within the mass spectrometer, and then screening for the characteristic neutral fragment or fragment ion (marker ion), which is particular to the modification in question. Unfortunately, there are two major …
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The Influence of Changes In theMolecular Structure of N-Acylhomoserine Lactones On the Complexation and Dna-Binding of Luxr Protein
… structural information acquired via in-source collision-induced dissociation. Results indicated that concurrent oxidation and nitration occurred on the acyl side chain of C6-HSL and its open-ring form. The structures of eleven hydroxyl radical oxidation products were postulated. Furthermore, …
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Mass spectrometric characterization of peptide radical ions and implication for radical chemistry
… are investigated via MS approaches including collision-induced dissociation (CID), H/D exchange, and ion/molecule reactions. Theoretical calculations have also been utilized to further explain the experimental phenomena. Different from carbon-centered radical species, sulfinyl radicals exhibit …
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Mass Spectrometric Analysis of Thiol Proteins/Peptides Following Selenamide Derivatization And Electrolytic Reduction of Disulfide Bonds
… be significantly improved for electron-capture dissociation (ECD) and collision-induced dissociation (CID) analysis. Furthermore, the online coupling of LC with liquid sample DESI-MS was established, which allows a wide range of elution flow rates, online derivatization viareactive DESI to solve …
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Mass spectrometry studies of immunoglobulins
… and various tandem MS techniques including collision-induced dissociation (CID), higher-energy collisional dissociation (HCD) and electron transfer dissociation (ECD). PTMs observed include truncations, mono-/di-chlorination of the tyrosine residues and a nitrile group formed from the …
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Development of ion mobility mass spectrometry deconvolution strategies for use in data-independent acquisition proteomics.
… Chemometric deconvolution and post-IM/collision-induced dissociation (postIM/CID) MS were used to extract "pure component" IM profiles and construct CID mass spectra of IM-MS unresolved species. Collision-energy resolved and broadband IM-MS deconvolution strategies were developed and …
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