Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"collective migration"”.
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Collective migration of epithelial sheets
… ubiquity and relevance, the basic origin of the collective motion of sheets has eluded a clear and quantitative interpretation in physical terms, prohibited by the lack of understanding of the relationship between motility, cell-cell contact, and their mediation by the mechanical properties of …
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An Interacting Particle System for Collective Migration
Kollektive Migration und Schwarmverhalten sind Beispiele für Selbstorganisation und können in verschiedenen biologischen Systemen beobachtet werden, beispielsweise in Vogel-und Fischschwärmen oder Bakterienpopulationen. Im Zentrum dieser Arbeit steht ein räumlich diskretes und zeitlich stetiges …
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Continuum Models of Collective Migration in Living Tissues
… investigates the physical mechanics of collective cell migration in monolayers of epithelial cells. Coordinated cell motion underlies a number of biological processes, including wound healing, morphogenesis and cancer metastasis, and is controlled by the interplay of single cell …
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Directed Cell Migration: From Single Cells to Collectively Moving Cell Groups
… and modeling of directed individual and collective cell migration. At subcellular scale, the migration of cells can be guided via the interaction of the cell cytoskeleton with the surrounding nanotopographic elements. I show that mechanical waves of actin polymerization are involved in …
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Collective Chemotaxis of Retinal Neural Cells from Drosophila Melanogaster in Controlled Microenvironments
… series of highly complicated differentiation and migration process. A main cause of these diseases is abnormal collective migration of neural progenitors hindering the retinogenesis process. However, our grasp of collective migration and signaling molecules, critical to the developing retina, is …
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Impact of Vimentin Intermediate Filaments on 3D Multicellular Collective Behavior
… properties aid in a cell's survival and migration. It forms a hyperelastic network and works synergistically with actin and microtubule to protect against large deformations. Despite vimentin intermediate filaments critical role in many biological processes, there are limited studies on …
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Investigating the mechanisms of cell competition in mammals using in vitro systems
… p53-high and p53-low cells engage in directional migration, with p53-high cells always at the migrating front. As a side-project, I investigated the role of p53 in directional migration, by exploring an established model with a single leader cell and multiple followers. We established a method to …
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HORMONAL AND MECHANICAL CUES ON DYNAMIC CELLULAR PROCESSES IN ENDOMETRIOSIS
… of life. Dysregulated behaviors such as cell migration, invasion, proliferation, and immune escape drive lesion formation. The endometriotic microenvironment contributing to these cell behaviors is complex, with notable components including high local levels of estradiol (E2), a potent …
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Regulation of MINK1 by APC, PKA and MARK3/4 and consequences for epithelial cell biology
… formation, orientation and function and in cell migration. APC, too, has been linked to spindle orientation and MINK1 is phosphorylated during mitosis. Investigating the functional link suggested by these observations, I found that MINK1 overexpression caused spindle misorientation. So far, I was …
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The hybrid epithelial/mesenchymal phenotype and its implications in cancer metastasis
… Transition (MET) that facilitates cells to shed migration and regain adhesion to colonize other organs. While undergoing EMT or MET, cells can adopt a hybrid epithelial/mesenchymal (E/M) phenotype through which they can both adhere and migrate, leading to collective migration as clusters of …
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Studying the role of noise in E. coli chemotaxis
… therein in strains that were selected for faster collective migration through agar. In this work, we attempt to connect changes in relevant molecular constituents of the chemotaxis network, CheR and CheB, to changes in motility and chemotaxis at the individual and population level.
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Forces Generated by Cell Intercalculation Tow Epidermal Sheets in Mammalian Tissue Morphogenesis
… and individual movements—are processes of cell migration. Throughout our lives, cell migration plays a role in the maintenance and regeneration of our tissues, and even in the development and progression of disease. To carry out the complex tasks of development and tissue morphogenesis, cells …
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MECHANOPROPERTIES, HETEROGENEITY AND CELL MIGRATION IN GLIOBLASTOMA
… little is known on how it is reflected on cell migration, mechanoproperties and motility modes. Generally, the tumor cells invade the brain moving on brain vasculature or white matter tracks: Patient-Derived Xenograft (PDX) has been a standard to reproduce them in order to study GBM invasion. …
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The mechanisms underlying mechanical cell competition and leader cell migration in mammalian epithelia
… tight clones through activation of a directed, collective migration in the wild-type population: scribKD are ‘mechanical losers’ and delaminate and die due to an intrinsic hypersensitivity to high cell density. Remarkably, p53 activation is both necessary and sufficient for this mechanical loser …
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Collective Behavior of Drosophila Melanogaster Neural Progenitor and Imaginal Disc Cells within Controlled Microenvironments
… by a structure called the Optic Stalk (OS). Collective migration of neural and retinal progenitor cells (RPCs) from the developing brain lobes (DBL) to the Imaginal Disc (ID), through the OS, is a fundamental part of regenerative strategies in retina. Developmental signals governing retinal …
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Stress Fiber Formation and Migration Are Novel PGR-Dependent Pathways Initiated in the Granulosa Cells of the Ovulating Follicle
… granulosa cell stress fiber function and migration as novel PGR-dependent pathways occurring during ovulation. Two key PGR-regulated genes, Jam3 and vinculin were investigated further to establish a role in oocyte release. Vinculin, a stress fiber protein important for cell-ECM connection …
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Nodal organized cell dynamics for building tissue shapes in vertebrate gastrulation
… tissue shapes form as a result of large-scale collective cell changes. How cell dynamics and mechanics link molecular scale genetic changes to tissue scale developmental outcomes is a major unresolved question in biology. Nodal is a key developmental regulatory gene from the TGF-β family that …
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MECHANO-CHEMICAL FEEDBACK VIA CONTACT PERCOLATION REGULATES PHASE TRANSITION AND TRANSCRIPTIONAL STATE IN HETEROGENEOUS BREAST CANCER
… phase transitions (PTs), that enable collective motility, immune activation, and tumor invasion. We recently demonstrated that RAB5A, an endocytic small GTPase, induces tissue fluidification, promotes BC progression, and triggers an inflammatory gene response via cGAS/STING pathway and …