Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"collapsin response mediator protein"”.
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
… of Navs and/or auxiliary subunits as well as protein-protein interactions as Nav-trafficking mechanisms. Here, I tested if post-translational modifications of a novel Nav1.7-interacting protein, the axonal collapsin response mediator protein 2 (CRMP2) by small ubiquitin-like modifier (SUMO) …
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The characterization of collapsin response mediator protein-1 (CRMP-1) for Arp2/3 dependent actin structures
… cytoskeleton, composed of actin and its binding proteins, drives cell motility, determines cell shape, and is necessary for strong cell-matrix and cell-cell adhesion. Consistent with its critical function in cell physiology, actin assembly is highly regulated. One of the key factors controlling …
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Exploring the effect of genetic calpain disruption on cell migration, invasion, drug sensitivity, and metastasis in triple negative breast cancer
… breast cancer. I also explored the role of collapsin response mediator protein 2, a calpain substrate and microtubule-binding protein, in paclitaxel treatment. I hypothesised that calpain-deficient cells would be less migratory, invasive, and metastatic than wildtype cells and that calpain …
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A Novel Collapsing Response Mediator Protein 2 Binding Domain for Kinesin Light Chain 3
… of sperm flagella. Recently, we have shown that Collapsin Response Mediator Protein 2 is required for ciliogenesis, localizes to the basal body, and can be transported into the primary cilium, however, the involved mechanism is not clear, but was proposed to involve kinesin proteins. KLC3 is the …
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The development of a method to deliver neuroprotective peptides specifically into stroke-affected neurons
… with a sequence cleavable by calpain from the protein Collapsin Response Mediator Protein-3 (CRMP-3). These results suggest that it is possible to concentrate therapeutic agents into stroke-affected neurons, and this may translate into enhanced neuroprotective properties in both in vitro and in …
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The role of semaphorin 3A signaling underlying learning and memory formation in the postnatal mouse brain
… of secreted and membrane-bound guidance cue proteins originally identified in the developing nervous system through their chemorepulsive action at growth cones. Growth cones are actin-rich structures found at the tips of neurites that eventually form synaptic connections, and semaphorins were …