Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"collagen-induced arthritis"”.
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Characterization of Rheumatoid Arthritis-Specific Immune Responses and Evaluation of a Novel Peptide Immunotherapy in the Collagen Induced Arthritis Mouse Model
Rheumatoid arthritis (RA) is an incurable autoimmune disease that predominately affects the joints. RA is characterized by a breakdown of immunological tolerance against citrullinated and homocitrullinated proteins/peptides (CitP and HomoCitP). To study RA, mice with collagen induced arthritis …
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The role of IL-27 and IL-35 in inflammatory diseases
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by chronic inflammation within the synovial tissues in multiple joints leading to progressive, erosive destruction of cartilage and underlying joints. The severity of RA is associated with the overexpression of …
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
Human autoimmune diseases such as reumatoid arthritis (RA) and multiple sclerosis (MS) are believed to develop when self-tolerance mechanisms are failing, with a chronic destructive inflammation as result. To experimentally study autoimmunity, we have used murine models that mimic their human …
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… protective role in another autoimmune disease, collagen-induced arthritis. Unexpectedly, using C57BL/6 and CysC null (CysCKO) mice, I discovered that CysC plays a detrimental role in female but not male EAE mice. This sex dimorphism in the function of CysC could also be observed in immune cell …
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The effect of small molecule analogues of the immunomodulatory helminth product ES-62 on denritic cell responses
… as they significantly down-regulated LPS-induced cytokine production in vitro. ES-62 requires TLR4 and MyD88 to mediate many of its anti-inflammatory effects. However, cytokine inhibition mediated by SMAs 11a, 12b, 11e and 11i is generally intact in TLR4 knock-out (KO) and MyD88 KO bmDCs. …
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The Role of Interferon Gamma in the Regulation of IL-18 Binding Protein and the Development of Autoimmune Arthritis in a Genetically Non-Susceptible Mouse Strain
… etiology of the autoimmune disease rheumatoid arthritis (RA) is unknown, but the role of cytokines, including IFN-g, as effectors of immune cell function has been established by the examination of cytokine production in RA patients and through the use of animal models. C57BL/6 (B6) mice that …
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An Investigation of the Interplay Among CX3CR1, Immune Cells, and Gut Microbiota in Lupus-Associated Arthritis and Renal Disease using the MRL/lpr Mouse
… kidney disease and joint inflammation arthritis, CX3CR1 was found to affect them differently. The absence of CX3CR1 worsened kidney disease but improved arthritis. Different immune cells such as T cells and myeloid cells were observed to correlate with arthritis and/or kidney disease. A …
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Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models
… exhibited susceptibility to spontaneous arthritis disease (SAD), while those of a DBA/1 background were resistant to developing SAD. Our progress on the study of SAD suggested that some of the bone phenotypes, BMD, BV, tibia length, and cortical thickness, were different between wildtype …
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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents
Rheumatoid arthritis (RA) is one of the autoimmune diseases, and is affecting 2.5 million Americans in total. Among the treatment options of RA, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] is the only steroidal drug used clinically for anti-inflammatory and immune diseases. However, long-term use of …
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The effects of ES-62 on DC maturation and effector function
… little evidence of pathology, due to parasite-induced immune modulation. The consensus of opinion, to date, is that such parasites achieve prolonged survival as a result of their active modulation of the host’s immune system by secreted immunomodulatory molecules. Consistent with this, the …
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Characterisation of the anti-inflammatory potential of ES-62 in autoimmune disease
… inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes and multiple sclerosis. Moreover, in the developed world, there has been an alarming increase in these inflammatory diseases, coincident with recent improvements in hygiene; a trend not observed …