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Showing 1 to 9 of 9 for “"collagen triple helix"”.
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Transient collagen triple-helix binding to membrane type 1 matrix metalloproteinase : interaction studies and NMR-guided structural docking
… REQUEST.] MT1-MMP (MMP-14) as pericellular collagenase is critically involved in cancer cell invasion through collagen barriers that it degrades. To better understand the structural and mechanistic details underlying collagenolytic activity of MMP-14, a solution NMR approach is used here to …
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Application of ab initio calculations to collagen and brome mosaic virus
… important interest. We study two such proteins. Collagen contains one such protein, the collagen triple-helix, which forms part of the structural matrix for animals, such as in their bones and teeth. 1JS9 is another protein that is a component of the protein shell of the brome mosaic virus (BMV). …
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I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics
Collagen is one of the most important and abundant proteins in mammals. It consists of three left-handed PPII helixes coiled along a common axis to form a very compact right-handed super helix. The primary structure is shown to be (Gly-Xaa-Yaa)n repeats with high content of prolyl residues at both …
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Design, Structure and Applications of Collagen-Mimetic Peptides
The collagen triple helix is a unique protein fold found in all domains of life where is has diverse roles from imparting structure and strength to tissue, to initiating an immune response. While many factors affecting the structure and stability of the triple helix have previously been elucidated, …
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The role of unfolded states in collagen degradation
Excessive collagen degradation (collagenolysis) has been implicated in a series of diseases such as tumor metastasis, atherosclerosis and arthritis. There are still several unresolved questions about the mechanism of collagenolysis. First, the prototypical structure of the collagen triple helix …
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Design of Collagen-Mimetic Peptides
<p>Collagen is the major component of the extracellular matrix and is involved in a wide range of cellular functions during tissue development and action. At the core of the diverse functions of this versatile protein is its remarkable ability to form supramolecular structures through self-assembly …
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Development of Collagen Mimetic Mini-Fibrils with Tunable Collagenase Susceptibility
<p>Collagen fibrils are the primary molecular scaffold of all connective tissues and provide the essential support for cell migration and differentiation. Collagen fibrils represent one of the most complex molecular hierarchies: three polypeptide chains in Gly-Xaa-Yaa repeating amino acid …
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Damaged Collagen Detection and A Novel Approach to 1,3-Dipolar Cycloaddition Reactivity: Research at the Interface of Chemistry and Biology
Part I Chapter 1. Collagen Mimetic Peptides as a Selective Binder for Damaged Collagen. “Collagen diseases” were first introduced by Klemperer and coworkers in the 1950s. This type of disease can cause fibrinoid degeneration or changes in the collagen fibers that denature the collagen triple helix. …
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Isomerization-Locked Alkene Analogues of Xaa–Pro Dipeptides in the Proteins Collagen and Bora
Collagen is one of the most abundant human proteins. It exists as a right-handed superhelix called the triple helix. The triple helix consists of three left-handed polyproline type II (PPII helices) that intertwine around a common axis. Each PPII helix has the repeating peptide sequence …