Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"collagen matrix"”.
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The use of SurgiSIS, an acellular collagen matrix, in endoscopic urethroplasty
To evaluate small intestinal submucosa (SurgiSIS) as a substitute for skin in endoscopic urethroplasty performed as treatment for inflammatory and iatrogenic stricutres of the male bulbar urethra and in the early treatment of bulbumembranous urethral injuries associated with recent pelvic …
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Investigation of Neutrophil-Like HL-60 Cell Migration in a 3D Collagen Matrix
… to create a concentration gradient inside a collagen gel that contained neutrophil-like (dHL-60) cells. Our experimental setup and computational analysis allowed us to study the cell migration indicators such as percentage and velocity of motile cells in a 3D environment. Evaluating these …
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Healing Following Periodontal Reconstructive Surgery : Surgical Implantation of a Collagen Matrix or Demineralized Freeze-dried Bone Allograft
… surgery including surgical implantation of a collagen matrix or demineralized freeze-dried bone allograft (DFDBA) was evaluated in a preclinical (collagen) and a clinical (DFDB A) study.</p> <p>Contralateral periodontal fenestration defects in 7 beagle dogs were used to evaluate the effect of …
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Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix
… (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed a collagen-GAG scaffold specifically developed for tissue engineering and investigated the effect of this substratum on the formation of lung histotypic structures in vitro. A cell isolation …
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CLINICAL EFFICACY OF XENOGENEIC COLLAGEN MATRIX AS A COMPARATIVE ALTERNATIVE TO FREE GINGIVAL GRAFT IN AUGMENTING KERATINIZED MUCOSA WIDTH AROUND DENTAL IMPLANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
… Clinical studies have demonstrated a xenogeneic collagen matrix (XCM) potential as a means of increasing the width of keratinized tissue around dental implants without the need for an autologous graft and second surgical site (Rokn et al., 2020), improving patient post-surgical experience and …
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Building a Better Scar: Re-engineering Extracellular Matrix Structure in Dermal Scars
… guinea pig trials of αCT1 were examined for collagen matrix structure at 4 weeks (all models), and 2 and 6 weeks (rat and guinea pig models only). Collagen matrix variables examined included local disorganization of the fibers, a variable that is higher in unwounded skin compared to scar …
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Neurales tissue engineering zur Unterstützung anatomischer und funktioneller Wiederherstellung nach akuter experimenteller Rückenmarksläsion der adulten Ratte
… of 1 - 2 mm). A novel, orientated, type I collagen matrix (either seeded or non-seeded with syngeneic olfactory ensheathing cells, OEC) was implanted into the lesion gap and the function of the ipsilateral fore-paw was monitored. At the end-point survival time of 5 months, animals were …
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Metabolic-response assessment of metastatic murine breast cancer in 2D and 3D cultures using intrinsic NADH as a natural biomarker
… response of 4T1 cells in 2D monolayer and 3D collagen matrix cultures to drug treatment using two novel metabolic drugs, namely MD1 and TPPBr. Both 2P-FLIM and complementary time-resolved anisotropy approaches reveal significant differences between metabolic activities of 4T1 cells in 2D and …
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The role of sphingosine kinases and SKAM1 in cutaneous wound healing
… has shown that overexpression of SKAM1 induced collagen matrix contraction, an in vitro model of wound contraction, was mediated by SK1 and the S1P receptors, S1P₁ ̷ ₃. Using a number of classical in vitro models of wound healing, I found that overexpression of SKAM1 in NIH3T3 fibroblasts did …
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RHAMM Alters Vascular Smooth Muscle Cell Constrictive Matrix Remodeling
… affects arterial SMC adhesion, migration and collagen matrix remodeling in vitro as well as constrictive remodeling following artery injury in vivo.
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Development of in vitro Chylomicron Assay Using Caco-2 Cells
… effects of oleic acid, mono-olein, egg lecithin, collagen matrix, and the effect of cell differentiation on CM secretion were then tested. We found that oleic acid, lecithin, and cell differentiation are critical for CM secretion by Caco-2 cells. To further confirm that our optimal condition is, …
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Verfahren zur Herstellung gefriergetrockneter Kollagenschwämme mit definierter Porenstruktur
Collagen sponges are used in many medical application as implant or as biomaterial in the field of tissue engineering. It is commonly assumed that the inner three-dimensional structure of the collagen sponges influences cell behaviour. Until now, this influence could not be investigated …
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Improving the delivery and efficacy of molecular medicine via extracellular matrix modulation : insights from intravital microscopy
The extracellular matrix of tumors is a major barrier to the delivery of molecular medicine. We used fluorescence recovery after photobleaching combined with intravital microscopy to quantitate the transport properties of the tumor interstitium. We found that the presence of fibrillar collagen …
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Development of an experimental system to determine the contribution of titin and collagen to passive stiffness of myocardium
… in intracellular titin and extracellular collagen matrix. Titin is a giant extensible protein, the third filament of striated muscle after actin and myosin, which provides elasticity to passive sarcomeres. The aim of this study is to develop an efficient experimental system that will prove …
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Stiffness of vascular smooth muscle cells from aged primates measured using reconstituted tissue model
… has implicated stiffening of the extracellular collagen matrix with age. The study reported in this thesis focused instead on the potential contribution from stiffening of the vascular smooth muscle cells (VSMCs) with age. VSMCs previously obtained from young and old monkeys (macaca …
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Effects of hypertension and aging on vascular smooth muscle cell contribution to reconstituted aortic tissue stiffness
… to occur due to changes in the extracellular matrix. However, an increase in cell stiffness could also be important. To study the cellular contribution to aortic stiffness, a reconstituted aortic tissue model (composed of vascular smooth muscle cells (VSMCs) in a collagen matrix) was …
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Functions of small leucine-rich repeat proteoglycans in connective tissues
… properties of connective tissues rely heavily on collagen and its use in formation of extracellular networks (matrices) in which cells can live and move. To regulate the process of collagen matrix assembly, the cells secrete small leucine-rich repeat proteoglycans (SLRPs) that bind to collagen and …
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Analyzing Interactions Between Cells And Extracellular Matrix By Atomic Force Microscopy
Interactions of cells with the extracellular matrix (ECM) have important roles in various physiological and pathological processes, including tissue morphogenesis during embryonic development, wound healing and tumor invasion. Although most of the proteins involved in cell-ECM interactions have …
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Modelling Human Glomerulosclerosis in vitro
… This is characterised by excessive extracellular matrix deposition and cell dysfunction leading to disproportionate MC proliferation and POD loss. Animal models of glomerulosclerosis often do not reflect disease pathophysiology and 2D glomerular cell monocultures provide limited insight into a …
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Modulation of the angiogenic potential in collagen matrices by immobilisation of heparin and loading with vascular endothelial growth factor
… decided to incorporate heparin molecules into collagen matrices by covalently cross-linking them to amino functions on the collagen. Physical binding of VEGF to the heparin may then prevent a rapid clearance from the implant, while the release rate may be coupled to the degradation of the …
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