Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"collagen fibril"”.
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DESIGNER COLLAGEN-FIBRIL BIOGRAFT MATERIALS FOR TUNABLE MOLECULAR DELIVERY
One of the biggest challenges in tissue engineering currently is the formation of a functional microvascular network as part of an engineered tissue graft. Despite many advances in tissue engineering methods, the field still awaits biograft designs that enable neovascularization at clinically …
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Scanning Probe Microscopy of Biomaterials and Nanoscale Biomechanics
… was utilized to systematically study individual collagen fibrils and cortical bone samples at the nanoscale with the focus on their mechanical and electromechanical properties. Furthermore, a new nanoneedle-based AFM technique was demonstrated to image soft materials such as membrane of living …
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Predicting Articular Cartilage Constituent Material Properties Following In Vitro Growth Using a Proteoglycan-Collagen Mixture Model
… proteoglycan model was combined with a novel collagen fibril model and a ground substance matrix material to create a polyconvex constitutive finite element model of a<a>rticular </a>cartilage. The true collagen fibril modulus , and the ground substance matrix shear modulus , were varied to …
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Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes
… have suggested that functional variants within collagen encoding genes are associated with several musculoskeletal soft tissue injuries and other exercise-related phenotypes. Specifically variants within the functional COL5A1 3’- untranslated region (UTR) have previously been associated with (1) …
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Crack propagation in bone on the scale of mineralized collagen fibrils: role of polymers with sacrificial bonds and hidden length
… using a simplified model of a mineralized collagen fibril sliding on a polymeric interface with SBHL systems. A 1D coarse-grained nonlinear spring-mass system is used to model the fibril. Rate-and-displacement constitutive equations are used to describe the mechanical properties of the …
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The role of type I collagen heterotrimers and homotrimers in mechanical strength and collagen cleavage
Collagen is a crucial structural protein, formed through a hierarchical assembly of molecules, arranged in collagen fibrils, which constitutes the basis for larger-scale fibers. Normal type I collagen is a heterotrimer triple-helical molecule consisting of two alpha-1 chains and one alpha-2 chain. …
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Multiscale modeling of elastic moduli and strength of bone
… different length scales: nanoscale (mineralized collagen fibril level), sub-microscale (single lamella level), microscale (single osteon and interstitial lamella level in cortical bone and single trabecula level in trabecular bone), and mesoscale (cortical bone level and trabecular bone level). …
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The Role of Mechanical Interactions between Cells and the Extracellular Matrix on Mineralization in a Stem Cell-Seeded Scaffold: a Multi-Scale Approach
… healing rate in difficult-to-heal cases. Cell-collagen gel constructs have been recently used in several studies to promote mineralization. However, the role of mechanical factors to accelerate fracture repair has not been optimized nor is fully understood. The goal of this study was to …
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Nanomechanics and ultrastructural studies of cortical bone : fundamental insights regarding structure-function, mineral-organic force mechanics interactions, and heterogeneity
… interact. Bone is made primarily up of type I collagen, hydroxyapatite mineral, a variety of non-collagenous proteins, and water. A multitechnique experimental and modeling approach methodology was used break down several of the deformation mechanisms that exist in bone at the nanoscale …
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Characterisation of the 3'-UTR of the COL5A1 gene: implication for musculoskeletal soft tissue injuries
COL5A1 encodes the α1 chain of type V collagen, a minor fibrillar collagen that is an important regulator of collagen fibril assembly. A polymorphism (rs12722, C/T) within the 3'-untranslated region (UTR) of COL5A1 is associated with chronic Achilles tendinopathy (TEN) and other soft tissue …
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Characterizing Corneal Biomechanical Properties Using Dynamic Optical Coherence Elastography
… electron microscopy. Corneal thickness and collagen fibril separation computed as the average radial inter-fibrillar distance from the sampled fibril cross-sectional electron micrographs were recorded. b) OCE imaging was performed using phase-sensitive OCT imaging to quantify the tissue …
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Dynamic Changes in Collagen Organization Modulate Cervical Remodeling During Pregnancy and Parturtion: New Insights and the Potential for Improved Clinical Tools to Combat Preterm Birth
… focus of this study was to identify how cervical collagen is reorganized throughout pregnancy to allow the cervix to become compliant for parturition. Beginning early in pregnancy a reduction in cervical collagen cross-links as well as a decline in matricellular proteins contribute to the changing …
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Diffuse Damage Repair Mechanism in Bone
… tried to understand the nature of mineral and collagen changes in diffuse damage and repaired tissue. Then we tested the hypothesis that the repair of Dif.Dx regions in bone, as assessed functionally by recovery of mechanical properties, can occur ex-vivo in the absence of viable osteocytes. …
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Aligned Fibrillar Collagen Matrices for Tissue Engineering
… cell behaviour for tissue regeneration. Aligned collagen fibrils were deposited on planar substrates from collagen solutions streaming through a microfluidic channel system. Collagen solution concentration, degree of gelation, shear rate and pre-coating of the substrate were demonstrated to …
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THE ROLE OF NON-MUSCLE MYOSIN IN TENDON AND ATTACHMENT UNIT FORMATION AND MATURATION
… reduced, corresponding with a decrease in collagen fibril diameter. This deficit in growth coincided with an aberrant actin cytoskeleton which ultimately resulted in tendon degeneration, as P112 Myosin dKO tendons exhibited increased proteoglycan content, matrix disorganization, ectopic …
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Freezing-induced deformation of biomaterials in cryomedicine
… length scales including nanometer-scale protein fibrils, single cells and whole tissues. A combination of rigorous experimentation and computational modeling is used to characterize post-thaw biomaterial structure and properties, predict biomaterial behavior and assess its post-thaw biological …
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Nonlinear Viscoelastic Behavior of Ligaments and Tendons: Models and Experiments
… tendons. The mechanical behavior of bundles of collagen fibers which form ligaments and tendons was investigated. Axial stress-stretch data and stress relaxation data at different axial stretches were collected by testing rat tail tendon fascicles. The experimental results demonstrated, for the …
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Investigation into the structure and function of Hsp47
Collagen is the most abundant protein in mammals and is the main protein of connective tissue in animals [1]. It is a fibrous structural protein that is the major component of the extracellular matrix, which provides great tensile strength to ligaments, tendons, bone and skin, for example. Hsp47 is …
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Time dependent mechanical behavior of mammalian collagen fibrils
Collagen fibrils, with dry diameters of the order of 100 nm, are the fundamental building blocks in connective mammalian tissues. While the mechanical behavior of tissues has been studied extensively and was shown to follow non-linear viscoelasticity, as similar quantitative understanding of the …
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