Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"cold exposure"”.
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Chromatin-based memory of prolonged cold exposure in Arabidopsis thaliana
… thaliana is repressed by the prolonged cold of winter, and repression is maintained in subsequent warm conditions. The molecular complexes involved in modulating FLC chromatin are vital for FLC regulation and are conserved among plants and animals, making FLC a paradigmatic system for …
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The Effects of Temporal Cold Exposure and Caste Differences on Gene Expression and Epigenetics of Common Bumble Bee Species
Under harsh environmental conditions, such as cold stress, organisms must quickly be able to mount an appropriate response to minimize injury and avoid death. Molecular mechanisms offer a rapid method to help mitigate effects of cold exposure. However, more research is needed to better understand …
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Cold-Induced Metabolic Changes in Lean, NAG-1 Transgenic Mice
… process of burning stored fats to generate heat. Cold exposure is a known way to activate brown adipose tissue through b3-adrenergic signaling. This signaling pathway causes an upregulation of thermogenesis in brown adipocytes and beige adipocytes, which is white adipose tissue that “browns” and …
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Mechanisms Underlying Variation in Insect Chill Tolerance: The Role of Ion and Water Transport
… temperatures; loss of this homeostasis in the cold likely contributes to chronic chilling injury, and reestablishment of homeostasis is required for recovery from chilling. Both plastic and interspecific variation in cold tolerance correlates with enhanced defense of water and ion homeostasis …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… elevation in thermogenic beige adipose tissue. Cold exposure is the main stimulus for beige adipose tissue activation. It is well understood that the cold activation of beige adipose tissue involves the central nervous system (CNS) conveying the cold stimulus to the sympathetic nervous systems …
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
… Notably, ERαvlVMH inhibition also impairs cold-induced food intake and BAT thermogenesis, resulting in lethal phenotypes during chronic cold exposure. Post hoc histology analysis revealed that ERαvlVMH inhibition induces adipose tissue whitening. Finally, we explored the anatomical …
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The role of brown adipose tissue on substrate metabolism and insulin sensitivity in humans
… (BAT-) detectable BAT under prolonged mild cold and thermoneutral conditions using infusion of stable isotopic tracers, hyperinsulinemic-euglycemic clamps, indirect calorimetry, and positron emission tomography-computed tomography. A novel method was established to sample the supraclavicular …
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Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
… the genes and pathways that are involved in cold-induced cell death have not been systematically explored. In this thesis, we conduct two genome-wide CRISPR-Cas9 screens in both a cold-sensitive (K562) and cold-resistant (BHK-21) cell line, and uncover GPX4 and related selenocysteine …
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A Multi-Organ Role for Nocturnin in Post-Transcriptional Regulation of RNA
… that Nocturnin is acutely induced in response to cold and mitochondrial-encoded mRNAs in Noc-/- BAT exhibit impaired stability upon cold exposure. Global analysis of cold-induced changes in the transcriptome of Noc-/- and wild type (WT) mice reveal down-regulation of glycan biosynthesis genes in …
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THE EFFECT OF WINTER VERSUS SUMMER RUNNING ON LOWER EXTREMITY MUSCULOSKELETAL INJURY RATE IN RECREATIONAL RUNNERS
… of cryotherapy on body tissues suggest that cold exposure can decrease performance measures, including proprioception, strength, and agility. Since a decrease in proprioception and strength have been linked with an increase of injury rates, this suggests that exposure to cold conditions may …
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Effects of estrogen and progesterone on tolerance to thermal stress
… thermoregulatory responses during acute heat and cold exposure. However, body weight was highest in P treated rats. The body weight of EP treated rats was also greater than the control animals and those treated with E alone.
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In vivo investigations of photoplethysmograms and arterial oxygen saturation from the auditory canal in conditions of compromised peripheral perfusion
… more naturally by exposing the volunteer to cold temperatures of 10C for 10min. Normalised Pulse Amplitude (NPA) and SpO2 was calculated from the PPG signals acquired from the ear canal, the finger and the earlobe. By the end of the cold exposure, a mean drop of > 80% was found in the NPA of …
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Effects of feeding supplemental fat to cows in late gestation on cold tolerance in newborn calves
… and thermogenic response during short-term cold stress were examined in fall-born neonatal beef calves. Pregnant fall-calving heifers (n = 15) were randomly assigned to three dietary treatments: Control (CON, n=5), Safflower seed (SAF, n=5), or Cottonseed (COT, n=5) supplement. Hay-based …
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Predicting the impact of climate change on vernalization for Arabidopsis thaliana
… thaliana plants require a prolonged period of cold, known as vernalization, to ensure prompt floral transition occurs in spring. This thesis addresses the question of whether partial saturation of cold requirements might delay flowering under future climate scenarios. Laboratory experiments set …
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Effects of Aquatic Therapy on Vagal Tone and Social Behaviors in Individuals with Autism Spectrum Disorder
… such as deep breathing, physical exercise and cold exposure have been shown to increase vagus nerve activation (Mason et al.,2013; Presmanes et al., 2015; Yuan et al., 2001). Using a quasi-experimental block design, the present study evaluated the effect of aquatic therapy on vagal tone as well …
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Insights into the seasonal ecology and thermal biology of the lesser grain borer, Rhyzopertha dominica (Coleoptera: Bostrichidae)
… interest in alternative strategies such as cold-based interventions, including ambient and chilled aeration. Yet, the effectiveness of these methods depends on a variety of factors, including grain type, insect density, environmental conditions, and exposure duration. Here, our study …
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Unravelling the Ecological and Evolutionary Mysteries of the Rough Fescue Grasses F. Hallii and F. Campestris.
… Chapter 2 investigates the role of dormancy and cold exposure on rough fescue seed germination using a comparative germination assay between F. hallii and F. campestris. It finds that the temperature and duration of seed storage has significant impacts on rough fescue germination, and can greatly …
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Study of the androgenic activity of the regenerating adrenal cortex.
… appeared similar in androgen level but, exposure to severe cold (-5°C) depressed the level of circulating androgens. The cold exposed intacts tended to recover but enucleates remained depressed after 12 days of cold exposure; cold exposed castrates did not display an increase in …
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The Role of Thada in Energy Homeostasis
… interpret as a potential adaption to the extreme cold. In this thesis, I have performed in vitro and in vivo approaches and confirmed that the ablation of THADA caused increased ATP hydrolysis and Ca2+ transport efficiency of SERCA and affected cellular bioenergetics in primary skeletal muscle …
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Photoplethysmography for non-invasive measurement of bone hemodynamic responses to changes in external pressure
… experiments including arterial occlusion, cold exposure, skin occlusion and nitroglycerin exposure were performed. Single-limb pressure chamber experiments were performed over a range of pressures from -50 to +50 mmHg to characterize the responses to changes in external pressure and to …
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