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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"colchicine"”.
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Embryogenic response of potato anther culture to colchicine
Colchicine, an antimicrotubule agent, has enhanced the androgenic response of cruciferous and graminaceous species. Our objectives were to determine if colchicine treatments enhanced androgenic embryo production in diploid potato, and if colchicine treatments during anther culture affected the …
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Colchicine-induced polyploidy in the azalea cultivar Coral Bells
… day following the terminal pinch with one of 3 colchicine concentrations (.25%, .5%, .75%). The remaining plants were pinched the same day and the consecutive day treatments were started 2 days after the pinch. Plants were treated for 2, 3, or 4 consecutive days. Colchicine-induced polyploidy …
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Quantitative Real-Time PCR Analysis of Colchicine Pathway and Rhizome Developmental Genes
Colchicine is an alkaloid with a long history of use as a treatment for several conditions, such as gout and Familial Mediterranean Fever, but has shown potential as an anti-cancer drug due to its anti-mitotic properties. As demand for colchicine increases, traditional production methods lag behind …
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Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors
… research efforts have attempted to develop colchicine binding site inhibitors, which are reported to be significantly less susceptible to multidrug resistance and have therapeutic advantages over agents that target the taxane and vinca alkaloid site. Herein, we evaluated the anticancer …
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The effects of the tubulin-binding drug, colchicine, on the electrophysiological aspects of phototransduction in toad rod photoreceptors
Colchicine, known for its antimitotic properties, its effects on neuronal conductances and its use as a treatment for acute gout, was found to affect phototransduction in toad rods during pharmacologic screening of cytoskeletal antagonists. Colchicine superfusion onto intact retinas hyperpolarized …
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Design and optimization of polymeric nanoparticles for the delivery of a novel computationally designed colchicine derivative for cancer application
L'abstract è presente nell'allegato / the abstract is in the attachment
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Genetic improvement of selected indigenous Cucurbitaceae species important for food and medicinal purposes in KwaZulu-Natal, South Africa
… or in the field (with and without bags). Colchicine treatment of seeds before and after incubation for germination was used to induce polyploidy in both of these Cucurbitaceae species. The effectiveness of colchicine in inducing polyploidy (genetic improvement) in the roots and shoots of …
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Differential gene expression in Behcet's disease and differential anti-tumor effects of Tim3 pathway blocking molecules
… I Differential expression of genes according to colchicine responsiveness in Behçet’s disease Behçet disease (BD) is a chronic relapsing, systemic inflammatory disorder which is treated with colchicine. However, some patients are not responsive to it. In this study, I wanted to explore the …
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Efficient production of doubled haploid plants through antimicrotubule agent treatment of anther-derived maize callus and the RFLP analysis of the maize anther culture response
Antimicrotubule agents, colchicine, amiprophos-methyl (APM), pronamide, oryzalin and trifluralin were used to induce chromosome doubling of maize anther-derived haploid callus before plant regeneration. Without treatment with these agents, all the plants regenerated from the callus were haploid. …
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Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases
… end cap. All prodrugs were conjugated to a colchicine derivative (ICT 2552) which is a vascular disrupting agent causing tumour vasculature shutdown and consequently, tumour necrosis. ICT 3146, ICT 3019, ICT 3120 and ICT 3115 prodrugs showed significant stability in normal tissues and …
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Characterization of Luteinizing Hormone - Releasing Hormone (Lhrh) Release From Rat Hypothalamus Using an in Vitro System
… a microtubular transport mechanism, since colchicine (10('-6) or 10('-5) M) inhibited K('+)-stimulated LHRH output. However, 10('-4) M colchicine dramatically increased LHRH release as well as hypothalamic LHRH content by an unknown mechanism.
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Molecular Mediators of Macrophage Foam Cell Formation and Atherosclerosis and their Pharmacological Modification
… of the well-established, anti-gout drug, colchicine; and (2) the genetic knock-out and pharmacological inhibition of eukaryotic elongation factor 2 kinase (eEF2K), a structurally unique enzyme known to be important for protein translation in cells under different stress conditions. …
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Cluster Determinant 44 (CD44) Receptor and Gout: Mechanistic Role in Pathogenesis and Therapeutic Targets
… increased over the past two decades. Colchicine is considered one of the first-line treatments for the relief of the symptoms associated with gout attacks. However, the use of colchicine for gout therapy has limitations due to the severe adverse effects, including fatalities. Acute …
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Design and synthesis of indole-based analogues of OXi8006 as inhibitors of tubulin polymerization and their incorporation as payloads in drug-linker constructs.
… tumor vasculature. OXi8006 binds to the colchicine site on α,β-tubulin heterodimers, inducing a conformation shift from a straight to a curved structure. This conformational change inhibits tubulin polymerization, leading to cell cycle arrest and apoptosis. To gain a deeper understanding …
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A study comparing the effects of vincristine with those of ionizing radiation on the root meristem of Vicia faba
… at the metaphase stage, similar to that of colchicine andcolcimid. Clinically, vincristine has been found to produce a complete remission in patients with acute leukaemia. Tumour regression in patients with Hodgkin's disease, lymphosarcoma and certain childhood solid tumours have also been …
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The Role of Microtubules in Secretion
… system has been studied by electron microscopy, colchicine binding assay for the microtubule protein tubulin and radioimmunoassay. These assays for microtubule proteins have been performed on mouse pancreas homogenates to test whether a correlation exists between the assembly of microtubules in …
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Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents
… for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations.
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Target Based Design And Synthesis of Heterocycles in the Potential Treatment of Cancer and Opportunistic Infection
… Among the various classes of such agents, the colchicine site binding agents are particularly important as they circumvent the Pgp and β-III tubulin mediated clinical resistance. These resistance mechanisms, when manifested, are a major reason for the failure of clinically used agents such as …
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Implications for Microtubule Mediated Ethylene Effects in Pea Stem Sections
… have been investigated. Low temperature mid colchicine. both known microtubule depolymerization agents, reverse the effects of ethylene in straight growth tests. Low temperature (6 C) also profoundly reduces the effects of the gas in terms of swelling, hook curvature, and horizontal nutation. …
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Design and synthesis of benzosuberene and tetracyclic-based molecules inspired by natural products as inhibitors of tubulin polymerization and preparation of drug-linker constructs to facilitate tumor selective targeted delivery.
… Natural products such as combretastatin A-4 and colchicine that bind to the colchicine site (functioning as potent inhibitors of tubulin polymerization and antiproliferative agents) have been evaluated clinically and have inspired countless analogues and derivatives. The Pinney group has …
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