Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 116 for “"cognitive dysfunction"”.
-
Cognitive Dysfunction in Older Breast Cancer Survivors
… (BCS) living in the United States report cognitive dysfunction. However, little is known about cognitive dysfunction among older BCS, who may be at greater risk. Therefore, the purpose of this dissertation was to characterize cognitive dysfunction in older BCS. Specific aims included: (1) …
-
Assessing cognitive dysfunction in the hemodialysis population
… requiring hemodialysis treatment experience cognitive impairment due to a variety of risk factors; most of which stem from chronic kidney disease (CKD) and the dialysis process itself. The purpose of this study was to assess changes in cognitive functioning in maintenance hemodialysis (MHD) …
-
MicroRNA Dysregulation in Neuropsychiatric Disorders and Cognitive Dysfunction
… 22q11.2 microdeletions result in specific cognitive deficits and high risk to develop schizophrenia. Analysis of Df(16)A+/- mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines as well as microRNA dysregulation in brain. We show a …
-
The Relationship between Subsyndromal Symptomatic Depression and Cognitive Dysfunction
… established, the interaction between SSD and cognitive functioning has not been explored in depth. Further, clinicians have long postulated that depression is not a monolithic disorder but rather a group of disorders which are heterogeneous in onset, symptoms, course, and treatment. One …
-
Usefulness of MR Spectroscopy in Differential Diagnosis of Cognitive Dysfunction
"서론: 인지기능 장애의 조기진단과 치료에 대한 관심이 높아지면서 알쯔하이머병, 경도인지장애, 주관적인 기억장애 등의 감별진단을 위한 많은 영상의학적 진단 방법들이 개발되고 있으며 그 중 자기공명분광영상은 비침습적으로 병태생리학적 기전을 연구할 수 있어 널리 이용되고 있다. 본 연구에서는 인지기능 장애 환자들에게서 자기공명분광영상을 시행하여 각 질환간의 차이와 각 영역별 인지 장애 정도와의 상관성을 알아보고자 하였다. 연구대상 및 방법: 2008년 7월부터 9월까지 아주대학교병원 신경과 치매 클리닉에 내원한 환자 중 …
-
Cognitive and Non-Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease
… tasks that efficiently and accurately assess cognitive function during pre-clinical trials would be useful in developing novel treatments for Alzheimer's disease (AD) patients. The Bussey-Saksida touchscreens employ various tasks similar to those used in humans to effectively evaluate …
-
Risk Factors for Postoperative Cognitive Dysfunction in Older Adults Undergoing Major Noncardiac Surgery
Background: Postoperative cognitive dysfunction (POCD) is a deterioration in cognitive function that occurs after surgery as measured by neuropsychological tests. The purpose of this study was to determine the incidence and risk factors for POCD in older adults three months after major noncardiac …
-
Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis
… survivors report long-term chemotherapy-induced cognitive dysfunction (CICD) characterized by deficits in working memory, processing speed, and executive functioning. Currently, no interventions for CICD have been approved by the US Food and Drug Administration. I show here that a 14-day …
-
The role of synapse biology in intellectual disability. Many roads to cognitive dysfunction
Contains fulltext : 166980.pdf (Publisher’s version ) (Closed access)
-
Prediction of later cognitive dysfunction in reading from preschool perceptual, perceptual-motor and auditory sequential processing tasks : a discriminant analysis
The purpose of this study was to evaluate the effectiveness of group thermal biofeedback training and relaxation as a means of changing locus of control. Additionally, the stability of the locus of control change, over time, was examined. Lastly, the proportion of achievement motivation which can …
-
Acute cognitive dysfunction, short and long-term outcomes and the impact of medical follow-up following hospitalisation for general medical illness in Cape Town, South Africa
… requirement for institutional care, persistent cognitive deficits, and functional decline. The Gold standard for testing delirium continues to evolve but requires lengthy bedside cognitive testing by trained specialists. In a busy acute general medical setting, the use of these tools is …
-
Factors Related to Mental Health Status in Elderly Type 2 Diabetes Patients
OBJECTIVE: To evaluate the prevalence of cognitive dysfunction, physical disability, and depressive status in elderly diabetes patients, and their relationship with diabetic parameters. MATERIALS AND METHODS: One hundred and thirty three diabetes patients aged 65 years or over were evaluated for …
-
Investigating Cognitive Functioning in a Sample of Spinal Cord Injury Inpatients, in Relation to the Cognitive Demands of their Specialized Rehabilitation Program: A Pilot Exploratory Study
… programs have significant and specific cognitive demands, requiring patients to acquire knowledge and new skills while adjusting to their profoundly altered physiology. Existing research from high income countries (HIC) has shown that SCI is associated with cognitive dysfunction, which …
-
Validation of an animal model of cognitive dysfunction associated with schizophrenia. Development and validation of the novel object recognition task using behavioural manipulations and psychotomimetic dosing regimens to induce cognitive deficits of relevance to schizophrenia in hooded-Lister rats.
… with continual and treatment resistant cognitive deficits which are now recognised as a core feature of the disease. The aim of the studies reported in chapter 3 were to establish a set of objects with equal preference in the NOR (novel object recognition) test. Furthermore, the …
-
Measuring Dementia of the Alzheimer Type More Precisely
Alzheimer?s disease (AD) progressively impairs cognitive and functional abilities. Research on pharmacological treatment of AD is shifting to earlier forms of the disease, including preclinical stages. However, assessment methods traditionally used in clinical research may be inappropriate for …
-
Cognitive dysfunction and schizophrenia : Modelling attentional impairment with psychotomimetics. Investigating attentional impairment and structural brain abnormalities following phencyclidine administration: Enhancing translatability between preclinical and clinical tests of attention utilising the modified 5-choice task in rats - the 5-Choice Continuous Performance Test.
… in order to to determine the ability of inducing cognitive-specific disruptions in attentional functioning. The hypothesis that sub-chronic exposure to PCP would result in persistent attentional impairment was tested, using the 5-choice serial reaction time task (5-CSRTT). The 5-CSRTT assesses not …
-
Randomized controlled trial of two telemedicine medication reminder systems for older adults with heart failure
… Furthermore, many HF patients suffer from cognitive dysfunction, which could reduce medication adherence. The purpose of this randomized feasibility study was to examine the impact of two medication reminder systems on medication adherence over 28-days of monitoring. It was hypothesized …
-
Traumatic Brain Injury Accelerates Alzheimer’s Disease Pathology in the TgF344-AD Rat Model
… of AD pathology and associated neurological and cognitive dysfunction in the TgF344 AD rat model. Methods: Male and female TgF344-AD rats (3 months old) were randomized to receive parasagittal fluid percussion injury, sham injury, or naïve (N=10-16 rats/group). Neurobehavioral tests (beam walk, …
-
An Experimental Investigation and Conditional Process Analysis of the Role of Catastrophizing in the Pain — Working Memory Nexus
… bidirectional relationship between pain and cognitive dysfunction, especially working memory. Despite this extensive body of research, the pain–working memory relationship is poorly understood. Pain catastrophizing – exaggerated negative cognitive and emotional responses towards pain – may …
Page 1 of 6