Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"cognitive disorders"”.
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HIV-associated cognitive disorders in children and adolescents: methodological investigations and validating a quick screening tool
… Perinatal HIV-infection is associated with both cognitive and functional impairment. Accurate measurement and screening for these conditions is key in ensuring that these vulnerable children and adolescent receive the care they need. Objectives I sought to carry out the following: 1) to undertake …
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Depression and PTSD as Predictors of Dementia and Other Cognitive Disorders among Veterans based on Race and Sex
… associated with dementia and other forms of cognitive impairment. As this population continues to age and diversify in the upcoming years, risk factors specific to their circumstances must be examined. Importantly, similar patterns of health disparities that persist in the general population …
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Neuroinflammation and Cognitive Impairment in the Aged: Implications for Nutritional Intervention
… as well as prolonged hippocampal-dependent cognitive deficits, compared to adults when administered lipopolysaccharide (LPS) to mimic a peripheral infection. The excessive production of inflammatory cytokines such as interleukin (IL)-1beta within the brain is proposed to underlie acute …
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Functions of Mediodorsal Thalamic Astrocytes in Cue-Based Learning
… with the prefrontal cortex, facilitating cognitive and decision-making functions. Despite the MD's involvement in higher-order relays, the precise mechanisms underlying its astrocytic activity, its contribution to synaptic plasticity, and the subsequent effects on cognitive processing …
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Factors affecting neuropsychological testing in the elderly and the use of a newly developed virtual reality test. Implications for the accurate and early diagnosis of Alzheimer's disease.
… the diagnosis of Alzheimer’s disease and other cognitive disorders. However, the testing process may be affected by subtle external factors which if not controlled for may have the ability to affect the scores obtained. The primary aim of this thesis was to investigate the effects of some of …
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The HIV-1 entry inhibition capabilities of Isoflavones
… 60% of treated individuals will show minor cognitive disorders due to infection, immune reconstruction inflammatory syndrome occurs in a high number of individuals of African descent as a treatment side-effect, and treatment resistance occurs commonly both with long-term infected individuals …
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Investigation of the Effects of Antipsychotics on CNS Insulin-mediated Brain Glucose Uptake using 2DG Autoradiography
… factor in the development of age-related cognitive decline and Alzheimer’s disease (AD). As such, aberrant brain insulin signaling has been posited to lie at the crossroads of metabolic and cognitive disorders. In recent years, a greater focus has been placed on using insulin delivered to …
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Biomarker-And Pathway-Informed Polygenic Risk Scores for Alzheimer's Disease and Related Disorders
… biological pathway-informed PRS to prediction of cognitive changes among older women with breast cancer (BC). Results from PRS analysis of the multicenter Thinking and Living with Cancer (TLC) study indicated that older BC patients with high AD genetic susceptibility within the immune-response and …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… is associated with a wide range of brain disorders including psychological, neurological and developmental disorders. Unfortunately, currently available drugs targeting Nav channels are directed against highly conserved domains of the α-subunit of all Nav channels, and as such they have …
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Biological motion processing in typical development and in the autism spectrum
… for exploring the underlying etiology of social cognitive disorders such as the autism spectrum. </p> <p>In an initial experiment, typical adults observed BM point-light displays of a human actor (UM) as well as their spatially scrambled counterparts (SM), in both an unattended distractor task as …
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The role of mental representations of order in mathematical cognition: a developmental approach
… whether ordering skills are linked to other cognitive disorders(such as Gerstmann’s syndrome), as well as assessing whether order-processingskills are also linked to maths achievement in children educated vianon-mainstream educational pedagogies, such as the Steiner-Waldorf andMontessori …
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Functional characterization of Phosphodiesterase-4A in behavior and obesity
Cognitive disorders such as depression, anxiety, and senescent-induced memory loss are a growing pandemic in the world. Anxiety is the most common psychiatric disorder in America, affecting upwards of 50 million people a year; depression has a lifetime prevalence of 20% of the population, and it's …
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Developing Deep-Learning Methods for Diagnosis and Prognosis of Pediatric Progressive Diseases Using Modern Imaging Techniques
… of image diagnosis and interpretation for cognitive disorders in infants. We propose to automate neuroimaging analysis with artificial intelligence algorithms. This novel approach can be used to improve the accuracy of TSC diagnosis and treatment. Deep learning (DL) is among the most …
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Ruolo del recettore CB1 cellulare e sub-cellulare in cellule D1-positive dell'Ippocampo nei Processi della Memoria
… contribution in brain mitochondrial activity and cognitive functions. Specific chemogenetic activation of mitochondrial G- protein signaling results in increased mitochondrial respiration which in turns rescues THC-induced amnesic effect. Overall, the results of this Thesis indicate the mechanisms …
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Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease
… scans in healthy controls and patients with mild cognitive impairment. We found that a pathological level of P-tau and WMLs in the parietal lobes independently increased the risk of developing AD dementia, but that the risk was considerably higher for patients that had both. Next, we analyzed the …
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A Comparative, cross-cultural study of the prevalence and correlates of late life depression in low and middle income countries
… the probable increased risk of developing future cognitive disorders. Rapid population ageing in LMIC presents a major challenge to health care policy-makers. Within this, attention will need to be given to significant prevalence of late-life depression, comorbid with, and complicating chronic …
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Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia.
… assessments in which they display pro-cognitive effects, particularly in drug-induced amnesias. It is important to establish whether there are any changes in H3R expression in normal physiological aging and in age-related human dementias. Based on quantitative [3H] GSK189254 …
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Isopeptide and Ester Bond Ubiquitination Regulate Degradation of the Human Dopamine Receptor 4
… which is used to treat schizophrenia and other cognitive disorders. The hD4R gene is unique among the superfamily of GPCR-encoding genes because within the human population, it contains a variable number of tandem repeat (VNTR) exon polymorphism. Because of the VNTRs, the length of the primary …
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Evaluating Microglia Dynamics in Blast and Impact-Induced Neurotrauma and Assessing the Role of Hemostatic Nanoparticles in Microglia Activation
… have sustained a TBI to develop behavioral and cognitive disorders following injury, and these symptoms can present as delayed onset, causing diagnosis to be a major feat when planning for treatment and long-term healthcare. Both preclinical and clinical studies report the neuropathological …
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Finding Common Ground: The Common Marmoset as a Model to Accessing and Providing Insight into the Social Brain
… new light on transcriptional differences in cognitively relevant cells across species. We implemented retro-vTRAP in marmosets, macaques, rats, and mice and found a single conserved, enriched gene ontology set across marmosets and the rodents. This gene set is involved in negative regulation …
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