Global ETD Search
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Showing 1 to 3 of 3 for “"cofilin-actin rod"”.
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Lipid raft signaling in cofilin-actin rod formation induced by amyloid-β and TNFα
Rod-like inclusions (rods), composed of actin saturated with cofilin, are induced in neurons by energetic and oxidative stresses, excitotoxic levels of glutamate, and amyloid beta treatment. Cofilin is an F-actin assembly regulatory protein critical to various actin-dependent processes, such as …
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Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
Actin-Cofilin rods are an important marker of neurodegenerative disease and are commonly observed in the neurons of patients with Alzheimer's disease. The goal of this research is to investigate peptide and small-molecules for their potential to inhibit actin-cofilin rod formation in cells. These …
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Actin dynamics in silico, in waves, and in rods
The current paradigm of actin dynamics and superorganization has advanced in the past decade from emerging technologies and perspectives, which include the discovery of actin nucleators, real time imaging of the dynamics of single filaments in vitro, and single molecule imaging of actin …