Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 252 for “"cofactors"”.
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Cofactors in Coronavirus Entry
… the coronavirus spike proteins as well as other cofactors required for S-mediated entry into cells.</p><p>The S proteins are set apart from other viral and cellular membrane fusion proteins by their extensively palmitoylated membrane-associated tails. In our experiments, substitution of alanines …
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Chemical Modification of Iron-Sulfur Cofactors
Iron–sulfur (Fe–S) cofactors are multi-metallic clusters that are found in all living organisms. The presence of multiple metal centers enables these cofactors to perform some of the most challenging chemical transformations in biosphere, such as activation of strong C–H bonds and reduction of N2, …
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Genetic Analysis of Rna Exosome Complex Cofactors
… is inactive by itself and requires different cofactors in the nucleus and cytoplasm to perform different localized functions. This exo-9 core can associate with one or two catalytic subunits, including Rrp44/Dis3 and Rrp6 in yeast and DIS3 or DIS3L and RRP6/EXOSC10 in humans. The RNA exosome …
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Study of Nitrogenase Cofactors bound to Nitrogenase Carrier Proteins
Nitrogenases employ Fe-S clusters as catalytic cofactors to perform the kinetically challenging reduction of N₂ to NH₃. The unique reactivity of nitrogenase cofactors is derived in part from the complexity of their cluster composition, featuring eight metal sites, at least seven of which are Fe. …
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Studies of Reaction Mechanisms Requiring Low Molecular Weight Thiol Cofactors
The methyl-transfer reaction between methylcobalamin and 2-mercapto-ethanesulfonic acid (Coenzyme M) was investigated. We propose that this reaction is a thiyl radical promoted homolytic cleavage of the cobalt-carbon bond rather than the nucleophilic attack by thiolate anion which has been pro
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Isolation and functional characterization of cofactors of RNA polymerase II transcription
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Excited state charge redistribution and dynamics of flavins, flavorproteins, and their cofactors
The excited state electronic structures of several biologically important chromophores were studied by Stark spectroscopy. The extent of charge redistribution upon excitation to the lowest excited states of the oxidized and semiquinone forms of flavin adenine dinucleotide (FAD) bound to the light …
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NUTRITIONAL STATUS AND COFACTORS IN ADOLESCENTS: EVIDENCE FROM AN ITALIAN MULTICENTRIC COHORT
Adolescence represents a developmental period characterized by rapid physical growth, hormonal changes, and evolving dietary behaviors, with an impact on the establishment of dietary habits that influence health trajectories into adulthood. Understanding the multifaced determinants of nutritional …
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Structural examination of trypanosomatid tubulin-binding cofactors and pteridine reductase 1 inhibition
… of cell morphology. Five tubulin-binding cofactors (TBC, named A-E) are proteins implicated in the folding, polymerisation and processing of tubulin, the major component of the trypanosomatid cytoskeleton. At the initiation of this study, there was no structural information available for …
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Using Unnatural Amino Acids and Nonnative Cofactors for Metalloprotein Design and Engineering
Different positions for anchoring the salen cofactor to the Mb scaffold were observed to affect both the rate and selectivity of the artificial enzyme in a modular and accumulative fashion. Molecular dynamic simulations indicate that these changes may be due to the steric effects of the linker arms …
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Enzyme-like catalysis by single chain nanoparticles that use transition metal cofactors
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Understanding the Speciation of Ruthenium Arene Complexes as Precursors to Unnatural Enzyme Cofactors
Ruthenium arene complexes have been extensively explored as metallo-pharmaceuticals and as small molecule catalysts. Exploring the overlap between these areas, this thesis describes a body of work aimed at quantitatively understanding the biological speciation and catalytic behaviour of ruthenium …
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Protein Specificity Dictates Proper Sulfur Transfer in the Biosynthesis of Thio-cofactors in Bacteria
… clusters, thio-nucleosides, and other thio-cofactors are critical players in several biological processes. The sulfur element present in these molecules is predominantly originated from L-cysteine through activation by cysteine desulfurases and is relayed to specific pathways involving the …
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The Indivisible System: Modeling The Metal-Pterin-Dithiolene System In Molybdenum And Tungsten Cofactors
… the tungsten cofactor (Tuco) the most redox rich cofactors in all of biology. This research focuses on the development of new pterin-dithiolene synthetic modeling systems for Moco. The knowledge gained from the characterization of these compounds is applied to the enzymes, furthering our …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… orphan nuclear receptors SHP and FXR and their cofactors in health and disease states.
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Generating artificial metalloenzymes containing new-to-nature organometallic cofactors via controlled ligand exchange and microfluidic screening technologies
… (ArMs) containing non-natural organometallic cofactors have commanded increasing attention for their ability to catalyse transition-metal dependent transformations with the selectivity and mild conditions associated with enzymes. This work investigates novel ArMs where an organometallic …
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Investigating the Distribution and Biosynthesis of Modified F<sub>430</sub> Cofactors in Methanogenic and Methanotrophic Archaea
Methanogenesis is the biological production of methane and is utilized by methanogenic archaea (methanogens) to generate energy. This process is responsible for 70% of total atmospheric methane, a potent greenhouse gas and an important energy source (natural gas). In the future, reversing …
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Genetic Analysis of Hox Transcription Factors and Cofactors in the Regulation of Programmed Cell Death in C Elegans
It has been well established that blocking apoptosis can promote cancer. Throughout the animal kingdom, apoptosis is exquisitely regulated in cell-specific and context-specific ways to ensure proper development and tissue homeostasis. In many cases, transcriptional pathways carry out this …
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