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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"cofactor specificity"”.
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Improving Methanosarcina genome-scale models for strain design by incorporating cofactor specificity and free energy constraints
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-04-22T20:19:19Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Richards_Matthew.docx: 566731 bytes, checksum: 34f812c17c0944f31f7b5fba2a34d536 (MD5) Richards_Matthew.pdf: 1474395 bytes, …
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Understanding, Optimization, and Application of Phosphite Dehydrogenase: Advancing NAD(P)H Regeneration
… biocatalytic reactions that utilize these cofactors. PTDH shows promise for NAD(P)H regeneration and was therefore optimized for industrial application. The cofactor specificity of PTDH was relaxed by rational design using the homology model. Cofactor specificity was changed from 100-fold …
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Toward a General Dehydrogenase Enzymatic Scaffold for Industrial Biocatalysis
… of reactions with high efficiency and exquisite specificity. As such, they lend themselves well for use in a myriad of applications from the production of fine chemicals to use in biofuel cells. Demand for enzymes with novel specificities has risen in recent years, as they are "green" catalysts …
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Understanding and Harnessing the Structural Features that Govern HMG-CoA Reductase Activity
… to mevalonate using two equivalents of the cofactor NAD(P)H, is part of the mevalonate pathway, found in all kingdoms of life. This pathway is at the heart of natural product biosynthesis constituting one of the obligate routes to producing the building blocks for isoprenoids, which …
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Mechanistic Studies of Flavin-Dependent Monooxygenases Involved in Bacterial Defense and Plant Metabolism
… revealed residues essential for catalysis and cofactor specificity. The flavin-dependent S-monooxygenase TvMAS1 from the society garlic Tulbaghia violacea has been implicated in the production of marasmin, a natural product with human health benefits. We find that TvMAS1 has a broad substate …
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Engineering a Fungal L-Arabinose Pathway Towards the Co-Utilization of Hemicellulosic Sugars for Production of Xylitol
… chemical synthesis include high selectivity and specificity, increased yield, and function under milder conditions without the need for toxic metals, organic solvents, strong acids or bases, or high pressures and temperatures. However, naturally occurring enzymatic pathways are often times not …
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Engineering a Fungal L-Arabinose Pathway Towards the Co-Utilization of Hemicellulosic Sugars for Production of Xylitol
… chemical synthesis include high selectivity and specificity, increased yield, and function under milder conditions without the need for toxic metals, organic solvents, strong acids or bases, or high pressures and temperatures. However, naturally occurring enzymatic pathways are often times not …
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Metabolic engineering of Saccharomyces cerevisiae for efficient ethanol production from pentose sugars
… the redox imbalance that results from different cofactor preference in oxidation and reduction reactions, and a suboptimal metabolic flux through different catalytic steps. A lot of research has been carried out to improve pentose utilization in S. cerevisiae by targeting different aspects of …