Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"coenzyme q"”.
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The Effect of PDSS2, a Component of the Coenzyme Q Biosynthetic Pathway, on Murine Oocyte Embryo Development
… to contribute is the reduced availability of coenzyme Q (coQ), a component of the mitochondrial respiratory chain, as it has been previously shown that both transcript and protein expression of various coQ biosynthetic enzymes decrease in aged murine oocytes. To further explore the impact of …
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Structure-based theoretical characterisation of the redox-dependent titration behaviour of cytochrome bc1
Cytochrome bc1 is a coenzyme-Q-cytochrome-c-oxidoreductase that represents complex III of the mitochondrial respiratory chain. It spans the inner mitochondrial membrane and uses the free energy of electron transfer from coenzyme Q (CoQ) to cytochrome c to shift protons across the membrane. The …
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Novel approaches to treat mitochondrial complex-I mediated defects in disease
… these methods we evaluated the efficacy of the coenzyme-Q derivative idebenone, a proposed antioxidant. Surprisingly, in both chemically induced models of I/R and I/R in the intact heart, we see no antioxidant-based mechanism for rescue. The mechanistic insight we gained from these models of I/R …
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Effect of a Single High-Fat Meal and Vitamins on the Circulatory Response to Local Heat in Koreans and Caucasians
… (1000mg vitamin C, 800IU vitamin E, and 300mg Coenzyme Q-10) for 14 days, the same measurements were repeated. The results of this investigation showed that the skin BFR to vascular occlusion and local heat at baseline was significantly lower in Koreans than Caucasians. The skin BFR to vascular …
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Investigating complex I dynamics and ROS production in ischaemia-reperfusion injury
… force (∆p) in conjunction with a reduced coenzyme Q (CoQ) pool, with the required electrons deriving from succinate oxidation. ROS causes severe damage to cellular components, leading to cell death and ultimately to chronic inflammation. In order to expand our knowledge on the role and …
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Developing methods for measuring mitochondrial redox status and membrane potential in the isolated perfused heart
… succinate levels, the redox status of the coenzyme Q (CoQ) pool, ATP and ADP levels, and complex I activity during ischaemia-reperfusion with good temporal resolution providing critical insight into the conditions required for RET. Finally, I established a method for measuring …
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Protein Coevolution and Coadaptation in the Vertebrate bc1 Complex
… is obtained by shuttling electrons from the coenzyme ubiquinol (QH2) to coenzyme ubiquinone (Q) and the mobile cytochrome c. This well studied complex is ideal for examining molecular adaptation because it consists of ten different subunits, it functions as a dimer, and it includes at least …