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Showing 1 to 1 of 1 for “"codon engineering"”.
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A Novel, Codon-Based Approach to Preserve On-Tumor Activity and Reduce Off-Tumor Toxicity of Chimeric Antigen Receptor (CAR) T Cells
… <p> In our approach, we conducted rare codon engineering in Hu8F4-CAR in which select endogenous codons were strategically replaced with rare codons, or codons that are used at the lowest frequency in the human genome. In model organisms, the presence of rare codons has demonstrated the …