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Showing 1 to 20 of 29 for “"cocrystal"”.
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Insight into Nucleation Kinetics of Flufenamic Acid Cocrystal Formulation in Solution: Investigating the Role of Polymeric Excipients through Combined Experimental and Computational Approaches
… molecular interactions in flufenamic acid (FFA) cocrystal systems, with a particular focus on the role of polymeric excipients. The impact of selected polymers, polyvinyl pyrrolidone (PVP), polyvinylpyrrolidone-vinyl acetate copolymer (PVP-VA), polyethylene glycol (PEG), and soluplus (SOL), on …
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Novel Technology for Crystal Engineering of Pharmaceutical Solids
… in generating phase pure stable and metastable cocrystal phase. Based on the solubility of API and cocrystal former congruent (CBZ/SAC, SMT/SAC, SMZ/SAC) and incongruent (CAF/4HBA) cocrystal pairs were selected. For the first time generation of anhydrous phase of CAF: 4HBA cocrystal in 1:1 …
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A novel solvent-free high shear technology for the preparation of pharmaceutical cocrystals
… novel solvent-free method for the preparation of cocrystals. Cocrystals produced by HSMG were compared to those prepared by Hot Melt Extrusion (HME) to investigate the influence of variable parameters and conditions on the process of cocrystal conversion. The potential for the active control of …
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Effects of Polymers on Carbamazepine cocrystals phase transformation and release profiles
… the phase transformation and release profiles of cocrystals. Pharmaceutical cocrystals of Carbamazepine (CBZ) (namely 1:1 carbamazepine-nicotinamide (CBZ-NIC), 1:1 carbamazepine-saccharin (CBZ-SAC) and 1:1 carbamazepine-cinnamic acid (CBZ-CIN) cocrystals, were synthesized. A Quality by Design …
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Investigating the Dissolution and Permeation Properties of Flufenamic Acid Cocrystals
… and permeation properties of flufenamic acid cocrystals in the presence of polymers. This study was separated into four tasks: (1) Formation of pharmaceutical cocrystals: Two pharmaceutical cocrystals of poorly water soluble active pharmaceutical ingredient (API) flufenamic acid (FFA) were …
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Cocrystallisation involving the thioamide, amide and imide functional groups
… on the development and characterisation of novel cocrystals that incorporated the thioamide, amide and imide functional groups. A particular emphasis was placed on the characterisation of these cocrystals by single crystal X-ray diffraction methods. In Chapter One a summary of the intermolecular …
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Analytical method development for structural studies of pharmaceutical and related materials in solution and solid state. An investigation of the solid forms and mechanisms of formation of cocrystal systems using vibrational spectroscopic and X-ray diffraction techniques
… The work also covers the formation of novel cocrystal systems with pharmaceutically relevant materials. The existence of new cocrystals of salicylic acid-nicotinic acid, DLphenylalanine , 6-hydroxynicotinic acid, and 3,4-dihydroxybenzoic acid with oxalic acid have been identified from …
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Impurity-coformer cocrystals and/or complexes and their use in separations
… impurities from solution by selective impurity cocrystal formation where the cocrystal has a lower solubility than that of the impurity alone; (2) the use of coformers to form impurity-coformer complexes in solution followed by the crystallization of the desired compound; and (3) the selective …
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Solvatochromic pyrogallarenes and pyrogallarene crystals
… and hexamers have been isolated. One unique cocrystal, PgC[subscript 3]-(CH[subscript 3])[subscript 2]CO-0.5C[subscript 6]H[subscript 4]Cl[subscript 2]-nH[subscript 2]O, is shown here. This cocrystal of C-propyl pyrogallol[4]arene and the pharmaceutical gabapentin has the potential to alter …
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Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
… potential of crystal engineering directed cocrystallisation of active ingredients in modulating their physical attributes. The model compounds considered are isoniazid, caffeine, nifedipine, glyburide, chlorpropamide and riboflavin. Co-formers selected are based on the suitability of …
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Hydrogen bond mediated self-assembly: Solid state structures and synthesis of building blocks
… a trimesic acid$\bullet$pyrene$\bullet$ethanol cocrystal is described. The ""chicken-wire"" network found in trimesic acid was expanded through ethanol bridging of some of the hydrogen bonded carboxylic acid dimers. The expanded chicken wire networks of the structure do not interpenetrate. The …
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Integration Host Factor and Its Interaction With the H-Prime Site of Bacteriophage Lambda
… the structural data of the IHF-H$\sp\prime$ site cocrystal the specificity can be explained as a combination of direct and indirect readout of sequence information. Mutants that remove the glutamic acid 44 of the $\beta$-subunit restore wild-type levels of IHF binding to an H$\sp\prime$ site …
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An alternative path to physical form generation in pharmaceuticals
… CBZ. The sixth sample forms a hydronium chloride cocrystal with CBZ. Water from air is incorporated into the crystal structure of [CBZ(H)][Cl] which forms the CBZ hydronium chloride. Despite previous claims that non-aqueous conditions were necessary to protonate CBZ, work with aqueous acids …
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DNA Recognition by Helix-Loop-Helix Proteins
… of the homodimer. I also determined the cocrystal structure of a truncated b/HLH homodimer of the human transcription factor USF bound to DNA. As expected from the sequence conservation, this protein adopts the same three-dimensional structure as Max b/HLH. Circular dichroism …
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Supramolecular modification of selected antiretroviral drugs
… primary objective of this study was to carry out cocrystal screening and attempt cyclodextrin complexation with nevirapine, efavirenz, lamivudine and zidovudine, with a view to identifying and isolating new solid forms of these drugs. Any new forms were to be characterised by a variety of …
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Implementing process analytical technology (PAT) tools for the analysis and control of manufacturing processes during hot-melt extrusion
… release formulations. Extruded pharmaceutical cocrystals were manufactured by using carbamazepine (CBZ) as a model drug with saccharine (SCH) and trans-cinnamic acid (TCA) as coformers at a 1:1 molar ratio. In-line NIR was employed to monitor the cocrystallization process along the HME barrel …
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Interaction of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase with group I intron RNAs
… the tRNA in a Thermus thermophilus TyrRS/tRNATyr cocrystal structure.
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Phase behaviour and crystal nucleation in complex multicomponent system
… in this thesis would benefit future research in cocrystal nucleation from solution by informing experimental design and experimental configuration.
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Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology
… lability. Hydrochlorothiazide was prepared in cocrystal and coamorphous forms using hot melt extrusion in chapters 2-4, and meloxicam was prepared as a polymer amorphous solid dispersion in chapter 5, also using hot melt extrusion.<br/><i><br/>Thesis embargoed until 31 December 2026</i>.
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Understanding the crystal landscape of primary sulfinamides and predicting cocrystallization
… functional groups, to the synthesis of cocrystals. Chapter one is a brief introduction to the concepts and development of the field of crystal engineering over the past 30 years, including the definition and utilisation of the hydrogen bond in the synthesis of multicomponent materials, …
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