Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"cocaine addiction"”.
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The Role of Adult Neurogenesis in Cocaine Addiction
… drug-taking. I first examined effects of chronic cocaine self-administration and withdrawal on the different stages of neurogenesis. I found an early deficit in proliferation of neural progenitors, as well as a 4 week delayed increase in doublecortin-positive (DCX+) immature neurons which were …
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Role of BDNF-TrkB Signaling in Cocaine Addiction
Cocaine addiction results in neuroadaptations and drug-induced neuroplasticity that promote changes in protein expression and neuron morphology. Cocaine-induced increases in dopamine ultimately alter dopamine signaling in brain regions modulating reward and motivation, specifically the nucleus …
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ELUCIDATING AMPHETAMINE ACTIONS AT THE DOPAMINE TERMINAL: POTENTIAL FOR COCAINE ADDICTION TREATMENT
… with high clinical efficacy and limited addiction potential. The work contained in this dissertation is focused on elucidating amphetamine’s actions on dopamine neurotransmission that underlie its therapeutic actions as well as its abuse potential.
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The synthesis of 5-HT2 receptor designed multiple ligands to investigate the role of the 5-HT2AR and the 5-HT2CR in cocaine addiction
… that the 5-HT2AR and 5-HT2CR play a role in cocaine induced behavior modification through either stimulation or inhibition respectively. Recent research has revealed that dimerization and oligomerization of GPCRs including the 5-HTRs frequently occurs. In order to target these GPCR dimers and …
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Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation
Maternal cocaine addiction is a significant public health problem yet
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
<p>Cocaine sensitization is associated with cocaine-induced hyperexcitability of pyramidal projection neurons within the medial prefrontal cortex (mPFC). Such hyperexcitability presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area …
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Computational models of neuronal fear and addiction circuits
… spectrum. Subcircuits related to fear and addiction are considered at three levels, network, cellular and intracellular levels. In the area of fear learning, we developed biophysically realistic network models for two regions of the fear circuit. We first developed a computational network …
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Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations
Cocaine addiction is a chronic, relapsing disease affecting millions of Americans, and differences between individuals modulate the progression from cocaine use to addiction. Learned associations between cocaine and environmental stimuli develop in the subset of patients who become addicted, and …
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Exploring the Feasibility of an Anti-Idiotypic Cocaine Vaccine
Cocaine addiction is a major public health problem for which there are no proven psychotherapies or pharmacotherapies. Upon entry into the body, cocaine rapidly partitions to the brain. A possible means of negating the pharmacological activity of cocaine would be to interrupt the delivery of the …
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The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents
… there are no approved medications for treating cocaine addiction, and cocaine addicts are highly prone to relapse. Cocaine cravings or seeking is difficult to control because of contextual cues and adequate treatment is not available. Previous studies found that group I metabotropic glutamate …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… phosphorylation in vivo produced by chronic cocaine and heroin self-administration, changes in mesolimbic protein phosphorylation compared to individual differences in the propensity for escalating cocaine self-adminstration, and, ultimately, dopamine receptor-mediated regulation of relapse …
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The synthesis of WAY-derivatives to find linker location and a new linker to attach a fluorescence tag for homo- or hetero-dimer of 5-HT receptor ligands
… to correlate with depression, obesity and drug addiction. The serotonin receptor has been studied as a possible target for cocaine addiction therapy. Previously, 5-HT 2A receptor antagonist, M100907 and 5-HT 2C receptor agonist, WAY 163909 have been studied as molecules to control behaviors …
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Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
… to search for potential therapeutic agents for cocaine addiction, a novel class of compounds was synthesized and evaluated for in vitro dopamine and serotonin transporter affinities. These unique 3ƒÀ-aryl-3ƒ¿-arylmethoxytropane analogues incorporated the structure of dopamine selective …
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Patterns of Cocaine Consumption: A Sub-Analysis of the Drugnet Survey
The myths and misconceptions that surround cocaine use lead to the over-estimation of the prevalence of cocaine addiction in society. Health education curricula and drug policy do not differentiate between cocaine use and abuse. This study describes the cocaine consumption patterns in a …
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Treatment Effects Related to EEG-Biofeedback for Crack Cocaine Dependency: Changes in Personality and Attentional Variables
… EEG biofeedback has addressed alcohol addiction. Cocaine is now considered to be the most common drug problem of patients entering treatment for drug abuse. To date, only one controlled study has been published that researched alpha-theta neurofeedback in the treatment of "crack" …
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Cocaine Dependence: The Role of Serotonin Genes In
… studies have shown that behavioral responses to cocaine-related cues are altered by serotonergic medications. The effects of pharmacological agents on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists promote the …
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Modeling of flexible drug-like molecules : qsar of GBR 12909 analog dat/sert selectivity
… on the dopamine transporter (DAT) to treat cocaine addiction. Undesirable binding to the serotonin transporter (SERT) can vary greatly depending on the specific substituents on the molecule. This study uses Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity …
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Behavioural and cellular basis of the vulnerability to develop compulsive heroin seeking habits
Addiction is a chronic relapsing disorder for which there is no effective treatment. This may reflect our lack of understanding of the psychological and neural mechanisms that support the transition, in vulnerable individuals, from recreational drug use to compulsive drug seeking habits. Over the …
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Parsing Distinct Aspects of the Addiction Process Using Cocaine Self-Administration, Behavioral Economics, Neuropharmacology and Neurochemistry
… understanding of the neurobiological basis of cocaine addiction, scientists have begun to investigate the neural adaptations occurring in association with changes in behavior observed in animal models of addiction. Exactly how these behavioral changes relate to the addiction process, however, …
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