Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"cocaine abuse"”.
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Understanding comorbid ADHD and cocaine abuse: consequences of adolescent medication in an animal model
… with substance use disorders, particularly cocaine. Preclinical studies using the well-validated Spontaneously Hypertensive Rat (SHR) model of ADHD suggest that adolescent treatment with the stimulant methylphenidate increases cocaine abuse risk in adulthood, highlighting the need to …
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EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD
… disturbance, cognitive disruptions and drug abuse. These studies used Old World macaques, rhesus monkeys, because of their close phylogeny to humans, their similar sleep-wake patterns and their cognitive abilities.
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Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration
… currently no FDA-approved drug treatments for cocaine abuse. The use of female subjects and a better understanding of the influence of hormones and cognitive function may provide valuable information to aid in pharmacotherapy development. The present studies utilized female monkeys housed in …
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Potential involvement of gap junctions in pathology of addiction
Cocaine abuse represents a huge social problem for the widespread in the world and for the many health risks associated. Moreover, a significative percentage of cocaine users develop an addiction with loss of control on drug intake. Several molecular modifications occurs with cocaine use, some of …
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Heritable variation in reward sensitivity and impulsive cction and choice in a genetically diverse inbred mouse panel
… to characterize CC and DO mice for multiple, cocaine abuse related traits.</p>
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2d quantitative structure activity relationship modeling of methylphenidate analogues using algorithm and partial least square regression
… methylphenidate analogues for the treatment of cocaine abuse. The GA-PLS program was tested on the benchmark Selwood dataset of antifilarial antimycin analogues and identified several molecular descriptors in common with other 2D QSAR models.
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FACTORS THAT AFFECT SOCIAL HIERARCHY AND THE INFLUENCE OF SOCIAL RANK AND MENSTRUAL CYCLE ON COCAINE SELF-ADMINISTRATION IN FEMALE CYNOMOLGUS MONKEYS
… may have a greater biological vulnerability to cocaine addiction than males. Studying behavioral, neurochemical, neurobiological or physiological trait and state variables may provide some insight into individual difference leading to high risk for drug abuse. The research described in this …
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Analysis of molecular conformations using relative planes
… a drug potentially useful in the treatment of cocaine abuse. The present work suggests that the Planes program could be potentially useful in the description of the relative orientation of pharmacophore features if the molecular conformations could first be classified by their orientation …
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Synthesis and structure-activity relationship of a series of sigma receptor ligands
… might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual structure-activity relationships, a series of N-phenylpropyl- N'-benzylpiperazine and N-phenylpropyl-4-benzylpiperidine analogs systematically substituted …
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Cocaine Induces Apoptosis in Coronary Artery Endothelial Cells: Cellular and Molecular Mechanisms
<p>Cocaine abuse has been associated with numerous cardiovascular consequences, such as depressed myocardial contractility, elevated blood pressure, coronary artery vasoconstriction, and myocardial ischemia and infarction. The multifactorial effects of cocaine often contribute to its …
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Design, synthesis, and biological evaluation of sigma receptors (σRS) ligands as potential pharmacotherapy for cancer and drug addiction
… anxiety, Alzheimer’s disease, epilepsy and drug abuse. The sigma-1 receptor has been demonstrated to be involved in acute and chronic effects of cocaine and methamphetamine toxicities. However, the role of sigma-2 receptors is less clear due to the lack of availability of detailed protein …
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Metabolism And Pharmacokinetics In The Development Of New Therapeutics For Cocaine And Opioid Abuse
Cocaine and opioid abuse are a major public health concern and the cause of significant morbidity and mortality worldwide. The development of effective medication for cocaine and opioid abuse is necessary to reduce the impact of this issue upon the individual and society. The pharmacologic …
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Prenatal Cocaine Exposure and Cardiac Programming
… of ischemia heart disease in later adult life. Cocaine abuse during pregnancy has been shown to cause abnormities in the heart during fetal and postnatal development, but mechanisms underlying the detrimental effects of cocaine on the developing heart are not fully understood. The central …
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Etiological Characterization of Emergency Department Acute Poisoning
… most common cause of poisoning at 35.4% (n=230), cocaine overdose at 31.7% (n=206), heroin and cocaine overdose at 4.3% (n=28), multiple drug poisoning at 5.5% (n=36), and antidepressant/antipsychotic poisoning at 6% (n=39). A significant correlation between heroin poisonings and asthma (F=20.29, …
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Investigations of the neurobiological and behavioural actions of cocaine
… once considered a benign recreational stimulant, cocaine is now recognized to possess substantial abuse potential with considerable medical and social consequences. Accordingly, these experiments examined the behavioural and neurobiological effects of cocaine in the rat. The behavioural and …
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Ligand-based drug design : I. conformational studies of GBR 12909 analogs as cocaine antagonists; II. 3d-QSAR studies of salvinorin a analogs as kappa opioid agonists
… have potential usefulness in the treatment of cocaine abuse. As a first step in the 3D-QSAR modeling of the dopamine transporter (DAT)/serotonin transporter (SERT) selectivity of these compounds, conformational analysis of a piperazine and related piperidine analog of GBR12909 is performed. …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… reward-pathway, which is ‘hijacked’ by drugs of abuse. We have previously shown for accumbal medium spiny neurons (MSNs) that α2-subunit containing GABAA receptors (α2-GABAARs), mediate phasic inhibition and that their genetic inactivation (α2-/-) abolishes behavioural sensitisation to cocaine. …
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The effect of voluntary binge caffeine and ethanol coexposure on neurobehavioral sensitivity to cocaine in male C57BL/6J mice
… alcohol use alone have been linked to polydrug abuse. It is therefore of interest whether combined caffeine and alcohol consumption may pose an additive risk for substance abuse. Given that both compounds can positively influence dopamine signaling in mesolimbocortical reward circuitry via …
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The effect of voluntary binge caffeine and ethanol co-exposure on neurobehavioral sensitivity to cocaine in male C57BL/6J mice
… alcohol use alone have been linked to polydrug abuse. It is therefore of interest whether combined caffeine and alcohol consumption may pose an additive risk for substance abuse. Given that both compounds can positively influence dopamine signaling in mesolimbocortical reward circuitry via …