Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"cocaethylene"”.
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Microvascular endothelial response to cocaethylene exposure: morphological and molecular observations
Cocaethylene (CE) is an active metabolite of cocaine and ethanol and is a toxicant of physiological relevance due to the high rate of cocaine and ethanol co-exposure (~80%) in cocaine abusers. It has prolonged action and increased potency on known physiological targets relative to the effect of …
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The interaction of psychomotor stimulants and sedative hypnotics in the conditioned taste aversion paradigm
… interaction was asymmetrical and therefore not cocaethylene mediated. Experiment 2 examined the potential for nicotine and ethanol to interact pharmacologically in the pretreatment CTA procedure. These results demonstrated that nicotine and ethanol interacted pharmacologically in an asymmetrical …
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Pharmacokinectic and pharmacodynamic aspects of cocaine and its interaction with ethanol
… on cocaine disposition. Further, cocaine and cocaethylene (CE) were compared using pharmacokinetic-pharmacodynamic (PK-PD) models. Lastly, PK-PD models after cocaine and a combination of cocaine and ethanol dose were developed. Cocaine was administered by iv with or without ethanol in rats. CE …
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New Developments in Analytical Toxicology for the Investigation of Drug Facilitated Crime
… whether there is a correlation between EtG and cocaethylene (a metabolite of cocaine only produced in the presence of alcohol) in cocaine users. Results f this study suggest that there is no positive correlation between the two compounds.<br/><br/>The research presented in this thesis aims to …
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The detection of drugs of abuse in biological matrices using enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry
… of the drug group specific GC-MS method. Cocaethylene and EME were detected in some samples by LC-MS-MS method for opiates and cocaine and its metabolites compared to the GC-MS method; there may be some cases where the GC-MS method would detect the analytes where the LC-MS-MS method would …
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The Distribution of opiates, cocaine and their metabolites in skeletal muscle tissue and vitreous humour as an aid to post-mortem toxicological interpretation.
… and its metabolites, benzoylecgonine (BZE) and cocaethylene (COET), to be uniformly distributed throughout the thigh muscle (n = 7). Concentrations of cocaine in muscle were markedly higher than in blood and correlated well with the blood. The stability of cocaine in muscle tissue was found to …
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Determination of biomarkers for toxicity and antiretroviral adherence in hair in South African patients
… methamphetamine, cocaine, benzoylecgonine, cocaethylene and methaqualone. The final method developed was for the quantification of efavirenz in 0.2 mg samples of hair. This method was validated over the calibration range 0.625 - 40 ng/mg. The validated methods were applied to 257 samples of …